Abstract: The invention provides computational methods for engineering, selecting, and/or identifying proteins with a desired activity. Further provided are automated computational design and screening methods to engineer proteins with desired functional activities including, but not limited to ligand binding, catalytic activity, substrate specificity, regioselectivity and/or stereoselectivity.
Type:
Grant
Filed:
June 14, 2018
Date of Patent:
July 19, 2022
Assignee:
Arzeda Corporation
Inventors:
Alexandre Zanghellini, Yih-En Andrew Ban, Eric Anthony Althoff, Daniela Grabs, Mihai Luchian Azoitei
Abstract: The invention provides processes for the conversion of pyruvate obtained from sugars or other carbon sources, to valuable C5 materials such as levulinic acid, levulinate esters, valerolactone, and derivatives thereof.