Abstract: There is provided a stable pharmaceutical formulation comprising (a) an effective amount of levothyroxine sodium, (b) microcrystalline cellulose which has a mean particle size of less than 125 ?m and is present in an amount of 60 to 85% w/w based upon the total weight of the formulation, and (c) pregelatinised starch present in an amount of 5 to 30% w/w based upon total weight of the formulation. There is also provided a process for the preparation of such a formulation.
Type:
Grant
Filed:
July 8, 2004
Date of Patent:
June 7, 2011
Assignee:
Aspen Global Incorporated
Inventors:
Malgorzata Konieczna, Heiner Krohn, Wanda Roman, Hendrik Schlehahn, Malgorzata Anna Strozyk