Abstract: In a fluid dispenser for germ-free fluid, in particular eye-drops, the delivery passage from a supply container contains an oligodynamically germicidally active substance that is soluble in the fluid. Said device comprises a metering pump operating without air pressure compensation and having an inlet valve for closing the inlet opening from said container and said fluid-soluble oligodynamically germicidally active substance is situated in the region of said inlet valve or of the inlet thereto and/or the outlet therefrom.

Abstract: The present invention pertains to cyclosporin-containing liquid preparations for oral or parenteral administration, as well as to a process for preparing same. Besides the active ingredient cyclosporin, the preparations contain a polyoxyethylene glycerol fatty acid monoester and a monohydric and/or polyhydric alcohol(s). The preparations are stable and well tolerated, and they have higher bioavailability than the preparations known currently.

Abstract: Galanthamine and the pharmaceutically suitable acid addition salts thereof can be used for the treatment of alcoholism; these compounds are released from adequate pharmaceutic formulations which are administered, e.g., orally, transdermally, or otherwise parenterally, in a continuous and controlled manner.

Abstract: In a process for the microencapsulation of water-soluble active ingredients according to the principle of phase separation, which comprises the steps(a) Preparation of a solution of a biocompatible polymer in an organic solvent;(b) Addition of an aqueous solution of one or more active ingredients or dispersion of one or more solid active ingredients in the solution from stage (a);(c) Addition of a coacervation agent to the emulsion or dispersion from stage (b);(d) Introduction of the mixture from stage (c) into an excess of a hardening agent;(e) Collection and washing of the microcapsules,natural or synthetic esters of saturated C.sub.4 to C.sub.18 carboxylic acids and polyhydric alcohols are used as hardening agents.

Abstract: Certain new phenone derivatives of the formula (I) ##STR1## in which R.sup.1 =CH.sub.3,R.sup.2 =H, Cl, Br, I, methyl, hydroxy, methoxy, propoxy, propoxy or ethoxy;R.sup.3 =H or .beta.-D-glykosyl;R.sup.4 =H, Cl, Br, I, methyl, hydroxy, methoxy, propoxy, iso-propoxy or ethoxy;R.sup.5 =H or hydroxy,and the pharmaceutically acceptable salts, ethers and esters thereof, with the exception of the compounds 4-hydroxyacetophenone, 4-hydroxy-3-methoxy-acetophenone, 4-glucopyranosyloxy-acetophenone, 4-glucopyranosyloxy-3-methoxyacetophenone, 4-galactopyranosyloxy-3-methoxy-acetophenone, 4-glucopyranosyloxy-3,5-dimethoxy-acetophenone and galactopyranosyloxy-3,5-dimethoxy-acetophenone and a method for manufacturing them and pharmaceutical preparations containing them. The invention also concerns pharmaceutical preparations containing at least one compound of the formula (II) ##STR2## in which R.sup.1 denotes H, OH, alkoxy or C.sub.1-8 alkyl;R.sup.2 denotes H or C.sub.1-4 alkoxy;R.sup.3 denotes OH or a .beta.

Abstract: A process for producing pellets which are markedly spherical and have a particle size in the range from 0.1 to 4 mm and an apparent density above 0.5 g/cm.sup.3, and which are composed of 90-100% by weight of an ephedrine derivative and 0-10% by weight of a pharmaceutical aid, entails suspending ephedrine derivative powder with an average particle size of from 0.5 to 50 .mu.m at 0.degree.-90.degree. C. with stirring in a water-immiscible non solvent with a boiling point in the range from 60.degree. to 160.degree. C., adding 5-60% by weight, based on the ephedrine derivative, of an agglomerating liquid while continuing stirring, and, if there has been previous heating, cooling to from -5 to 25.degree. C. at 5-40K per hour, with the stirring speed being adjusted after the agglomeration of the powder particles to a value which is necessary for the required average particle size, and removing and drying the resulting pellets.

Abstract: A conveyor system has a carousel rotatable about an axis in steps and having an outer periphery along which loading, unloading, and treatment stations are spaced and a drive for rotating the carousel about the axis in steps. A plurality of fixed segments spaced along the periphery each have a straight outer edge and a plurality of movable segments spaced along the periphery are interleaved with the fixed segments and each have a straight outer edge and a pair of ends. Respective pivots secured between one of the ends of each of the movable segments and the carousel allow movement of each of the movable segments between an inner position with its outer edge nonparallel to the outer edges of adjacent fixed segments and an outer position with its outer edge parallel to the outer edge of a one of the adjacent fixed segments.

Abstract: A mouth and tooth care preparation consists of tensides, polishing agents, aromatizing agents as well as additional usual additives which are formulated in a binding agent or a mixture of binding agents consisting of water-soluble or water-swellable, physiologically acceptable film-forming agents. The mixture is formulated into a film which is pre-segmented into dosage units.

Abstract: A biconvex tablet whose height and diameter are approximately equal and are from 1.5 to 4 mm and which, besides conventional pharmaceutical auxiliaries, contains an antacid as active substance is described.

Abstract: A solid pharmaceutical sustained-release form, consisting of a core containing the active compound as well as conventional pharmaceutical auxiliaries, a coat which delays the release of the active compound and an antiadhesive outer layer, wherein the coat consists of a physiologically acceptable fat-like or wax-like hydrophobic layer which melts in the range from 30.degree. to 120.degree. C. and contains, in addition to conventional pharmaceutical auxiliaries, one or more water-insoluble polymers, and a process for its preparation.

Abstract: A pharmaceutical preparation which comprises stigmasta-4-en-3-one as the active ingredient. This active ingredient can be used for the treatment of androgen-dependent diseases, especially for the treatment of benign prostatic hyperplasia.

Abstract: The invention concerns pharmaceutical preparations containing at least one of the following compounds as an active ingredient either alone or in any desired combination: gallic acid, methyl gallate and compounds of the general formula______________________________________ ##STR1## R.sub.1 R.sub.2 R.sub.3 R.sub.4 ______________________________________ 1 galloyl galloyl galloyl H 2 galloyl digalloyl galloyl H 3 galloyl galloyl digalloyl H 4 digalloyl galloyl galloyl H 5 galloyl galloyl galloyl galloyl ______________________________________ with galloyl signifying the radical ##STR2## and diagalloyl signifying the radical ##STR3## - and the pharmaceutically acceptable salts, ethers and esters thereof. The invention further relates to a method for isolating the aforementioned compounds from the plant Galphimia Glauca. The drugs according to the invention are effective antiphlogistic agents.

Abstract: A fluid dispenser incorporating an oligodynamically germicidally active substance for maintaining the dispensation of germ-free fluid, particularly eye drops. The delivery passage from a supply container associated with the fluid dispenser of the invention contains an oligodynamically germicidally active substance that is soluble in the fluid to be dispensed. The device does not require air pressure within the container, thus eliminating one avenue for the introduction of germs into the fluid. The device includes a metering pump and inlet and outlet valves. The above-mentioned fluid soluble oligodynamically germicidally active substance is situated in the region of the inlet valve or the inlet thereto and/or the outlet therefrom.

Abstract: A pharmaceutical composition for topical application is described on the basis of a W/O emulsion, which contains piroxicam in the oil phase as an active ingredient. On account of its good compatibility to the skin and stability characteristics, the composition is very suitable for use as an antirheumatic, antiphlogistic and/or anti-inflammatory pharmaceutical.

Abstract: An apparatus for handling a plurality of elongated tubular bodies each having a small-diameter neck and a large-diameter shaft has a pair of support plates formed with respective similar arrays of throughgoing openings generally complementary to the section of the shafts of the bodies and spacers supporting the plates parallel to and spaced from each other with the openings arranged pairwise with one opening of each plate aligned along a respective axis with a respective opening of the other plate so that the bodies can be held therein. A stop plate parallel to and spaced from the support plates is formed with stop openings in an array like the openings of the support plates.

Abstract: A process for the manufacture of pellets which are composed of xanthine derivatives and are predominantly spherical, have a particle size in the range of 0.3 to 4 mm and have a bulk density above 0.5 g/cm.sup.3 by reacting the appropriate xanthine derivative with water or a water/alcohol mixture, entails anhydrous powdered xanthine derivative with an average particle size of from 20 to 200 .mu.m being suspended by stirring at from 40.degree. to 70.degree. C. in a nonsolvent which is immiscible with water and has a boiling point in the range from 60.degree. to 160.degree. C., then adding from 10 to 40% by weight, based on the anhydrous xanthine derivative, of water or a water/alcohol mixture and subsequently allowing to cool to room temperature at from 5.degree. to 20.degree. C.

Abstract: A hypodermic-syringe assembly comprises a hard tubular body centered on an axis and having an axial front end formed with a radially inwardly projecting annular ridge and an axial rear end, a piston axially slidable in the body and normally adjacent the rear end, and a soft plug fitted in the front end in tight engagement with the ridge. The plug is formed with an axially rearwardly open blind passage having a front floor, and a front face defining with the passage floor a relatively thin membrane. Thus a needle can be poked through the membrane.

Abstract: A hypodermic syringe assembly has a hollow body having a neck centered on an axis, an elastomeric plug fitted in the neck and having an end projecting axially forward from the neck, a stiffening sleeve fitted over the plug and neck and having a collar fitting around the projecting plug end and itself projecting axially therepast, an elastomeric stopper fitted into the collar, and a protective cap fitted over the plug, sleeve, and stopper. A destructible connection between the cap and the sleeve retains the cap in place on the body over the plug, sleeve, and stopper. This cap is therefore only removable from the body by destruction of the connection. The protective cap is basically cylindrical and centered on the axis and has a front end wall generally transverse of the axis and an opposite rear end edge and the destructible connection extends annularly between the end edge of the cap and the sleeve.

Abstract: Pharmaceutical combination preparations containing rifampicin and thioacetazon and optionally isonicotinic acid hydrazide or ethambutol and the use of same for the treatment of mycobacterial infections.

Abstract: A hypodermic syringe has a generally cylindrically tubular body extending along an axis and having an axial front end formed with a radially outwardly projecting annular bead, a piston axially displaceable in the body, a plug having a rearwardly directed flange fitting complementarily over the front end of the body at the bead and forwardly blocking the body, and a flat soft seal ring compressed axially between the plug and the front end of the body. The body has a rear end provided with a finger-rest crosspiece and the piston is provided with a plunger projecting axially out the rear end past the crosspiece.