Patents Assigned to Artesian Therapeutics, Inc.
  • METHODS OF MAKING COMPOUNDS HAVING A BETA-ADRENERGIC INHIBITOR AND A LINKER AND METHODS OF MAKING COMPOUNDS HAVING A BETA-ADRENERGIC INHIBITOR, A LINKER AND A PHOSPHODIESTERASE INHIBITOR
    Publication number: 20080262226
    Abstract: A method is provided for making compounds comprising a beta-adrenergic inhibiting moiety and a linking moiety, the method comprising: a) reacting a compound of formula (A): (R1—(CH—O—CH2)) with at least one of NH3, NH4, NH4ClNH3 and R12?NH2 thereby forming a compound of formula (B): (R1—CH(OH)—CH2—NHR12?); and b) reacting a compound of formula (B) with a compound of formula (C): (R3?O), thereby forming a compound of formula (D): (R1—COH—CH2—N(R3)(R12?)), wherein R1 comprises the beta-adrenergic inhibiting moiety or comprises the beta-adrenergic inhibiting moiety when bonded to —COH—CH2—N(R12?)— of formula (D); R3 comprises the linking moiety and is bonded to the =0 of formula (C) via a carbon atom; and R12? is selected from hydrogen and a protecting group.
    Type: Application
    Filed: November 7, 2007
    Publication date: October 23, 2008
    Applicant: ARTESIAN THERAPEUTICS, INC.
    Inventor: Gang Chen
  • Cardiotonic Compounds With Inhibitory Activity Against Beta-Adrenergic Receptors And Phosphodiesterase
    Publication number: 20080255134
    Abstract: The present invention provides compounds of formula (I) possessing inhibitory activity against ? adrenergic receptors and phosphodiesterase (PDE), including type 3 phosphodiesterase (PDE-3). The present invention further provides pharmaceutical compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for regulating calcium homeostasis, for treating a disease, disorder or condition in which disregulation of calcium homeostasis is implicated and for treating cardiovascular disease, stroke, epilepsy, an ophthalmic disorder or migraine.
    Type: Application
    Filed: November 8, 2005
    Publication date: October 16, 2008
    Applicant: Artesian Therapeutics, Inc.
    Inventors: Malcolm George Taylor, Burkhard Klenke, Peter D. Suzdak, Reza Mazhari
  • Compounds With Mixed Pde-Inhibitory and Beta-Adrenergic Antagonist or Partial Agonist Activity For Treatment of Heart Failure
    Publication number: 20080090827
    Abstract: This invention provides compounds that possess inhibitory activity against ?-adrenergic receptors and phosphodiesterase PDE, including phosphodiesterase 3 (PDE3). This invention further provides pharmaceutical compositions comprising such compounds; methods of using such compounds for treating cardiovascular disease, stroke, epilepsy, ophthalmic disorder or migraine; and methods of preparing pharmaceutical compositions and compounds that possess inhibitory activity against ?-adrenergic receptors and PDE.
    Type: Application
    Filed: November 8, 2005
    Publication date: April 17, 2008
    Applicant: Artesian Therapeutics, Inc.
    Inventors: Malcolm Taylor, Burkhard Klenke, Peter Suzdak, Reza Mazhari
  • Compounds having simultaneous ability to block L-type calcium channels and to inhibit phosphodiesterase type 3 activity
    Publication number: 20070066619
    Abstract: The present invention provides compounds that possess inhibitory activity against PDE-3 and L-type calcium channels. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating cardiovascular disease, stroke, epilepsy, ophthalmic disorder or migraine.
    Type: Application
    Filed: August 4, 2006
    Publication date: March 22, 2007
    Applicant: Artesian Therapeutics, Inc.
    Inventors: Gregory Hamilton, Harry Leighton, Jeff Bechard, Beth Allison, John Gibson
  • Compounds having simultaneous ability to block L-type calcium channels and to inhibit phosphodiesterase type 3 activity
    Patent number: 7098211
    Abstract: The present invention provides compounds that possess inhibitory activity against PDE-3 and L-type calcium channels. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating cardiovascular disease, stroke, epilepsy, ophthalmic disorder or migraine.
    Type: Grant
    Filed: October 7, 2003
    Date of Patent: August 29, 2006
    Assignee: Artesian Therapeutics, Inc.
    Inventors: Gregory S. Hamilton, Harry Jefferson Leighton
  • Compounds having simultaneous ability to block L-type calcium channels and to inhibit phosphodiesterase type 3 activity
    Publication number: 20040242648
    Abstract: The present invention provides compounds that possess inhibitory activity against PDE-3 and L-type calcium channels. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating cardiovascular disease, stroke, epilepsy, ophthalmic disorder or migraine.
    Type: Application
    Filed: October 7, 2003
    Publication date: December 2, 2004
    Applicant: ARTESIAN THERAPEUTICS, INC.
    Inventors: Gregory S. Hamilton, Harry Jefferson Leighton