Patents Assigned to Associated Universities, Inc.
  • Patent number: 4966785
    Abstract: A method for coating interior capillary column surfaces, or packing material of a packed column, used for gas chromatography, with a stationary polymer phase that is cross-linked by exposing it to a low-temperature plasma that is uniformly distributed over the column or packing material for a predetermined period of time to effect the desired degree of cross-linking of the coating.
    Type: Grant
    Filed: July 3, 1989
    Date of Patent: October 30, 1990
    Assignee: Associated Universities, Inc.
    Inventor: Stephen R. Springston
  • Patent number: 4960707
    Abstract: Chromosomal DNA cassettes containing genes encoding either the DpnI or DpnII restriction endonucleases from Streptococcus pneumoniae are cloned into a streptococcal vector, pLS101. Large amounts of the restriction enzymes are produced by cells containing the multicopy plasmids, pLS202 and pLS207, and their derivatives pLS201, pLS211, pLS217, pLS251 and pLS252.
    Type: Grant
    Filed: August 17, 1987
    Date of Patent: October 2, 1990
    Assignee: Associated Universities, Inc.
    Inventor: Sanford A. Lacks
  • Patent number: 4952496
    Abstract: This application describes a means to clone a functional gene for bacteriophage T7 RNA polymerase. Active T7 RNA polymerase is produced from the cloned gene, and a plasmid has been constructed that can produce the active enzyme in large amounts. T7 RNA polymerase transcribes DNA very efficiently and is highly selective for a relatively long promoter sequence. This enzyme is useful for synthesizing large amounts of RNA in vivo or in vitro, and is capable of producing a single RNA selectively from a complex mixture of DNAs. The procedure used to obtain a clone of the T7 RNA polymerase gene can be applied to other T7-like phages to obtain clones that produce RNA polymerases having different promoter specificities, different bacterial hosts, or other desirable properties. T7 RNA polymerase is also used in a system for selective, high-level synthesis of RNAs and proteins in suitable host cells.
    Type: Grant
    Filed: December 29, 1986
    Date of Patent: August 28, 1990
    Assignee: Associated Universities, Inc.
    Inventors: F. William Studier, Parichehre Davanloo, Alan H. Rosenberg, Barbara A. Moffatt, John J. Dunn
  • Patent number: 4942303
    Abstract: A computer controlled fluorometer device and method of operating same, said device being made to include a pump flash source and a probe flash source and one or more sample chambers in combination with a light condenser lens system and associated filters and reflectors and collimators, as well as signal conditioning and monitoring means and a programmable computer means and a software programmable source of background irradiance that is operable according to the method of the invention to rapidly, efficiently and accurately measure photosynthetic activity by precisely monitoring and recording changes in fluorescence yield produced by a controlled series of predetermined cycles of probe and pump flashes from the respective probe and pump sources that are controlled by the computer means.
    Type: Grant
    Filed: January 31, 1989
    Date of Patent: July 17, 1990
    Assignee: Associated Universities, Inc.
    Inventors: Zbigniew Kolber, Paul Falkowski
  • Patent number: 4936384
    Abstract: Geothermal wells with lost circulation problems are treated with a lightweight, high temperature (i.e. 350.degree. C.) cement slurry which incorporates pressure resistant hollow microspheres into the slurry wherein the spheres have been pretreated with an alkali compound such as Ca(OH).sub.2 for up to 20 hours and at 100.degree.-300.degree. C. Preferably, the alkali solution is a saturated aqueous solution and the treatment is for 10 hours.
    Type: Grant
    Filed: December 13, 1988
    Date of Patent: June 26, 1990
    Assignee: Associated Universities, Inc.
    Inventor: Toshifumi Sugama
  • Patent number: 4935395
    Abstract: There is disclosed synthesis of CH.sub.3 OH from carbon monoxide and hydrogen using an extremely active homogeneous catalyst for methanol synthesis directly from synthesis gas. The catalyst operates preferably between 100.degree.-150.degree. C. and preferably at 100-150 psia synthesis gas to produce methanol. Use can be made of syngas mixtures which contain considerable quantities of other gases, such as nitrogen, methane or excess hydrogen. The catalyst is composed of two components: (a) a transition metal carbonyl complex and (b) an alkoxide component. In the simplest formulation, component (a) is a complex of nickel tetracarbonyl and component (b) is methoxide (CH.sub.3 O.sup.13 ), both being dissolved in a methanol solvent system. The presence of a co-solvent such as p-dioxane, THF, polyalcohols, ethers, hydrocarbons, and crown ethers accelerates the methanol synthesis reaction.
    Type: Grant
    Filed: January 7, 1988
    Date of Patent: June 19, 1990
    Assignee: Associated Universities, Inc.
    Inventors: Devinder Mahajan, Richard S. Sapienza, William A. Slegeir, Thomas E. O'Hare
  • Patent number: 4927462
    Abstract: The interfacial bond characteristics between carbon fiber and a cement matrix, in high temperature fiber-reinforced cementitious composite systems, can be improved by the oxidative treatment of the fiber surfaces. Compositions and the process for producing the compositions are disclosed.
    Type: Grant
    Filed: December 23, 1988
    Date of Patent: May 22, 1990
    Assignee: Associated Universities, Inc.
    Inventor: Toshifumi Sugama
  • Patent number: 4889718
    Abstract: Hydrophylic polyacids, such as macromolecules of polyitaconic acid and polyacrylic acid, where such macromolecules have molecular weights >50,000 as primers between a polymeric top coating, such as polyurethane, and an oxidized aluminum or aluminum alloy. A near monolayer of primer is used in polymeric adhesive/oxidized aluminum adhered joint systems in 0.05% primer concentration to give superior results in standard peel tests.
    Type: Grant
    Filed: May 2, 1988
    Date of Patent: December 26, 1989
    Assignee: Associated Universities, Inc.
    Inventor: Toshifumi Sugama
  • Patent number: 4882243
    Abstract: The present invention relates to ion-conducting solvent-free polymeric systems characterized as being cationic single ion conductors. The solvent-free polymer electrolytes comprise a flexible polymer backbone to which is attached a metal salt, such as a lithium, sodium or potassium salt, of a sterically hindered phenol. The solid polymer electrolyte may be prepared either by (1) attaching the hindered phenol directly to a flexible polymeric backbone, followed by neutralization of the phenolic OH's or (2) reacting the hindered phenol with a polymer precursor which is then polymerized to form a flexible polymer having phenolic OH's which are subsequently neutralized. Preferably the hindered phenol-modified polymeric backbone contains a polyether segment. The ionic conductivity of these solvent-free polymer electrolytes has been measured to be in the range of 10.sup.-4 to 10.sup.-7 S cm.sup.-1 at room temperature.
    Type: Grant
    Filed: November 22, 1988
    Date of Patent: November 21, 1989
    Assignees: Polytechnic University, Associated Universities, Inc.
    Inventors: Terje A. Skotheim, Yoshiyuki Okamoto, Hung S. Lee
  • Patent number: 4871395
    Abstract: Cement slurries are disclosed which are suitable for use in geothermal wells since they can withstand high temperatures and high pressures. The formulation consists of cement, silica flour, water, a retarder, a foaming agent, a foam stabilizer, and a reinforcing agent. A process for producing these cements is also disclosed.
    Type: Grant
    Filed: September 17, 1987
    Date of Patent: October 3, 1989
    Assignee: Associated Universities, Inc.
    Inventor: Toshifumi Sugama
  • Patent number: 4833394
    Abstract: An apparatus for producing a signal that is representative of the profile of an ion beam and compensates for the system noise of the ion beam profile scanner includes an ion beam profile scanner which produces a beam profile signal that is proportional to the profile of the ion beam and that has system noise from the scanner. A reference signal is produced which has a frequency proportional to the scan frequency of the beam profile signal, and at least one harmonic of the reference signal is also produced. The reference signal and at least one harmonic of the reference signal are individually adjusted in phase and amplitude to match the system noise in the beam profile signal, and the two adjusted signals are subtracted from the beam profile signal in a summation circuit. The resulting signal is representative of the beam profile and has reduced noise as compared to the beam profile signal.
    Type: Grant
    Filed: September 1, 1988
    Date of Patent: May 23, 1989
    Assignee: Oak Ridge Associated Universities, Inc.
    Inventor: Michael L. Simpson
  • Patent number: 4822422
    Abstract: Geothermal wells with lost circulation problems are treated with a lightweight, high temperature (i.e. 350.degree. C.) cement slurry which incorporates pressure resistant hollow microspheres into the slurry wherein the spheres have been pretreated with an alkali compound such as Ca(OH).sub.2 for up to 20 hours and at 100.degree.-300.degree. C. Preferably, the alkali solution is a saturated aqueous solution and the treatment is for 10 hours.
    Type: Grant
    Filed: October 9, 1987
    Date of Patent: April 18, 1989
    Assignee: Associated Universities, Inc.
    Inventor: Toshifumi Sugama
  • Patent number: 4756904
    Abstract: A method of imaging the heart to provide a distinct image using positron emission tomography comprises administering copper-64 citrate and a compatible carrier.
    Type: Grant
    Filed: June 5, 1986
    Date of Patent: July 12, 1988
    Assignee: Oak Ridge Associated Universities, Inc.
    Inventor: James E. Crook
  • Patent number: 4755375
    Abstract: Disclosed herein are a method and kit for the preparation of .sup.99m Tc labeled red blood cells using whole blood in a closed sterile system containing stannous tin in a form such that it will enter the red blood cells and be available therein for the reduction of technetium.
    Type: Grant
    Filed: April 17, 1986
    Date of Patent: July 5, 1988
    Assignee: Associated Universities, Inc.
    Inventors: Suresh C. Srivastava, John W. Babich, Rita Straub, Powell Richards
  • Patent number: 4025878
    Abstract: A waveguide coupler for coupling energy between two different waveguides through a coupling of their magnetic fields. Each of the waveguides, between which coupling is to take place, is capable of supporting electromagnetic waves having different phase velocities. The first waveguide has a circular cross section and is shaped and dimensioned so as to support a TE.sub.mn or a TM.sub.mn mode of wave propagation. A further length of waveguide, such as one having a rectangular cross section, is capable of supporting a different order mode of wave propagation. The wave supported within the rectangular waveguide has a higher phase velocity than that supported within the circular waveguide. The rectangular waveguide is helically wrapped around the outer surface of the circular waveguide in such a manner that the longitudinal fields of the electromagnetic waves are coupled between the two waveguides through a plurality of apertures which are provided within both waveguides along their contacting helical path.
    Type: Grant
    Filed: March 8, 1976
    Date of Patent: May 24, 1977
    Assignee: Associated Universities, Inc.
    Inventor: Clayton Read Predmore