Abstract: Systems for controlled closure of body lumens may utilize a single access port which is attached to a vessel wall and allows for controlled closure and/or insertion of small to large sized instruments and catheters. The vascular access device generally includes a first frame and a second frame having an access port secured between the respective frames, e.g. via adhesive, welding, etc. Each respective frame may be configured to include a support member which may be shaped in a variety of configurations so long as an access opening is defined by the support member. A number of retaining members may extend radially from its respective support member and each retaining member may be configured so as to compress or “sandwich” the vessel tissue which surrounds the tissue opening between the retaining members on the inner and outer surfaces of tissue to securely position the device along the vessel wall.