Patents Assigned to Asociación Centro De Investigación Cooperativa
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Patent number: 11906604Abstract: An apparatus to detect and measure a T-MOKE signal includes a first linear polarizer located on the optical path between a light source and a reflecting surface of a sample, a device to produce a magnetic field at the sample location, the device being configured to direct the magnetization perpendicularly to the optical plane of incidence and to reverse the direction of the magnetic field, a rotatable quarter-wave plate located after the reflecting surface on the optical path of the reflected light, a second linear polarizer that is rotatable and is located after the quarter-wave plate on the optical path of the reflected light, and a photo-detector located after the second linear polarizer on the optical path of the reflected light, the photo-detector being configured to measure the intensity of the light. A method for extracting a T-MOKE signal in an ellipsometric measurement procedure employs such an apparatus.Type: GrantFiled: October 29, 2021Date of Patent: February 20, 2024Assignee: ASOCIACIÓN CENTRO DE INVESTIGACIÓN COOPERATIVA EN NANOCIENCIAS “CIC NANOGUNE”Inventors: Eva Oblak, Patricia Riego Saavedra, Andreas Berger, Aitor García Manso, Ane Martínez De Guereñu Elorza, Fernando Arizti, Andoni Irizar Picón
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Patent number: 11493323Abstract: Methods and apparatus are provided for imaging a response of a sample to radiative heating. A method in accordance with one embodiment has steps of: illuminating a first area of the sample with a radiative heating beam; illuminating a portion of the first area with a probe beam; collecting light exiting the sample due to interaction of the probe beam with the sample; superimposing the light exiting the sample with a reference beam derived from the probe beam, wherein the reference is characterized by an optical phase relative to the probe beam; detecting a spatial portion of the light exiting the sample and the reference beam with at least one detector to generate an interference signal; and processing the interference signal to obtain an image of the sample associated with absorption of the radiative heating beam.Type: GrantFiled: January 3, 2020Date of Patent: November 8, 2022Assignees: The Board of Trustees of the University of Illinois, Asociación Centro De Investigación CooperativaInventors: Martin Schnell, Paul Scott Carney, Rohit Bhargava
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Patent number: 11444218Abstract: The present invention relates to a device for operating with THz and/or IR and/or MW radiation, comprising: —an antenna having one or more antenna branches (A1; A1, A2) and adapted to operate in the THz and/or IR and/or MW frequency range; and —a structure made of at least one photoactive material defining a photo-active area (Ga) arranged to absorb light radiation impinging thereon. The focus area of the at least one antenna branch (A1; A1, A2) is dimensionally equal or smaller than the photo-active area (Ga).Type: GrantFiled: December 24, 2018Date of Patent: September 13, 2022Assignees: FUNDACIÓ INSTITUT DE CIÈNCIES FOTÓNIQUES, INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS, ASOCIACIÓN CENTRO DE INVESTIGACIÓN COOPERATIVA EN NANOCIENCIAS, CIC NANOGUNEInventors: Klaas-Jan Tielrooij, Frank Koppens, Rainer Hillenbrand, Marta Autore
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Patent number: 11377475Abstract: The present invention refers to a protein-stabilized metal nanocluster comprising a variant of the helix A of the CTPR. It is also related to its uses for delivering of a drug, for interfering a metabolic reaction, for catalyzing a chemical reaction, as biocatalyst, for detecting an analyte, for phasing crystallographic data set, for cell labeling, for specific protein labeling, as biosensor, as a temperature sensor, as photosensitizer, or for the manufacture of an optoelectronic device.Type: GrantFiled: July 10, 2018Date of Patent: July 5, 2022Assignee: ASOCIACIÓN CENTRO DE INVESTIGACIÓN COOPERATIVA EN BIOMATERIALES—CIC BIOMAGUNEInventors: Aitziber López Cortajarena, Antonio Aires Trapote
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Patent number: 11337966Abstract: The present invention relates to the use of the compound ciclopirox or a pharmaceutically acceptable salt or solvate thereof for the treatment and/or prevention of a disease caused by dysregulated heme group biosynthesis, with the proviso that said disease is not congenital erythropoietic porphyria.Type: GrantFiled: April 27, 2018Date of Patent: May 24, 2022Assignee: ASOCIACIÓN CENTRO DE INVESTIGACIÓN COOPERATIVA EN BIOCIENCIAS-CIC BIOGUNEInventors: Oscar Millet Aguilar-Galindo, Arantza Sanz Parra, Ana Laín Torre, Pedro David Urquiza Ortiz, Juan Manuel Falcón Pérez, Joaquín Castilla Castrillón, Itxaso San Juan Quintana, Ganeko Bernardo-Seisdedos
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Patent number: 11242514Abstract: The invention relates to an endocellulase catalytic domain comprising the sequence of SEQ ID NO: 1 or a functionally equivalent variant of said catalytic domain that substantially maintains or improves its catalytic activity. The invention also relates to a polypeptide, a nucleic acid, an expression cassette, a vector or a host cell. Additionally, the invention relates to the use of an endocellulase catalytic domain or the polypeptide of the invention for hydrolysing cellulose, producing bioethanol or as a detergent. The invention also relates to a method for hydrolysing cellulose and for producing bioethanol.Type: GrantFiled: January 16, 2017Date of Patent: February 8, 2022Assignee: Asociación Centro de Investigación Cooperativa en Nanociencias “CIC nanoGUNE”Inventor: Raúl Pérez-Jiménez
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Publication number: 20210376181Abstract: The present invention relates to a device for operating with THz and/or IR and/or MW radiation, comprising:—an antenna having one or more antenna branches (A1; A1, A2) and adapted to operate in the THz and/or IR and/or MW frequency range; and—a structure made of at least one photoactive material defining a photo-active area (Ga) arranged to absorb light radiation impinging thereon. The focus area of the at least one antenna branch (A1; A1, A2) is dimensionally equal or smaller than the photo-active area (Ga).Type: ApplicationFiled: December 24, 2018Publication date: December 2, 2021Applicants: FUNDACIÓ INSTITUT DE CIÈNCIES FOTÒNIQUES, FUNDACIÓ INSTITUT DE CIÈNCIES FOTÒNIQUES, INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS, INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS, ASOCIACIÓN CENTRO DE INVESTIGACIÓN COOPERATIVA EN NANOCIENCIAS, CIC NANOGUNE, ASOCIACIÓN CENTRO DE INVESTIGACIÓN COOPERATIVA EN NANOCIENCIAS, CIC NANOGUNEInventors: Klaas-Jan Tielrooij, Frank Koppens, Rainer Hillenbrand, Marta Autore
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Patent number: 10849994Abstract: There is provided a process for the preparation of a pharmaceutical composition comprising an 18F-labelled gas selected from the group consisting of 18F-labelled sulphur hexafluoride ([18F]SF6) and 18F-labelled carbon tetrafluoride ([18F]CF4), comprising the steps: a) Filling a target with a gas mixture comprising a fluorinated gas selected from the group consisting of sulphur hexafluoride (SF6) and carbon tetrafluoride (CF4); b) Irradiating the gas mixture of step a) with protons with energies from 0.1 to 50 MeV. The pharmaceutical composition obtainable by the process and its uses in diagnosis, prognosis and lung function studies based on positron emission tomography (PET) are also claimed.Type: GrantFiled: June 27, 2017Date of Patent: December 1, 2020Assignee: ASOCIACIÓN CENTRO DE INVESTIGACIÓN COOPERATIVA EN BIOMATERIALES — CIC BIOMAGUNEInventors: Jordi Llop Roig, Vanessa Gómez Vallejo, Torsten Reese, Aitor Lecuona Fernändez
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Publication number: 20200283770Abstract: Methods and compounds useful to treat drug-induced diseases and conditions are provided. Methods of administering one or more MCJ-inhibiting compounds to decrease MCJ polypeptide activity in cells, tissues, and/or subjects as a treatment for a drug-induced disease or condition are provided.Type: ApplicationFiled: May 18, 2020Publication date: September 10, 2020Applicants: University of Vermont and State Agricultural College, Asociacion Centro de Investigacion Cooperativa en Biociencias-CIC bioGUNEInventors: Mercedes Rincon, Maria Luz Martinez Chantar, Juan Anguita, Oliver Dienz
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Patent number: 10655126Abstract: Methods and compounds useful to treat drug-induced diseases and conditions are provided. Methods of administering one or more MCJ-inhibiting compounds to decrease MCJ polypeptide activity in cells, tissues, and/or subjects as a treatment for a drug-induced disease or condition are provided.Type: GrantFiled: July 9, 2016Date of Patent: May 19, 2020Assignees: University of Vermont and State Agricultural College, Asociacion Centro de Investigacion Cooperativa en Biociencias-CIC bioGuneInventors: Mercedes Rincon, Maria Luz Martinez Chantar, Juan Anguita, Oliver Dienz
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Patent number: 10457941Abstract: Methods and compounds useful to treat diseases and conditions are provided. Methods of administering one or more microRNA-inhibitor compounds or one or more microRNA-enhancing compounds to cells, tissues, and/or subjects as a treatment for a disease or condition are provided.Type: GrantFiled: August 20, 2016Date of Patent: October 29, 2019Assignee: Asociacion Centro de Investigacion Cooperativa en Biociencias-CIC bioGUNEInventors: Maria Luz Martinez Chantar, Juan Anguita
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Patent number: 10427121Abstract: A device for non intrusive agitation of a fluid is provided, including a container adapted to contain the fluid, at least one of the walls thereof includes a membrane and a main movable stirring means inside the container adapted to stir at least the fluid. The first flexible element is adapted to interfere mechanically with an external movable impulsion means, thus creating a deformation which has a mechanical interference with the main movable stirring means. This movement of such impulsion means is transmitted to the main movable stirring means by the interposition of the first flexible element.Type: GrantFiled: February 1, 2013Date of Patent: October 1, 2019Assignee: ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES (CIC biomaGUNE)Inventor: Marcos Simon Soria
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Patent number: 10420755Abstract: The present invention relates to the use of the compound ciclopirox or a pharmaceutically acceptable salt or solvate thereof for the treatment and/or prevention of congenital erythropoietic porphyria (CEP).Type: GrantFiled: October 27, 2017Date of Patent: September 24, 2019Assignee: ASOCIACIÓN CENTRO DE INVESTIGACIÓN COOPERATIVA EN BIOCIENCIAS-CIC BIOGUNEInventors: Oscar Millet Aguilar-Galindo, Arantza Sanz Parra, Ana Laín Torre, Pedro David Urquiza Ortiz, Juan Manuel Falcón Pérez
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Patent number: 10295560Abstract: The invention relates to a device for conducting near-field optical measurements of a sample comprising a wavelength-tunable monochromatic light source. Further the invention relates to methods for measuring the near-field using such a device.Type: GrantFiled: March 10, 2016Date of Patent: May 21, 2019Assignee: ASOCIACION CENTRO DE INVESTIGACIÓN COOPERATIVA EN NANOSCIENCIAS (CIC NANOGUNE)Inventors: Edward Yoxall, Martin Schnell, Rainer Hillenbrand
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Publication number: 20190078086Abstract: Methods and compounds useful to treat drug-induced diseases and conditions are provided. Methods of administering one or more MCJ-inhibiting compounds to decrease MCJ polypeptide activity in cells, tissues, and/or subjects as a treatment for a drug-induced disease or condition are provided.Type: ApplicationFiled: July 9, 2016Publication date: March 14, 2019Applicants: University of Vermont and State Agricultural College, Asociacion Centro de Investigacion Cooperativa en Biociencias-CIC bioGUNEInventors: Mercedes Rincon, Maria Luz Martinez Chantar, Juan Anguita, Oliver Dienz
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Publication number: 20180245080Abstract: Methods and compounds useful to treat diseases and conditions are provided. Methods of administering one or more microRNA-inhibitor compounds or one or more microRNA-enhancing compounds to cells, tissues, and/or subjects as a treatment for a disease or condition are provided.Type: ApplicationFiled: August 20, 2016Publication date: August 30, 2018Applicant: Asociacion Centro de Investigacion Cooperativa en Biociencias-CIC bioGUNEInventors: Maria Luz MARTINEZ CHANTAR, Juan ANGUITA
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Patent number: 9434765Abstract: The potential use of these “SUMO receptors” to isolate SUMOylated targets has been considered using the SIM sequences of the SUMO-dependent ubiquitin-protein ligase RNF4. RFN4 contains 4 SIM sequences known to interact with SUMOylated proteins. The capacity of the SIM2 and SIM3 of RNF4 to purify SUMOylated proteins was increased when in the present invention it was disposed in tandem up to 4 SIM sequences. In a preferred embodiment to increase flexibility and functionality of this SUMO-trap, we have changed the natural linkers resulting in a broader capture of SUMOylated proteins. This Tandem SUMO Interacting Motifs (TSIMs) or SUMO-Binding Entities (SUBEs) system disclosed in the present invention is useful to capture polySUMOylated proteins from cell extracts. Therefore, in another embodiment of the present invention, TSIMs or SUBEs can be used for the identification SUMO substrates and the study of SUMO-regulated processes.Type: GrantFiled: March 8, 2012Date of Patent: September 6, 2016Assignee: ASOCIACIÓN CENTRO DE INVESTIGACIÓN COOPERATIVA EN BIOCIENCIAS-CIC BIOGUNEInventor: Manuel Salvador Rodríguez Medina
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Patent number: 9334526Abstract: The present invention disclosed the cloning and the purification of a mutant of prethrombin-2, which contains a thrombin cleavage site instead of a factor Xa cleavage site. The stable mutant prethrombin-2 is able to convert itself autocatalytically into active ?-thrombin in the absence of ecarin or factor Xa. The new concept of signal amplification using self-replicating enzymes can be applied to improve sensitivity of ?-thrombin assays and also for the preparation of different enzymes.Type: GrantFiled: October 31, 2012Date of Patent: May 10, 2016Assignee: ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES-CICInventors: Valery Pavlov, Laura Saa Peña, Ana Virel Sánchez
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Publication number: 20150367303Abstract: A device for non intrusive agitation of a fluid is provided, including a container adapted to contain the fluid, at least one of the walls thereof includes a membrane and a main movable stirring means inside the container adapted to stir at least the fluid. The first flexible element is adapted to interfere mechanically with an external movable impulsion means, thus creating a deformation which has a mechanical interference with the main movable stirring means. This movement of such impulsion means is transmitted to the main movable stirring means by the interposition of the first flexible element.Type: ApplicationFiled: February 1, 2013Publication date: December 24, 2015Applicant: ASOCIACIÓN CENTRO DE INVESTIGACIÓN COOPERATIVA EN BIOMATERIALES (CIC biomaGUNE)Inventor: Marcos SIMON SORIA
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Patent number: 9138423Abstract: The invention relates to the use of a compound of general formula (I), wherein R1 and R2 are independently H or C1-C6 alkyl, or R1 and R2 are bound to one another forming an optionally substituted fused benzene ring, R3 is H, C1-C6 alkyl or —CH2— CH(NH2)—COOH and R4 is H, C1-C6 alkyl, or R4 represents (II) or (III) in the preparation of a medicinal product for treating and/or preventing congenital erythropoietic porphyria (CEP).Type: GrantFiled: August 5, 2011Date of Patent: September 22, 2015Assignee: Asociación Centro de Investigación Cooperativa en Biociencias—CIC BioguneInventors: Oscar Millet Aguilar-Galindo, Ana Laín Torre