Abstract: The invention relates to a plasma derived immunoglobulin G concentrate and to the process for producing said concentrate. The process comprises a series of chromatographic separations but no ethanol precipitation. The process also includes a viral inactivation treatment. The invention relates to the immunoglobulin G concentrate obtained by said process which is of therapeutic quality suitable for any use especially for intraveinous injection.

Abstract: The invention relates to 2 human monoclonal antibodies of sub-classes IgG1 and IgG3, against the Rhesus D antigen and to a pharmaceutical composition containing a mixture of the said antibodies, more particularly intended for the prophylaxis of the haemolytic disease of the newborn. The invention also relates to the heterohybridoma cell lines that produce these antibodies, which are filed with the "Deutsche Sammlung von Mikroorganismen und Zellkulturen" under accession numbers DSM AC 2039 and DSM AC 2040.

Abstract: A process is disclosed for preparing human inter-alpha-trypsin inhibitor (ITI) from human plasma which comprises two steps of anion exchange chromatography followed by a step of affinity chromatography on immobilized heparin. The process also includes a viral inactivation treatment. The quality of the ITI concentrate obtained is suitable for therapeutic use.

Abstract: Disclosed is a process for preparing a C1-esterase inhibitor concentrate, of human plasma origin, comprising 2 separations by chromatography on ion exchanger gels of tentacular type.

Abstract: The chassis (1) of the machine supports a fixed supply table and three successive transfer conveyor belts (3, 14, 19) capable of routing the blood bags towards discharge chutes mounted at the other end. Stations (4, 20) for reading the codes and labels on the blood bags are disposed respectively above the first belt (3) and the third belt (19) on either side of two label appending robots (8). The intermediate belt (14) comprises a weighing unit (16). Application to the labelling of blood bags prior to transfusion.

Abstract: Machine for continuously cutting open bags of deep frozen plasma including a feed table, a cutting area adjacent the feed table and a collection area. The cutting area has a cutting nozzle for cutting the deep frozen bags of plasma on a longitudinal median portion of the bag. The cutting nozzle emits a cutting jet of water under very high pressure. A conveyor made up of two endless belts continuously travels the deep frozen bags of plasma one after another under the cutting nozzle. The conveyor includes the two side-by-side endless belts mounted around horizontal rollers at opposite ends of a chassis. The belts have a small gap between them which is located vertically in relation to the cutting nozzle.

Abstract: Process for preparing a human thrombin concentrate from the PPSB fraction of plasma that does not involve any addition of factors of animal origin to induce activation of the prothrombin to produce thrombin, and which includes a viral inactivation step using solvent-detergent and purification by cation exchange chromatography. The choice of a protective medium ensures the high specific activity of the final product. The thrombin concentrate obtained using this process is intended for therapeutic use, either alone, to serve as a local hemostatic agent, or in combination with a fibrinogen concentrate to form biological glue.

Abstract: The invention relates to a human Factor XI concentrate having high specific activity prepared using a process comprising a filtration-adsorption step and a single step of chromatography on cation exchange resin.The concentrate obtained is perfectly suitable for therapeutic use in replacement therapy in cases of Factor XI deficiency.