Patents Assigned to Assitance Publique Hopitaux
  • Cardiac device
    Patent number: 11957437
    Abstract: A cardiac device comprises a memory arranged for receiving haemodynamic data, and a computer arranged for applying a cardiovascular model comprising a cardiac model and an arterial and venous blood circulation model using the data received in the memory, and for extracting therefrom at least one cardiac activity indicator (CI).
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: April 16, 2024
    Assignees: Inria Institut National De Recherche En Informatique Et En Automatique, Assitance Publique Hopitaux
    Inventors: Radomir Chabiniok, Dominique Chapelle, Arthur Le Gall, Philippe Moireau, Fabrice Vallee
  • Methods for detecting or quantifying CTP and CTP synthase activity
    Patent number: 10731197
    Abstract: The present invention relates to a method for detecting or quantifying CTP in a cell sample comprising at least two nucleotide triphosphates by cationic ion pairing chromatography coupled to mass spectrometry, to a method for detecting or quantifying CTP synthase activity based on the method for detecting or quantifying CTP, and to their use in methods for screening potential immunosuppressive or anti-cancer compounds and in methods for determining the appropriate dose of an immunosuppressive or anti-cancer compound inhibiting CTP synthase activity for a treated subject.
    Type: Grant
    Filed: October 10, 2016
    Date of Patent: August 4, 2020
    Assignees: Assitance Publique-Hopitaux de Paris, Imagine Institut Des Maladies Genetiques Necker Enfants Malades, Universite Paris Descartes, Institut National de la Sante et de la Recherche Medicale (INSERM), Centre National de la Recherche Scientifique (CNRS)
    Inventors: Sylvia Sanquer, Anne-Claire Boschat, Sylvain Latour, Emmanuel Martin, Robert Barouki
  • Antagonist of the fibroblast growth factor receptor 3 (FGFR3) for use in the treatment or the prevention of skeletal disorders linked with abnormal activation of FGFR3
    Patent number: 9931341
    Abstract: The present invention relates to the treatment or prevention of skeletal disorders, in particular skeletal diseases, developed by patients that display abnormal increased activation of the fibroblast growth factor receptor 3 (FGFR3), in particular by expression of a constitutively activated mutant of FGFR3.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: April 3, 2018
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE PARIS DESCARTES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ASSITANCE PUBLIQUE HOPITAUX DE PARIS, UNIVERSITE PARIS DIDEROT-PARIS 7, IMAGINE
    Inventors: Laurence Legeai-Mallet, Arnold Munnich, Patricia Busca, Florent Barbault
  • Pharmaceutical compositions comprising a polypeptide comprising at least one CXXC motif and heterologous antigens and uses thereof
    Patent number: 9801927
    Abstract: The invention relates to pharmaceutical compositions using a polypeptide comprising at least one CXXC motif, such as Giardia parasite's variable surface proteins (VSP) or a fragment thereof to raise by oral or mucosal vaccination an immune response against a heterologous selected antigen, such as tumor antigen, microbial antigen or other antigen.
    Type: Grant
    Filed: March 29, 2011
    Date of Patent: October 31, 2017
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), ASSITANCE PUBLIQUE HOPITAUX DE PARIS, CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET), UNIVERSIDAD CATOLICA DE CORCOBA (UCC)
    Inventors: David Klatzmann, Eliane Piaggio, Hugo Daniel Luján
  • COMPOUND-CARRIER SYSTEMS FOR ASSAYS IN NEMATODES
    Publication number: 20160047796
    Abstract: The present invention relates to methods for increasing absorption of compounds of interest by nematode worms through the design of carrier systems containing said compound of interest and expressing chemoattractive tags at their surface.
    Type: Application
    Filed: March 7, 2014
    Publication date: February 18, 2016
    Applicant: Assitance Publique - Hopitaux de Paris
    Inventor: Philippe Manivet
  • Antibodies binding to adrenomedullin receptors and uses thereof as drugs
    Patent number: 9028818
    Abstract: The invention relates to antibodies binding to the proteins forming adrenomedullin receptors, and to the uses thereof as a drug.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: May 12, 2015
    Assignees: Universite d'Aix-Marseille, Assitance Publique Hôpitaux de Marseille
    Inventors: L'Houcine Ouafik, Kamel Mabrouk, Itidal Kaafarany, Pierre-Marie Martin
  • Non-M, non-O HIV-1 strains, fragments and uses
    Patent number: 7534877
    Abstract: Retroviral strains of the non-M, non-O HIV-1 group, in particular a strain designated YBE30, its fragments and also its uses as a diagnostic reagent and as an immunogenic agent. The HIV-1 viruses which differ both from the M group and the O group exhibit the following characteristics: little or no serological reactivity with regard to the proteins of the M and O groups and strong serological reactivity with regard to the proteins which are derived from the strain YBF30 according to the invention or the strain CPZGAB SIV; absence of genomic amplification when using primers from the env and gag regions of the M and O HIV-1 groups; genomic amplification in the presence of primers which are derived from the YBF30 strain according to the invention; and homology of the products of the envelope gene which is greater than 70% with regard to the YBF30 strain.
    Type: Grant
    Filed: September 15, 2005
    Date of Patent: May 19, 2009
    Assignees: Institute National de la Sante et de la Recherche Medicale-Inserm, Assitance Publique-Hopitaux de Paris, Institut Pasteur
    Inventors: Phillippe Mauclere, Ibtissam Loussert-Ajaka, Francois Simon, Sentob Saragosti, Francoise Barre-Sinoussi