Patents Assigned to AsclepiX Therapeutics, Inc.
  • Methods for identifying and preparing pharmaceutical agents for activating Tie1 and/or Tie2 receptors
    Patent number: 11674959
    Abstract: The present invention in various aspects and embodiments involves pharmaceutical compositions prepared by contacting a candidate ?- or ?-integrin-binding molecule, or panel thereof, with an integrin heterodimer, and quantifying heterodimer disruption by the candidate molecule. An integrin-binding molecule, or derivative thereof, that disrupts the integrin heterodimer is selected and is formulated into a pharmaceutical composition for administration to a subject, e.g., who has a disease or disorder related to abnormal vascularization.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: June 13, 2023
    Assignees: The Johns Hopkins University, AsclepiX Therapeutics, Inc.
    Inventors: Niranjan Pandey, Aleksander S. Popel, Jordan J. Green, Adam Mirando