Abstract: A method for developing a prediction device for predicting a phenotype of a person from imaging data of the person is provided. The method includes determining imaging descriptors, the determining imaging descriptors including acquiring multidimensional images of people with an imaging apparatus and extracting multidimensional image elements from the acquired multidimensional images to serve as descriptors The method also includes classifying the predetermined descriptors on the basis of the capability thereof to predict the phenotype, selecting, from among the classified descriptors, a relevant number of the best-classified descriptors that is sufficient to predict the phenotype and constructing the prediction device from the selected descriptors.

Abstract: An electronic polarimetric imaging system for a colposcopy device designed for in vivo observation of a cervix, wherein the colposcopy device includes a light source for illuminating the observable cervix and at least visual elements for monitoring an image of the cervix, the illumination optical path towards the cervix and the image optical path coming back from the cervix being separated from one another over at least one portion of the paths thereof. The system includes a polarimetric adapter housing which is removable into the separated portion of the illumination and image optical paths, the polarimetric adapter housing including a polarisation state generator (PSG) on the illumination optical path and a polarisation analyser (PSA) on the image optical path, wherein the polarisation state generator (PSG) and the polarisation analyser (PSA) are controllable. Several levels of polarimetric characterisation are possible. An adaptor housing is also disclosed.

Abstract: A device for processing a cytological or histological preparation includes: a carousel, including at least one space for receiving a slide for receiving a cytological or histological preparation, the carousel being rotatably mounted about an axis of rotation; a nebulizing head that passes above the carousel, including the piezoelectric element and a space for the reagent such that the nebulising head expels at least one drop of reagent as a result of the deformation of the piezoelectric element.

Abstract: The invention relates to a phonation assistance device for a tracheotomy patient, including: an exhalation circuit connected to a tracheotomy cannula inserted in the trachea of the patient, the exhalation circuit including an outlet opening for the passage of the air exhaled by the patient; and a valve for opening/closing the outlet opening for normally assuming, when the patient inhales, a position for closing the outlet opening and, when the patient exhales, a position for closing the outlet opening. It also includes means for the positive priority control of the valve for selectively moving the valve into the closed position when the patient exhales.

Abstract: The invention concerns the use of at least one: a) a GILZ protein, a functional fragment of at least 5 consecutive amino acids of said protein, a GILZ modulator, or a recombinant vector expressing same, isolated or expressed in modified dendritic cells, and b) an antigen of interest and/or a molecule allowing targeting and/or passage of the plasmic membrane of dendritic cells, to prepare a medicine for preventing and/or treating autoimmune, inflammatory diseases, allergies, graft rejection and graft-versus-host disease, cancers and pathogenic micro-organism infections.

Abstract: The invention relates to a method for diagnosing thrombophilia in a subject suffering from HIV or from a systemic auto-immune disease, said method comprising determining in a blood sample obtained from said subject the level of free Protein S having Activated Protein C (APC) cofactor activity and the level of total Protein S.

Abstract: The invention relates to an immunological method for detecting an extra renal active infection by JC virus in a patient candidate for a treatment with an immunosuppressive treatment or during the course of this treatment.

Abstract: A system and method for processing signals for the real-time detection of a functional cyclic activity, include: elements for simultaneously receiving signals acquired by a sensor array having at least two sensors; elements for recording and preprocessing the acquired signals during a plurality of consecutive cycles; elements for identifying event combinations from the recordings of the acquired signals, enabling a calibration to be carried out, including: elements for identifying a plurality of events in the acquired signals, each signal including an identified event; elements for defining a model of the functional activity, consisting of a time order of the events and the mean delays between the events, and elements for defining a detection time window from the functional activity model.

Abstract: The present invention relates to interfering RNAs, in particular miRNAs, capable of specifically blocking the replication of a strain of the HIV virus that is resistant to an antiretroviral compound, and use thereof for treating infections by this type of virus.

Abstract: The invention concerns methods of screening for a hepatic syndrome occurring in the young adult and associating cholesterol biliary microlithiasis, intrahepatic cholestasis and several mutations of the MDR3 gene. The invention is also directed to methods for the treatment of said syndrome. The hepatic syndrome screening methods comprise detecting, from a nucleic acid sample extracted from peripheral blood mononucleate cells, heterozygous mutations of the MDR3 gene and/or homozygous mutations of the MDR3 gene that do not eliminate the expression of the protein expressed by the MDR3 gene, which has phosphatidylcholine carrier activity, in adult subjects associating cholesterol biliary microlithiasis and intrahepatic cholestasis.

Abstract: The present invention relates to the use of a composition including of at least a mutated antithrombin having an anticoagulant activity substantially reduced with respect to the anticoagulant activity of the non mutated antithrombin, or having no anticoagulant activity, for the preparation of a drug intended for the prevention or the treatment of pathologies associated with cellular injury, such as infection, inflammation or hypoxic injury.

Abstract: The invention relates to a method for the in vitro detection of vasculitis or the risk of developing vasculitis, including determining the presence and/or the amount of anti-endothelial cell antibodies (AECA) or anti-vascular smooth muscle cell (VSMC) antibodies in a biological sample from a patient.

Abstract: The invention relates to a method for identifying a strain isolated from a clinical sample, at the species and/or subspecies level, using MALDI-TOF-MS analysis comprising a step of classifying the germ in a group before performing the MALDI-TOF-MS analysis.

Abstract: The invention concerns a method for assaying soluble fibrin in a sample, in which said sample is brought into the presence of a plasminogen activator with a high specificity for soluble fibrin (PA-Fb sp) and the soluble fibrin count in the sample is measured by measuring the difference between the count of fibrin degradation products obtained after degrading soluble fibrin with PA-Fb sp and the base count of fibrin degradation products determined before bringing the sample into the presence of PA-Fb sp.

Abstract: Oral drug delivery formulations which specifically administer antibacterial agents to the ileum, caecum, and/or the colon, without significant administration elsewhere in the gastrointestinal tract, are disclosed. The formulations include, as actives, a combination of a macrolide or aminoglysoside, or quinolone antibacterial and an anti-Gram-negative lipopeptide (polymyxin) antibacterial agent or other peptide antibacterials effective against Gram-negative bacteria. The formulations can be used to treat infections or unwanted colonization in the colon, and to provide effective decontamination of the colonic flora from unwanted or potentially pathogenic bacteria.

Abstract: The invention relates to the use of gingival fibroblasts for obtaining a cellular composition for treating arterial-remodelling pathology, for example an aneurysm, post-cryoplasty stenosis and restenosis, an aortic dissection or atherosclerosis.

Abstract: The present invention concerns new methods for treating cancer by using TYRO3 inhibitors and methods for identifying new molecules of interest for treating cancer.

Abstract: The present invention relates to a method for producing platelets from mature megakaryocytes. More particularly, the invention relates to an ex vivo method for producing platelets, from mature megakaryocytes, said method comprising a step of subjecting a suspension of mature megakaryocytes to a flow having a minimal shear rate of 600 s?1 on a solid phase coated with Von Willebrand factor.

Abstract: The present invention discloses a method for increasing the pool of Ngn3+ endocrine progenitor cells obtained from stem cells, by contacting said stem cells with a SUR1/Kir6.2 channel inhibitor. The invention also relates to a method for increasing the mass of pancreatic endocrine cells, in particular of ? cells. The invention further concerns a method for treating diabetes.

Abstract: This system is characterized in that includes: means (20) for acquiring information relating to the respiratory state of the patient (1) over a breathing cycle, means (21) for acquiring information relating to the operating state of the assistance device (2) over a mechanical cycle, means for filtering (22) and for processing (23) this information in order to detect and localize the changes in states of the patient over a breathing cycle and of the device over a mechanical cycle, means (24) for calculating a piece of information on desynchronization between the patient and the device from these changes in states, and means (25) forming a man/machine interface for returning this piece of desynchronization information to an operator.