Abstract: The present invention provides an application of an SARM1 enzyme activity inhibitor in the treatment of neurodegenerative diseases or neurological diseases or conditions. The present invention particularly provides a compound of formula I as an SARM1 enzyme activity inhibitor and a pharmaceutical composition thereof.
Type:
Application
Filed:
August 25, 2022
Publication date:
November 7, 2024
Applicant:
ARTIVILA BIOPHARMA
Inventors:
Deqiang NIU, Zhendong ZHU, Ming FAN, Xuke LI
Abstract: Provided in the present disclosure is the use of an SARM1 enzyme activity inhibitor in the treatment of neurodegenerative diseases or neurological diseases or conditions, and in particular, provided in the present invention are a compound represented by formula (a) as an SARM1 enzyme activity inhibitor, and a pharmaceutical composition thereof.
Type:
Application
Filed:
November 9, 2021
Publication date:
December 28, 2023
Applicant:
ARTIVILA BIOPHARMA
Inventors:
Deqiang NIU, Zhendong ZHU, Yongjuan ZHAO, Wanhua LI
Abstract: Useful chiral specific boron-containing compounds, such as boronate, boronate esters, boranamines, borane diamines, boranamine thioesters, and boronic mono/di-thioesters, have been prepared. These compounds and compositions containing them are useful as anti-cancer or anti-amyloidosis agents.