Abstract: Magnetically coupled mixer having an impeller magnetically coupled to a drive shaft and thrust bearings that support the impeller. The drive shaft can be moved along its axis, and an upwardly directed axial force is applied to the drive shaft to partially offset downward forces exerted by the impeller and thereby reduce friction between the thrust bearing surfaces while maintaining contact between them. In one disclosed embodiment, the force is applied to the drive shaft by a pair of magnets arranged so that the magnetic fields interact to produce the force, and the magnitude of the force is controlled by adjusting the distance between the magnets. The forces exerted by the impeller can be monitored and utilized in controlling the magnitude of the force applied to the shaft.

Abstract: Magnetically coupled mixer having an impeller magnetically coupled to a drive shaft and thrust bearings that support the impeller. The drive shaft can be moved along its axis, and an upwardly directed axial force is applied to the drive shaft to partially offset downward forces exerted by the impeller and thereby reduce friction between the thrust bearing surfaces while maintaining contact between them. In one disclosed embodiment, the force is applied to the drive shaft by a pair of magnets arranged so that the magnetic fields interact to produce the force, and the magnitude of the force is controlled by adjusting the distance between the magnets. The forces exerted by the impeller can be monitored and utilized in controlling the magnitude of the force applied to the shaft.

Abstract: Inline valve assembly having a body with an axial bore and guide slots extending in a direction perpendicular to the bore, a flexible tubular liner having an axially extending flow passageway with a generally cylindrical side wall disposed in and supported by the bore, throttling pins mounted in the guide slots in engagement with the side wall on opposite sides of the liner, and cam members rotatively mounted on the valve body for urging the pins together against the side wall to restrict flow through the passageway.

Abstract: Aseptic connector which has a body, an axially extending opening in the body, a seat surrounding the opening for receiving the connecting flange of a fitting, and a clamp for pressing the flange into the seat. The seat has a radially extending sealing surface with an annular outer portion and a conically inclined inner lip that extends inwardly and upwardly from the annular portion toward the opening.

Abstract: Manifold and probe assembly for use a bioprocessing vessel. The manifold has a chamber which communicates with the interior of the vessel and a plurality of ports which communicate with the chamber. Elongated sensing probes are threadedly connected to the ports with end portions of the probes extending into the chamber. Gaskets having generally annular bodies with conically inclined beveled faces are mounted on the end portions of the probes, with the beveled faces engaging conically inclined surfaces of seats in the ports and the gaskets being axially compressed and radially expanded into sealing engagement with the probes. The seating surfaces have inner and outer sections with different angles of inclination which produce greater radial expansion and tighter sealing with the probes.

Abstract: Manifold and probe assembly for use a bioprocessing vessel. The manifold has a chamber which communicates with the interior of the vessel and a plurality of ports which communicate with the chamber. Elongated sensing probes are threadedly connected to the ports with end portions of the probes extending into the chamber. Gaskets having generally annular bodies with conically inclined beveled faces are mounted on the end portions of the probes, with the beveled faces engaging conically inclined surfaces of seats in the ports and the gaskets being axially compressed and radially expanded into sealing engagement with the probes. The seating surfaces have inner and outer sections with different angles of inclination which produce greater radial expansion and tighter sealing with the probes.

Abstract: Aseptic connector which has a body, an axially extending opening in the body, a seat surrounding the opening for receiving the connecting flange of a fitting, and a clamp for pressing the flange into the seat.