Abstract: A pharmaceutical preparation containing a complex consisting of type B botulinum neurotoxin and stabilizing proteins, both derived from C. botulinum, admixed with a pharmaceutically acceptable excipient is provided. The preparation is effective for inducing titratable, local, selective muscle denervation in a patient suffering from a disorder characterized by involuntary muscle spasm or contraction.

Abstract: The activity of chemodenervating agents can be ascertained by injecting locally a known quantity of the agent and determining the extent of inhibition of acetylcholine release about the locus resulting therefrom. Inhibition of acetylcholine release is indicative of denervation in a muscle, therefore the extent of inhibition of acetylcholine release is coextensive with the zone of denervation induced by the quantity of the agent.

Abstract: This invention relates to a method for controlled administration of chemodernervating agents such as botulinum toxin-derived pharmaceutical, useful in attenuating neural stimulation and spasmodic activity of muscle. The method involves administration of novel dosage forms based upon the standardization of denervating pharmaceuticals. The invention also relates to novel methods of administrating chemodernervating agents in a controlled and reproducible manner so as to confine their effects to a given region of muscle mass while minimizing in adjacent muscle tissue.

Abstract: This invention relates to a method for controlled administration of chemodernervating agents such as botulinum toxin-derived pharmaceutical, useful in attenuating neural stimulation and spasmotic activity of muscle. The method involves administration of novel dosage forms based upon the standardization of denervating pharmaceuticals. The invention also relates to novel methods of administering chemodernervating agents in a controlled and reproducible manner so as to confine their effects to a given region of muscle mass while minimizing paresis in adjacent muscle tissue.