Patent number: 6028053
Abstract: A peptide of the formula (I): X.sup.1 -A.sup.1 -A.sup.2 -X.sup.2 -Asn-X.sup.3 -X.sup.4 -P.Tyr-X.sup.5 -X.sup.6 -X.sup.7 -X.sup.8, wherein X.sup.1 represents Lys, Arg, His, Ser, Thr, Tyr, Asn, Leu, Val or Glu, A.sup.1 represents Trp, Leu, Ala, Ser, Ile, Glu, Met, Gly, Cys, Phe, Pro or Val, and A.sup.2 represents Ala, Val, Leu, Ile, Ser, Met, Phe, Gly, Cys, Trp or Pro, X.sup.2 represents Glu, Asn, Tyr, Thr, Ser, Asp or Ile, X.sup.3 represents Pro, Met, Trp, Phe, Ala, Lys, Val, Leu, Ile, Gly or Ser, X.sup.6 represents Ser, Thr, Tyr, Asn, Glu, Met, Ala, Leu, Val or Gly, X.sup.7 represents Asp, Glu, Ala, Val, Leu, Ile, Gly, Cys, Phe, Trp, Met, Pro, Ser or Asn and X.sup.8 which may be present or absent represents Phe, Trp, Pro, Leu, Ala, Val, Ile, Gly, Cys, Met, Asp, Ser or Arg which interferes with the interaction of a PTB domain containing protein with a PTB domain binding site, and truncations and analogues of the peptide.
Type:
Grant
Filed:
April 22, 1998
Date of Patent:
February 22, 2000
Assignees:
Mount Sinai Hospital Corporation, Asahi Chemical Industry Co., Ltd.
Inventors:
Peter van der Geer, Sandra Wiley, Gerald Gish, Anthony Pawson, Kazunori Toma