Patents Assigned to AspenBio Pharma, Inc.
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Patent number: 10105417Abstract: This invention provides methods and kits for maintaining pregnancy in mammals. Pregnancy is maintained by administration of effective amounts of luteinizing hormone (LH) or chorionic gonadotropin (CG). Both LH and CG may be used alone, in combination with each other, or in combination with growth hormone (GH) or follicle stimulating hormone (FSH). Hormones are administered on about Day 4 to about Day 7 following insemination. Effective amounts of LH range from about 10 micrograms to about 25 milligrams, preferably about 2 to about 8 mg, and of CG range from about 100 IU (international units) to about 2000 IU. Mammals treatable by the methods of this invention include ungulates and related mammals, including bovines. Kits provided by this invention include effective amounts of one or more hormones, a device for administering the hormone(s) and instructions. This invention also provides methods for treating follicular cysts and for synchronizing ovulation in mammals using LH.Type: GrantFiled: March 4, 2004Date of Patent: October 23, 2018Assignee: AspenBio Pharma, Inc.Inventors: Kevin McSweeney, Mark Colgin, Diane Newman, Jay W. Roth, Roger Hurst
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Patent number: 8518881Abstract: The present invention provides methods of producing biologically active recombinant bFSH and methods of increasing reproduction in mammals, particularly bovine, using recombinant bFSH. Also provided are methods of producing single chain recombinant bFSH. The recombinant bFSH of the present invention increases superovulation, embryo development, and reproductive efficiency in cattle and other ungulates.Type: GrantFiled: February 8, 2008Date of Patent: August 27, 2013Assignee: AspenBio Pharma, Inc.Inventors: Mark A. Colgin, Richard G. Donnelly, Brad Stroud
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Publication number: 20130122528Abstract: The invention relates to methods, devices and systems for assessing appendicitis in a subject. More particularly, this invention relates to methods, devices and systems for assessing appendicitis in a subject by evaluating multiple biomarkers in a sample from the subject and comparing the values of the biomarker to a reference value from a group having high or low risk for appendicitis, or combining the values of the biomarkers using a mathematical algorithm to produce a numerical test score, and comparing the test score to a reference value to assess appendicitis in the subject.Type: ApplicationFiled: November 16, 2012Publication date: May 16, 2013Applicant: AspenBio Pharma, Inc.Inventor: AspenBio Pharma, Inc.
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Patent number: 7842513Abstract: This invention provides methods and compositions for testing for pregnancy and non-pregnancy in ungulates and non-hoofed ruminates. The tests provided by this invention are useful during a time that coincides with the estrus cycle during which breeding occurs or the first estrus cycle after breeding of a non-pregnant animal. The tests provided by this invention are useful in estrus and ovulation synchronization programs, with pregnancy testing useful at a time allowing for resynchronization of non-pregnant animals within the first estrus cycle. The tests provided by this invention assay for the presence, absence, or level of a selected IFN-?-induced protein in a sample from a female animal. The tests of this invention are useful for testing cells, blood, plasma, serum, cells, milk, nasal secretions, ocular secretions, vaginal secretions, urine, and saliva samples. The tests provided by this invention are immunoassays.Type: GrantFiled: May 2, 2003Date of Patent: November 30, 2010Assignees: AspenBio Pharma, Inc., University of WyomingInventors: Mark Colgin, Diane Newman, Cathy Landmann, Jay W. Roth, Roger Hurst, Thomas R. Hansen, Kathleen Jeanette Austin
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Publication number: 20100184070Abstract: A method is provided for diagnosing appendicitis in a patient that includes identifying at least one symptom of appendicitis in the patient and identifying the presence of at least one molecule differentially associated with appendicitis in a fluid or tissue sample of said patient. MRP-8/14 and haptoglobin are examples of molecules differentially associated with appendicitis. Devices and kits for performing the appendicitis assays of this invention are also provided. In one embodiment, the device is in a flow-through immunoassay format for testing blood samples. Further, methods for screening for molecules differentially associated with appendicitis are provided that include the use of samples from patients being operated on for suspected appendicitis.Type: ApplicationFiled: January 20, 2010Publication date: July 22, 2010Applicant: AspenBio Pharma, Inc.Inventors: Mark A. Colgin, John F. Bealer, Richard G. Donnelly, Diane Newman
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Publication number: 20100136588Abstract: A method is provided for determining the severity of appendicitis in a patient that includes testing a blood, serum or plasma sample from the patient for the quantity of MRP8/14 in the sample and comparing it with the quantity of MRP8/14 present in standard samples correlated with an appendicitis severity scoring system. A histologically-based appendicitis severity scoring system is also provided. Immunoassays and kits for performing the appendicitis assays of this invention are also provided, as are standard samples and data correlating MRP8/14 quantities present in patient samples to histologically-based appendicitis severity grades. The methods and immunoassay devices and kits of this invention are useful for managing the treatment of patients presenting with appendicitis symptoms.Type: ApplicationFiled: December 15, 2009Publication date: June 3, 2010Applicant: AspenBio Pharma, Inc.Inventors: Mark A. Colgin, John F. Bealer, Richard G. Donnelly
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Publication number: 20100120677Abstract: The present invention provides methods of producing biologically active recombinant eFSH analogs and methods of increasing reproduction in mammals, particularly equine, using recombinant eFSH analogs. Also provided are methods of producing biologically active single chain recombinant eFSH. The recombinant eFSH analogs of the present invention increase superovulation, follicular development, embryo development, and reproductive efficiency in horses, cattle and other ungulates.Type: ApplicationFiled: November 28, 2008Publication date: May 13, 2010Applicant: AspenBio Pharma Inc.Inventors: Mark COLGIN, Irving Boime, Janet Roser, Kory Niswender
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Patent number: 7687281Abstract: This invention provides bovine pregnancy test methods and devices. The test is also suitable for other ruminant and/or ungulate animals. Antigens from Group A (early pregnancy antigens), and/or Group B (mid-pregnancy antigens), and Group C (early, mid- and late pregnancy antigens) are detected in a fluid from the animal, and pregnancy is reliably determined. The pregnancy assays of this invention are preferably carried out using immunoassay devices which provide immediate results in the field.Type: GrantFiled: March 13, 2007Date of Patent: March 30, 2010Assignee: AspenBio Pharma, Inc.Inventors: Jay W. Roth, Roger Hurst, Diane Newman, Cathy Landmann, Mark Colgin
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Patent number: 7670789Abstract: A method is provided for diagnosing appendicitis in a patient that includes identifying at least one symptom of appendicitis in the patient and identifying the presence of at least one molecule differentially associated with appendicitis in a fluid or tissue sample of said patient. MRP-8/14 and haptoglobin are examples of molecules differentially associated with appendicitis. Devices and kits for performing the appendicitis assays of this invention are also provided. In one embodiment, the device is in a flow-through immunoassay format for testing blood samples. Further, methods for screening for molecules differentially associated with appendicitis are provided that include the use of samples from patients being operated on for suspected appendicitis.Type: GrantFiled: February 11, 2009Date of Patent: March 2, 2010Assignee: AspenBio Pharma, Inc.Inventors: Mark A. Colgin, John F. Bealer, Richard G. Donnelly, Diane Newman
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Patent number: 7659087Abstract: A method is provided for determining the severity of appendicitis in a patient that includes testing a blood, serum or plasma sample from the patient for the quantity of MRP8/14 in the sample and comparing it with the quantity of MRP8/14 present in standard samples correlated with an appendicitis severity scoring system. A histologically-based appendicitis severity scoring system is also provided. Immunoassays and kits for performing the appendicitis assays of this invention are also provided, as are standard samples and data correlating MRP8/14 quantities present in patient samples to histologically-based appendicitis severity grades. The methods and immunoassay devices and kits of this invention are useful for managing the treatment of patients presenting with appendicitis symptoms.Type: GrantFiled: February 2, 2007Date of Patent: February 9, 2010Assignee: AspenBio Pharma, Inc.Inventors: Mark A. Colgin, John F. Bealer, Richard G. Donnelly
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Publication number: 20090155813Abstract: A method is provided for diagnosing appendicitis in a patient that includes identifying at least one symptom of appendicitis in the patient and identifying the presence of at least one molecule differentially associated with appendicitis in a fluid or tissue sample of said patient. MRP-8/14 and haptoglobin are examples of molecules differentially associated with appendicitis. Devices and kits for performing the appendicitis assays of this invention are also provided. In one embodiment, the device is in a flow-through immunoassay format for testing blood samples. Further, methods for screening for molecules differentially associated with appendicitis are provided that include the use of samples from patients being operated on for suspected appendicitis.Type: ApplicationFiled: February 11, 2009Publication date: June 18, 2009Applicant: AspenBio Pharma, Inc.Inventors: Mark A. Colgin, John F. Bealer, Richard Donnelly, Diane Newman
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Patent number: 7501256Abstract: A method is provided for diagnosing appendicitis in a patient that includes identifying at least one symptom of appendicitis in the patient and identifying the presence of at least one molecule differentially associated with appendicitis in a fluid or tissue sample of said patient. MRP-8/14 and haptoglobin are examples of molecules differentially associated with appendicitis. Devices and kits for performing the appendicitis assays of this invention are also provided. In one embodiment, the device is in a flow-through immunoassay format for testing blood samples. Further, methods for screening for molecules differentially associated with appendicitis are provided that include the use of samples from patients being operated on for suspected appendicitis.Type: GrantFiled: July 25, 2005Date of Patent: March 10, 2009Assignee: AspenBio Pharma, Inc.Inventors: Mark A. Colgin, John F. Bealer, Richard Donnelly, Diane Newman
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COMPOSITIONS AND METHODS INCLUDING EXPRESSION AND BIOACTIVITY OF BOVINE FOLLICLE STIMULATING HORMONE
Publication number: 20080312151Abstract: The present invention provides methods of producing biologically active recombinant bFSH and methods of increasing reproduction in mammals, particularly bovine, using recombinant bFSH. Also provided are methods of producing single chain recombinant bFSH. The recombinant bFSH of the present invention increases superovulation, embryo development, and reproductive efficiency in cattle and other ungulates.Type: ApplicationFiled: February 8, 2008Publication date: December 18, 2008Applicant: AspenBio Pharma, Inc.Inventors: Mark A. COLGIN, Richard G. Donnelly, Brad Stroud -
Patent number: 7393696Abstract: This invention provides bovine pregnancy test methods and devices. The test is also suitable for other ruminant and/or ungulate animals. Antigens from Group A (early pregnancy antigens), and/or Group B (mid-pregnancy antigens), and Group C (early, mid- and late pregnancy antigens) are detected in a fluid from the animal, and pregnancy is reliably determined. The pregnancy assays of this invention are preferably carried out using immunoassay devices which provide immediate results in the field.Type: GrantFiled: September 24, 2002Date of Patent: July 1, 2008Assignee: AspenBio Pharma, Inc.Inventors: Jay W. Roth, Mark Colgin, Roger Hurst, Diane Newman, Cathy Landmann
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Publication number: 20070249003Abstract: A method is provided for determining the severity of appendicitis in a patient that includes testing a blood, serum or plasma sample from the patient for the quantity of MRP8/14 in the sample and comparing it with the quantity of MRP8/14 present in standard samples correlated with an appendicitis severity scoring system. A histologically-based appendicitis severity scoring system is also provided. Immunoassays and kits for performing the appendicitis assays of this invention are also provided, as are standard samples and data correlating MRP8/14 quantities present in patient samples to histologically-based appendicitis severity grades. The methods and immunoassay devices and kits of this invention are useful for managing the treatment of patients presenting with appendicitis symptoms.Type: ApplicationFiled: February 2, 2007Publication date: October 25, 2007Applicant: AspenBio Pharma, Inc.Inventors: Mark Colgin, John Bealer, Richard Donnelly
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Publication number: 20070184558Abstract: This invention provides bovine pregnancy test methods and devices. The test is also suitable for other ruminant and/or ungulate animals. Antigens from Group A (early pregnancy antigens), and/or Group B (mid-pregnancy antigens), and Group C (early, mid- and late pregnancy antigens) are detected in a fluid from the animal, and pregnancy is reliably determined. The pregnancy assays of this invention are preferably carried out using immunoassay devices which provide immediate results in the field.Type: ApplicationFiled: March 13, 2007Publication date: August 9, 2007Applicant: AspenBio Pharma, Inc.Inventors: J.W. Roth, Mark Colgin, Roger Hurst, Diane Newman, Cathy Landmann