Patents Assigned to ARUNA BIO, INC.
  • NEURAL CELL EXTRACELLULAR VESICLES
    Publication number: 20250019650
    Abstract: Disclosed herein are neural extracellular vesicles (EVs) and methods of using these EVs in the treatment of spinal cord injury, stroke, and traumatic brain injury and neurodegenerative diseases.
    Type: Application
    Filed: April 29, 2024
    Publication date: January 16, 2025
    Applicants: Aruna Bio, Inc., University of Georgia Research Foundation, Inc.
    Inventors: Steven L. Stice, Robin Lynn Webb, Tracey A. Stice
  • Neural cell extracellular vesicles
    Patent number: 12139723
    Abstract: Disclosed herein are neural extracellular vesicles (EVs) and methods of using these EVs in the treatment of spinal cord injury, stroke, and traumatic brain injury and neurodegenerative disease.
    Type: Grant
    Filed: April 23, 2021
    Date of Patent: November 12, 2024
    Assignees: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC., ARUNA BIO, INC.
    Inventors: Steven L. Stice, Robin Lynn Webb, Tracey A. Stice
  • Neural cell extracellular vesicles
    Patent number: 11993787
    Abstract: Disclosed herein are neural extracellular vesicles (EVs) and methods of using these EVs in the treatment of spinal cord injury, stroke, and traumatic brain injury and neurodegenerative diseases.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: May 28, 2024
    Assignees: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC., Aruna Bio, Inc.
    Inventors: Steven L. Stice, Robin Lynn Webb, Tracy A. Stice
  • BINDING AGENTS AND USES THEREOF FOR CENTRAL NERVOUS SYSTEM DELIVERY
    Publication number: 20230173094
    Abstract: Disclosed herein are binding agents, conjugates, and extracellular vesicles that enhance penetration of the blood brain barrier. Uses thereof for delivery of agents, e.g., therapeutic agents, to the central nervous system are also provided.
    Type: Application
    Filed: April 27, 2021
    Publication date: June 8, 2023
    Applicant: Aruna Bio, Inc.
    Inventors: Steven L. Stice, Raymond Swetenburg
  • EXTRACELLULAR VESICLES AND USES THEREOF FOR ANTIBODY DELIVERY
    Publication number: 20220409738
    Abstract: Disclosed herein are methods of delivering a polypeptide, e.g., an antibody or antigen binding portion thereof, to the central nervous system of a subject, by administering to the subject the polypeptide (e.g., antibody or antigen-binding portion thereof) conjugated to the surface of an extracellular vesicle (EV) derived from a neural cell, e.g., a neural progenitor cell or a neural stem cell. Conjugates comprising neural EVs coupled to a polypeptide, such as an antibody or antigen binding portion thereof, and methods of use thereof, are also provided. Also disclosed herein are methods of delivering a polypeptide, e.g., an antibody or antigen binding portion thereof, by administering to the subject the polypeptide (e.g., antibody or antigen-binding portion thereof) loaded within the lumen of an extracellular vesicle (EV) derived from neural cells.
    Type: Application
    Filed: May 3, 2022
    Publication date: December 29, 2022
    Applicant: Aruna Bio, Inc.
    Inventors: Steven L. Stice, Raymond Swetenburg, Rhianna K. Carty
  • Neural cell extracellular vesicles
    Patent number: 11111475
    Abstract: Disclosed herein are neural extracellular vesicles (EVs) and methods of using these EVs in the treatment of spinal cord injury, stroke, and traumatic brain injury and neurodegenerative diseases.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: September 7, 2021
    Assignees: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC., ARUNA BIO, INC.
    Inventors: Steven L. Stice, Robin Lynn Webb, Tracy A. Stice