Abstract: Dissolvable unit dose film constructs are made by providing a muco-adhesive composition including a muco-adhesive polymer matrix in which the muco-adhesive polymer matrix has a water-soluble polymer, water-dispersible polymer, water-swellable polymer, or combinations thereof and a liquid carrier. The method further includes drying the muco-adhesive composition to remove at least a portion of the liquid carrier, forming a muco-adhesive film substrate, forming a composition for an active layer, the composition including a polymer matrix in which the polymer matrix for the active layer composition includes a water-soluble polymer, water-dispersible polymer, water-swellable polymer, or combinations thereof, an active ingredient and a liquid carrier.

Abstract: Disclosed herein are methods of administering relatively high doses of dexmedetomidine or a pharmaceutically acceptable salt thereof to a human subject, without also inducing significant sedation. The disclosed methods are particularly suitable for the treatment of agitation, especially when associated with neurodegenerative and/or neuropsychiatric diseases such as schizophrenia, bipolar illness such as bipolar disorder or mania, dementia, depression, or delirium.

Abstract: A press device comprising a press ring for pressing together tubular workpieces in between, and at least a first and a second pivotable jaw is described. The first jaw comprises a first engagement section and the second jaw comprises a second engagement section. The press ring comprises a first and a second receiving section for receiving the first and the second engagement section of the press jaws, respectively. A first and a second surface of the first and the second receiving section, respectively, contact the first and the second engagement section, respectively. Each comprise a planar surface. The first and the second contact surface oppose each other for applying a press force F. The first contact surface and the second contact surface each comprise at least one convex surface.

Abstract: A pressing tool for plastically deforming a tubular workpiece, and particularly a fitting is described. The pressing tool comprises a pressing jaw receptacle for coupling a pressing jaw assembly to the pressing tool. The pressing tool further comprises a drive which is adapted to drive a coupled pressing jaw assembly in order to apply force to a workpiece, and a sensor system which is adapted to identify a pressing jaw assembly and to provide corresponding sensor data, wherein a control is adapted to control the drive based on the sensor data. Also described are related methods, pressing jaw assemblies, and workpieces.

Abstract: Disclosed herein is a self-supporting, dissolvable, film containing dexmedetomidine or a pharmaceutically acceptable salt thereof. The film is administered orally to treat various conditions, particularly agitation, by transmucosal delivery of the active agent.

Abstract: Disclosed herein is a self-supporting, dissolvable, film containing dexmedetomidine or a pharmaceutically acceptable salt thereof. The film is administered orally to treat various conditions, particularly agitation, by transmucosal delivery of the active agent.

Abstract: Disclosed herein is a self-supporting, dissolvable, film containing dexmedetomidine or a pharmaceutically acceptable salt thereof. The film is administered orally to treat various conditions, particularly agitation, by transmucosal delivery of the active agent.

Abstract: Disclosed herein is a self-supporting, dissolvable, film containing dexmedetomidine or a pharmaceutically acceptable salt thereof. The film is administered orally to treat various conditions, particularly agitation, by transmucosal delivery of the active agent.

Abstract: A press device comprising a press ring for pressing together tubular workpieces in between, and at least a first and a second pivotable jaw is described. The jaws comprise engagement sections. The press ring comprises receiving sections for receiving the engagement sections of the press jaws. A first and a second surface of the receiving sections, contact the engagement sections. Each of the first and second surface comprises a planar surface. The engagement sections comprise contact surfaces. The contact surfaces oppose each other for applying a press force F. The contact surfaces each comprise at least one convex surface, such that a radius of curvature r of the first and the second contact surface is larger than half a width Wx, Wz, measured perpendicular to an axis of curvature, of the respective first and second contact surface.

Abstract: A pressing machine is described for plastically deforming a tubular workpiece, in particular a fitting. The pressing machine has a motor, and pressing jaws which are driven by the motor and can apply a force to the workpiece during operation. The pressing machine also has a power transmission unit coupled to the motor and the pressing jaws for transmitting power from the motor to the pressing jaws. The pressing machine also has at least one sensor unit for measuring at least one pressing parameter P and a controller which receives the currently measured value of the pressing parameter P from the sensor unit and determines therewith the pitch or slope of a press parameter curve K of the press parameter P. The controller terminates a pressing operation before reaching a maximum possible pressing force Pmax when the pitch or slope of the press parameter curve K of the press parameter P satisfies a shutdown criterion. Also described is a corresponding method for operating a pressing machine.

Abstract: Systems, methods, and devices for measuring force applied to a machine, where an exercise machine comprises a frame; a motor assembly; a mounting plate, wherein the mounting plate is attached to the motor assembly; a force transducer. The force transducer is attached to the mounting plate and the frame and is the only point of contact between the frame and the motor assembly. The force transducer is configured to measure force applied to the motor assembly.

Abstract: A pressing tool, particularly a pipe pressing tool, for plastically deforming a tubular workpiece, particularly a fitting, is described. The pressing tool includes pressing jaws and a motor which is adapted to drive the pressing jaws in order to apply a force to the workpiece. Further, a method of operating such a pressing tool, and pressing jaws as well as a tubular workpiece are described.

Abstract: A pressing tool is described for plastically deforming a workpiece. The pressing tool comprises a piston pump driven by a motor that rotates in operating rotation direction RA and a pressure release valve and a coupling arrangement, which mechanically couples the motor to the pressure relief valve, so that the motor opens the pressure relief valve when operated in a loosening rotation direction RL opposite to the operating rotation direction RA. Also described is a corresponding method of operating a pressing tool.

Abstract: A press ring (1) for pressing tubular workpieces (35), comprising: at least two movable press jaws (3); and at least one connecting press jaw (5) connecting the movable press jaws (3); wherein the movable press jaws (3) are each hinged at their proximal ends to the connecting press jaw (5) by means of respective bolts (9), so that the distal ends (7) of the movable press jaws (3) can be rotated towards and away from each other to close respectively open the press ring (1) to receive a workpiece (35) therein, and characterized in that the respective bolts (9) are arranged in elongated holes (11), allowing a translational displacement of the bolts (9) in the elongated holes (11) upon rotating the movable press jaws (3).

Abstract: A mathematically accurate cybersecurity risk analysis platform which is able to quantify the effects of cybersecurity risk in several inter-related dimensions, and accomplish this within established regulatory and audit-control frameworks, providing risk analyses which are not simply the function of professional judgement or expert opinion. The specific dimensions are between Threats, Risks, Vulnerabilities and Capabilities.

Abstract: Disclosed herein is a self-supporting, dissolvable, film containing dexmedetomidine or a pharmaceutically acceptable salt thereof. The film is administered orally to treat various conditions, particularly agitation, by transmucosal delivery of the active agent.

Abstract: A coupling is described for connecting an interchangeable tool head to a machine part of a pressing device. The machine part features a receptacle region (A) for accommodating a shaft section of an interchangeable tool head, which can be axially displaced in the receptacle region (A), and the shaft section comprises an end face (S) and at least two engaging elements. The at least two holding elements are arranged in the receptacle region (A) and a guide groove is respectively formed between two adjacent holding elements. Also described are tools such as pressing devices utilizing the couplings and related methods.

Abstract: A self-adjusting floating environment (SAFE) system is described. The SAFE system can include a construction platform which floats on a buffer medium and a vertical motion isolation system. In an earthquake, a construction platform floating on a buffer medium may experience greatly reduced shear forces. In a flood, a construction platform floating on a buffer medium can be configured to rise as water levels rise to limit flood damage. The vertical motion isolation system can reduce the vertical motion of the construction platform induced from vertical ground movements during an earthquake.

Abstract: Systems, methods, and devices for measuring force applied to a machine, where an exercise machine comprises a frame; a motor assembly; a mounting plate, wherein the mounting plate is attached to the motor assembly; a force transducer. The force transducer is attached to the mounting plate and the frame and is the only point of contact between the frame and the motor assembly. The force transducer is configured to measure force applied to the motor assembly.

Abstract: A self-adjusting floating environment (SAFE) system is described. The SAFE system can include a construction platform which floats on a buffer medium and a vertical motion isolation system. In an earthquake, a construction platform floating on a buffer medium may experience greatly reduced shear forces. In a flood, a construction platform floating on a buffer medium can be configured to rise as water levels rise to limit flood damage. The vertical motion isolation system can reduce the vertical motion of the construction platform induced from vertical ground movements during an earthquake.