Patents Assigned to Assembly Biosciences, Inc.
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Patent number: 11814376Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.Type: GrantFiled: January 4, 2021Date of Patent: November 14, 2023Assignees: Assembly Biosciences, Inc., Indiana University Research and Technology CorporationInventors: William W. Turner, Jr., Lee D. Arnold, Hans Maag, Leping Li, Mark G. Bures, Simon Nicolas Haydar, Samson Francis
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Publication number: 20230044112Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.Type: ApplicationFiled: January 4, 2021Publication date: February 9, 2023Applicants: Assembly Biosciences, Inc., INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATIONInventors: William W. Turner, JR., Lee D. Arnold, Hans Maag, Leping Li, Mark G. Bures, Simon Nicolas Haydar, Samson Francis
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Patent number: 11560370Abstract: The present disclosure provides, in part, 5-membered heteroaryl carboxamide compounds, and pharmaceutical compositions thereof, useful for disruption of HBV core protein assembly, and methods of treating Hepatitis B (HBV) infection.Type: GrantFiled: October 22, 2019Date of Patent: January 24, 2023Assignee: Assembly Biosciences, Inc.Inventors: Simon Nicolas Haydar, Leping Li, Mark G. Bures, Roopa Rai, Lynne Bannen, Michael Walker
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Publication number: 20230019129Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.Type: ApplicationFiled: January 21, 2021Publication date: January 19, 2023Applicants: Indiana University Research and Technology Corporation, Assembly Biosciences, Inc.Inventors: William W. Turner, JR., Lee Daniel Arnold, Hans Maag, Adam Zlotnick
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Patent number: 11078170Abstract: The present disclosure provides, in part, cyclic sulfamide compounds, and pharmaceutical compositions thereof, useful as modulators of Hepatitis B (HBV) core protein, and methods of treating Hepatitis B (HBV) infection.Type: GrantFiled: March 1, 2018Date of Patent: August 3, 2021Assignee: Assembly Biosciences, Inc.Inventors: William W. Turner, Jr., Leping Li, Simon Nicolas Haydar, Mark G. Bures, Roopa Rai, Samson Francis, Lee D. Arnold
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Patent number: 11040965Abstract: The present disclosure provides, in part, a process for preparing compounds (I) having allosteric effector properties against Hepatitis B virus Cp.Type: GrantFiled: March 13, 2018Date of Patent: June 22, 2021Assignee: Assembly Biosciences, Inc.Inventors: Leping Li, Lee D. Arnold, Sreenivasa Reddy Mundla
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Patent number: 11008315Abstract: The present disclosure provides, in part, a process for preparing compounds (I) having allosteric effector properties against Hepatitis B virus Cp.Type: GrantFiled: March 13, 2018Date of Patent: May 18, 2021Assignee: Assembly Biosciences, Inc.Inventors: Leping Li, Lee D. Arnold, Sreenivasa Reddy Mundla
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Patent number: 10987360Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp.Type: GrantFiled: September 14, 2017Date of Patent: April 27, 2021Assignee: Assembly Biosciences, Inc.Inventors: William W. Turner, Jr., Lee D. Arnold, Leping Li, Mark G. Bures, Simon Nicolas Haydar, Hans Maag, Lynne Bannen
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Patent number: 10968211Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.Type: GrantFiled: May 30, 2019Date of Patent: April 6, 2021Assignees: Assembly Biosciences, Inc., INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATIONInventors: William W. Turner, Jr., Lee D. Arnold, Hans Maag, Leping Li, Mark G. Bures, Simon Nicolas Haydar, Samson Francis
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Patent number: 10947224Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.Type: GrantFiled: April 27, 2018Date of Patent: March 16, 2021Assignees: Indiana University Research and Technology Corporation, Assembly Biosciences, Inc.Inventors: William W. Turner, Jr., Lee Daniel Arnold, Hans Maag, Adam Zlotnick
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Publication number: 20210060090Abstract: The disclosure relates generally to bacterial strains of the genus Christensenella, e.g., Christensenella sp. P152-H6d bacterial strains, and compositions comprising such bacterial strains. The disclosure further relates to methods of using such bacterial strains and compositions for preventing or treating a disorder, e.g., an inflammatory disorder, a gastrointestinal disorder, a metabolic disorder, and/or dysbiosis.Type: ApplicationFiled: August 28, 2020Publication date: March 4, 2021Applicants: Assembly Biosciences, Inc., Assembly Biosciences, Inc.Inventors: Peyman Akbari, Ali Akin, Rounak Feigelman, Wayne Herber, Jason Hudak, Jun Ma, Jackie Papkoff, Lauren Wong
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Patent number: 10766890Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.Type: GrantFiled: September 15, 2016Date of Patent: September 8, 2020Assignees: Assembly Biosciences, Inc., INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATIONInventors: William Turner, Hans Maag, Samson Francis
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Patent number: 10392379Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.Type: GrantFiled: September 15, 2016Date of Patent: August 27, 2019Assignees: Assembly Biosciences, Inc., Indiana University Research And Technology CorporationInventors: William Turner, Lee Daniel Arnold, Hans Maag, Mark Bures
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Patent number: 10377748Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.Type: GrantFiled: September 15, 2016Date of Patent: August 13, 2019Assignees: Assembly Biosciences, Inc., Indiana University Research And Technology CorporationInventors: William Turner, Lee Daniel Arnold, Hans Maag, Leping Li, Mark Bures, Simon Haydar, Samson Francis
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Patent number: 10273228Abstract: Novel assembly effector compounds having a therapeutic effect against hepatitis B viral (HBV) infection are disclosed. Assembly effector molecules described herein can lead to defective viral assembly and also may affect other viral activities associated with chronic HBV infection. Also disclosed is a process to synthesize disclosed compounds, method of treatment of HBV by administration of disclosed compounds, and use of these compounds in the manufacture of medicaments against HBV.Type: GrantFiled: April 15, 2016Date of Patent: April 30, 2019Assignees: Indiana University Research and Technology Corporation, Assembly Biosciences, Inc.Inventors: Lee Daniel Arnold, Hans Maag, William W. Turner, Jr.
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Patent number: 10183936Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.Type: GrantFiled: March 13, 2015Date of Patent: January 22, 2019Assignees: Indiana University Research and Technology Corporation, Assembly Biosciences, Inc.Inventors: William W. Turner, Jr., Lee Daniel Arnold, Hans Maag, Adam Zlotnick
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Publication number: 20180273520Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.Type: ApplicationFiled: September 15, 2016Publication date: September 27, 2018Applicants: Assembly Bioscience, Inc., INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATIONInventors: William Turner, Lee Daniel Arnold, Hans Maag, Mark Bures
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Publication number: 20180273521Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.Type: ApplicationFiled: April 27, 2018Publication date: September 27, 2018Applicants: Indiana University Research and Technology Corporationt, Assembly Biosciences, Inc.Inventors: William W. Turner, JR., Lee Daniel Arnold, Hans Maag, Adam Zlotnick
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Publication number: 20180258084Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.Type: ApplicationFiled: September 15, 2016Publication date: September 13, 2018Applicants: Assembly Biosciences, Inc., INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORA TIONInventors: William Turner, Lee Daniel Arnold, Hans Maag, Leping Li, Mark Bures, Simon Haydar, Samson Francis
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Publication number: 20180099952Abstract: Novel assembly effector compounds having a therapeutic effect against hepatitis B viral (HBV) infection are disclosed. Assembly effector molecules described herein can lead to defective viral assembly and also may affect other viral activities associated with chronic HBV infection. Also disclosed is a process to synthesize disclosed compounds, method of treatment of HBV by administration of disclosed compounds, and use of these compounds in the manufacture of medicaments against HBV.Type: ApplicationFiled: April 15, 2016Publication date: April 12, 2018Applicants: Indiana University Research and Technology Corporation, Assembly Biosciences, Inc.Inventors: Lee Daniel Arnold, Hans Maag, William W. Turner, Jr.
