Patents Assigned to Assia Chemical Industries Ltd.
  • Process for the preparation of Remimazolam and solid state forms of Remimazolam salts
    Patent number: 11820776
    Abstract: The present disclosure relates to novel processes for the preparation of short acting benzodiazepines as well as to novel intermediates in this process. More particularly the disclosure relates to processes and intermediates for preparation of Methyl 3-[(4S)-8-bromo-1-methyl-6-(pyridin-2-yl)-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propanoate, commonly known as Remimazolam. The present disclosure also relates to solid state forms of Remimazolam salts, processes for the preparation thereof, pharmaceutical formulations/compositions thereof, and methods of use thereof.
    Type: Grant
    Filed: May 24, 2021
    Date of Patent: November 21, 2023
    Assignee: ASSIA CHEMICAL INDUSTRIES LTD.
    Inventors: Dolitzky Ben-Zion, Mendelovici Marioara, Bodkhe Arjun Rajaram, Mane Ganesh Shivaji, Samala Rajamouli Srihari, Joshi Ashutosh Vijay, Parven Kumar Luthra, Amit Singh, Anantha Rajmohan Muthusamy
  • Solid state forms of ivosidenib
    Patent number: 11673880
    Abstract: Solid state forms of Ivosidenib, processes for preparation thereof, pharmaceutical compositions thereof, and uses thereof are disclosed.
    Type: Grant
    Filed: June 18, 2021
    Date of Patent: June 13, 2023
    Assignee: ASSIA CHEMICAL INDUSTRIES LTD.
    Inventors: Anantha Rajmohan Muthusamy, Amit Singh, Venkata Subbarao Yazali, Parven Kumar Luthra, Sanjay Lakhabhai Vasoya, Bhatu Tumba Patil, Amit Kumar Taneja, Naveen Chandra Srivastav, Rinku Singh, Vadivelan Rengasamy, Abhilash Tyagi
  • Solid state forms of rucaparib and of rucaparib salts
    Patent number: 11667646
    Abstract: Disclosed are solid state forms of Rucaparib and of Rucaparib salts, and pharmaceutical compositions thereof.
    Type: Grant
    Filed: December 15, 2020
    Date of Patent: June 6, 2023
    Assignee: ASSIA CHEMICAL INDUSTRIES LTD.
    Inventors: Dijana S. Samec, Jasna Dogan, Tomislav Biljan, Maja M. Skugor, Moris Mihovilovic, Tina Mundorfer, Nikolina Janton, Mihaela Tuksar, Sara M. Pipercic, Nea Baus Topic
  • Solid state forms of Omecamtiv mecarbil and Omecamtiv mecarbil diHCl
    Patent number: 11608318
    Abstract: The present disclosure relates to solid state forms of Omecamtiv mecarbil and Omecamtiv mecarbil diHCl, processes for preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: March 21, 2023
    Assignee: ASSIA CHEMICAL INDUSTRIES LTD.
    Inventors: Elvira Haimov, Doron Rudik, Maytal Piran
  • Crystalline polymorphs of Pracinostat and Pracinostat salts
    Patent number: 11465974
    Abstract: The present disclosure encompasses crystalline polymorphs of Pracinostat and of Pracinostat salts, and pharmaceutical compositions thereof.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: October 11, 2022
    Assignee: ASSIA CHEMICAL INDUSTRIES LTD.
    Inventors: Jenny Goldshtein, Maytal Piran, Doron Rudik, Rotem Sella-Erez, Sharona Alfasie Shachan-Tov, Ofir Shaul
  • Crystalline polymorphs of Rivoceranib and Rivoceranib mesylate
    Patent number: 11434202
    Abstract: The present disclosure encompasses crystalline polymorphs of Rivoceranib and Rivoceranib mesylate (Apatinib mesylate), processes for preparation thereof, and pharmaceutical compositions thereof.
    Type: Grant
    Filed: September 4, 2019
    Date of Patent: September 6, 2022
    Assignee: ASSIA CHEMICAL INDUSTRIES LTD.
    Inventors: Anantha Rajmohan Muthusamy, Sundara Lakshmi Kanniah, Elluru Subbireddy
  • Solid state form of Valbenazine
    Patent number: 11384077
    Abstract: Salts and solid state forms of Valbenazine, including Valbenazine ditosylate, processes for preparation thereof, pharmaceutical compositions thereof, and uses thereof are disclosed.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: July 12, 2022
    Assignee: ASSIA CHEMICAL INDUSTRIES LTD.
    Inventors: Khaled Haj Ali, Marina Yarovoy, Jonathan Enav
  • Crystalline form E1 of larotrectinib ethanesulfonate
    Patent number: 11339164
    Abstract: Salts and solid state forms of Larotrectinib, processes for preparation thereof, pharmaceutical compositions thereof, and uses thereof are disclosed.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: May 24, 2022
    Assignee: ASSIA CHEMICAL INDUSTRIES LTD.
    Inventors: Sharona Shachan-Tov, Doron Rudik, Oshrat Frenkel, Rotem Sella-Erez, Maytal Piran, Ido Fuchs
  • Solid state forms of valbenazine
    Patent number: 11242341
    Abstract: Solid state forms of Valbenazine, Valbenazine salts, processes for preparation thereof and pharmaceutical compositions thereof are disclosed. Processes for the preparation of Valbenazine and intermediates in the preparation thereof are further described.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: February 8, 2022
    Assignee: ASSIA CHEMICAL INDUSTRIES LTD.
    Inventors: Ariel Mittelman, Sharona Shachan-Tov, Abed Masarwa, Rotem Sella-Erez, Jonathan Enav, Motti Erlich, Victoria Machtey, Maytal Piran, Marina Yarovoy, Sagit Azran, Einat Kisin-Finfer, Tamar Nidam
  • Solid state forms of eltrombopag choline
    Patent number: 11072586
    Abstract: Solid state forms of Eltrombopag choline, processes for preparation thereof and pharmaceutical compositions thereof are disclosed.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: July 27, 2021
    Assignee: ASSIA CHEMICAL INDUSTRIES LTD.
    Inventors: Sharma Vijay Hariprasad, Nasir Ali Shafakat Ali, Joshi Ashutosh Vijay, Parven Kumar Luthra, Anantha Rajmohan Muthusamy, Amit Singh, Rajesh Sadanand Bate, Sadanand Hardeo Maurya
  • Solid state forms of Ivosidenib
    Patent number: 11066390
    Abstract: Solid state forms of Ivosidenib, processes for preparation thereof, pharmaceutical compositions thereof, and uses thereof are disclosed.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: July 20, 2021
    Assignee: ASSIA CHEMICAL INDUSTRIES LTD.
    Inventors: Anantha Rajmohan Muthusamy, Amit Singh, Venkata Subbarao Yazali, Parven Kumar Luthra, Sanjay Lakhabhai Vasoya, Bhatu Tumba Patil, Amit Kumar Taneja, Naveen Chandra Srivastav, Rinku Singh, Vadivelan Rengasamy, Abhilash Tyagi
  • Solid state forms of Venetoclax and processes for preparation of Venetoclax
    Patent number: 11001582
    Abstract: Processes for the preparation of Venetoclax and Venetoclax produced by the processes are disclosed.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: May 11, 2021
    Assignee: ASSIA CHEMICAL INDUSTRIES LTD.
    Inventors: Zsuzsa Potarine Juhasz, Szabolcs Struba, Csilla Nemethne Racz, Zoltan Gabor Toth, Andrea Szilagyi, Renata Kerti-Ferenczi, Sandor Janos Molnar, Nora Pasztor-Debreczeni, Janos Hajko
  • SALTS AND SOLID STATE FORMS OF LAROTRECTINIB
    Publication number: 20200255435
    Abstract: Salts and solid state forms of Larotrectinib, processes for preparation thereof, pharmaceutical compositions thereof, and uses thereof are disclosed.
    Type: Application
    Filed: October 31, 2018
    Publication date: August 13, 2020
    Applicants: ASSIA CHEMICAL INDUSTRIES LTD., ASSIA CHEMICAL INDUSTRIES LTD.
    Inventors: Sharona Shachan-Tov, Doron Rudik, Oshrat Frenkel, Rotem Sella-Erez, Maytal Piran, Ido Fuchs
  • Solid state forms of netarsudil mesylate
    Patent number: 10584100
    Abstract: Disclosed are solid state forms of Netarsudil mesylate, processes for preparation thereof, uses thereof, and pharmaceutical compositions thereof.
    Type: Grant
    Filed: September 4, 2019
    Date of Patent: March 10, 2020
    Assignee: ASSIA CHEMICAL INDUSTRIES LTD.
    Inventors: Alexander Mainfeld, Sharona Shachan-tov, Ariel Mittelman, Rotem Sella-Erez, Yifat Ronen, Tamar Nidam
  • Solid state forms of netarsudil mesylate
    Patent number: 10442770
    Abstract: Disclosed are solid state forms of Netarsudil mesylate, processes for preparation thereof, uses thereof, and pharmaceutical compositions thereof.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: October 15, 2019
    Assignee: ASSIA CHEMICAL INDUSTRIES LTD.
    Inventors: Alexander Mainfeld, Sharona Shachan-tov, Ariel Mittelman, Rotem Sella-Erez, Yifat Ronen, Tamar Nidam
  • Solid state forms of vilazodone and vilazodone hydrochloride
    Patent number: 9505744
    Abstract: The present invention provides solid state forms of Vilazodone and Vilazodone hydrochloride, processes for preparing these solid state forms, and pharmaceutical compositions comprising one or more of these solid state forms.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: November 29, 2016
    Assignee: Assia Chemical Industries LTD.
    Inventors: Edislav Leksic, Dubravka Pavlicic, Dijana Skalec Samec, Jasna Dogan
  • COBICISTAT DICHLOHYDRATE SALT
    Publication number: 20160200716
    Abstract: The present invention encompasses Cobicistat dihydrochloride salt, and pharmaceutical compositions thereof.
    Type: Application
    Filed: December 23, 2013
    Publication date: July 14, 2016
    Applicant: Assia Chemical Industries Ltd.
    Inventors: Jacob RENDELL, Ariel MITTELMAN, Sofia GOROHOVSKY, Motti ERLICH
  • Saxagliptin intermediates, saxagliptin polymorphs, and processes for preparation thereof
    Patent number: 8501960
    Abstract: The invention provides Saxagliptin Schiff bases, polymorphs of Saxagliptin and (1S,3S,5S)-2-[(2S)-2-propan-2-ylideneamino-2-(3-hydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile, processes for preparing Saxagliptin hydrates, and pharmaceutical compositions thereof.
    Type: Grant
    Filed: May 5, 2011
    Date of Patent: August 6, 2013
    Assignee: Assia Chemical Industries Ltd.
    Inventors: Marina Ratkaj, Tomislav Biljan, Marina Marinkovic