Patents Assigned to Artesian Therapeutics, Inc.
  • Cardiotonic Compounds With Inhibitory Activity Against Beta-Adrenergic Receptors And Phosphodiesterase
    Publication number: 20080255134
    Abstract: The present invention provides compounds of formula (I) possessing inhibitory activity against ? adrenergic receptors and phosphodiesterase (PDE), including type 3 phosphodiesterase (PDE-3). The present invention further provides pharmaceutical compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for regulating calcium homeostasis, for treating a disease, disorder or condition in which disregulation of calcium homeostasis is implicated and for treating cardiovascular disease, stroke, epilepsy, an ophthalmic disorder or migraine.
    Type: Application
    Filed: November 8, 2005
    Publication date: October 16, 2008
    Applicant: Artesian Therapeutics, Inc.
    Inventors: Malcolm George Taylor, Burkhard Klenke, Peter D. Suzdak, Reza Mazhari
  • Compounds With Mixed Pde-Inhibitory and Beta-Adrenergic Antagonist or Partial Agonist Activity For Treatment of Heart Failure
    Publication number: 20080090827
    Abstract: This invention provides compounds that possess inhibitory activity against ?-adrenergic receptors and phosphodiesterase PDE, including phosphodiesterase 3 (PDE3). This invention further provides pharmaceutical compositions comprising such compounds; methods of using such compounds for treating cardiovascular disease, stroke, epilepsy, ophthalmic disorder or migraine; and methods of preparing pharmaceutical compositions and compounds that possess inhibitory activity against ?-adrenergic receptors and PDE.
    Type: Application
    Filed: November 8, 2005
    Publication date: April 17, 2008
    Applicant: Artesian Therapeutics, Inc.
    Inventors: Malcolm Taylor, Burkhard Klenke, Peter Suzdak, Reza Mazhari
  • Compounds having simultaneous ability to block L-type calcium channels and to inhibit phosphodiesterase type 3 activity
    Publication number: 20070066619
    Abstract: The present invention provides compounds that possess inhibitory activity against PDE-3 and L-type calcium channels. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating cardiovascular disease, stroke, epilepsy, ophthalmic disorder or migraine.
    Type: Application
    Filed: August 4, 2006
    Publication date: March 22, 2007
    Applicant: Artesian Therapeutics, Inc.
    Inventors: Gregory Hamilton, Harry Leighton, Jeff Bechard, Beth Allison, John Gibson
  • Compounds having simultaneous ability to block L-type calcium channels and to inhibit phosphodiesterase type 3 activity
    Patent number: 7098211
    Abstract: The present invention provides compounds that possess inhibitory activity against PDE-3 and L-type calcium channels. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating cardiovascular disease, stroke, epilepsy, ophthalmic disorder or migraine.
    Type: Grant
    Filed: October 7, 2003
    Date of Patent: August 29, 2006
    Assignee: Artesian Therapeutics, Inc.
    Inventors: Gregory S. Hamilton, Harry Jefferson Leighton