Abstract: The present invention relates generally to a system and methods for medical reporting. More specifically, the invention is directed to a system that includes a structured reference frame component through the use of which one or more anatomical features or pathologies that are shown on an actual image taken of a patient can be associated with the data and other information provided in a structured knowledge base. Certain embodiments of the system include a structured reference frame component that can be used for a plurality of medical images taken of a patient, the plurality of images being ones taken, for example, of different views or projections or at different times to provide what is termed for purposes of this application a structured image set. Advantageously, such a structured image set places the subject anatomical feature or pathology in a greater spatial and/or temporal context.