Abstract: We describe a user exercise-tolerance measuring pulse oximeter system, for determining the exercise tolerance or capacity of a user undergoing exercise, the system comprising: a wireless fingerband comprising an optical sensor to provide an oxygen saturation signal, a chargeable power supply, and a wireless transmitter/receiver; a motion detector to provide a user motion signal; and a signal processor coupled to said wireless fingerband to data from said optical sensor, and coupled to said motion detector; wherein said signal processor is configured to: process a combination of said oxygen saturation signal and said user motion signal to determine exercise tolerance data, wherein said exercise tolerance data is dependent upon said oxygen saturation signal and a level of exertion of said user determined from said user motion signal; and to time or count a period or quantity of user motion or movements, during said exercise, identified by said motion detector, to determine said level of exertion; to measure a d

Abstract: We describe a user exercise-tolerance measuring pulse oximeter system, for determining the exercise tolerance or capacity of a user undergoing exercise, the system comprising: a wireless fingerband comprising an optical sensor to provide an oxygen saturation signal, a chargeable power supply, and a wireless transmitter/receiver; a motion detector to provide a user motion signal; and a signal processor coupled to said wireless fingerband to data from said optical sensor, and coupled to said motion detector; wherein said signal processor is configured to: process a combination of said oxygen saturation signal and said user motion signal to determine exercise tolerance data, wherein said exercise tolerance data is dependent upon said oxygen saturation signal and a level of exertion of said user determined from said user motion signal; and to time or count a period or quantity of user motion or movements, during said exercise, identified by said motion detector, to determine said level of exertion; to measure a d

Abstract: Methods of determining levels of activity of bacteria in the lungs of patients are described, in which levels of a marker of a bacterial iron scavenging processes (for example, siderophores) and levels of a secreted bacterial protein are measured over time. Changes in the measured levels over time allow levels of bacterial activity to be determined, and exacerbations of bacterial infection to be predicted and/or monitored. Additional markers may also be used. The methods of the invention may also be used for monitoring effectiveness of antibiotic treatment of lung infection. The invention is particularly useful for monitoring P. aeruginosa levels in lungs of cystic fibrosis patients. Kits for use in the methods are also described.

Abstract: Methods of determining levels of activity of bacteria in the lungs of patients are described, in which levels of a marker of a bacterial iron scavenging processes (for example, siderophores) and levels of a secreted bacterial protein are measured over time. Changes in the measured levels over time allow levels of bacterial activity to be determined, and exacerbations of bacterial infection to be predicted and/or monitored. Additional markers may also be used. The methods of the invention may also be used for monitoring effectiveness of antibiotic treatment of lung infection. The invention is particularly useful for monitoring P. aeruginosa levels in lungs of cystic fibrosis patients. Kits for use in the methods are also described.