Abstract: The invention relates to the use of structural analogues of distamycin having the general formula (I), (II), (III), (IV) or (V) or their pharmaceutically acceptable salts, for the preparation of a medicament for the therapeutic treatment of ?-thalassaemia.
Type:
Grant
Filed:
July 1, 2002
Date of Patent:
July 8, 2008
Assignees:
Universita' Degli Studi Di Ferrara, Associazione Veneta per La Lotta Alla Talassemia, Associazione per La Lotta Alla Talassemia Di Ferrara
Inventors:
Pier Giovanni Baraldi, Nicoletta Bianchi, Giordana Feriotto, Roberto Gambari, Carlo Mischiati, Romeo Romagnoli
Abstract: The invention refers to a synthetic double-stranded oligonucleotide having a length comprised between 10 and 50 bases and a nucleic acid sequence selected from the group consisting of: (a) sequences corresponding to a selected portion of the promoter of human ?-globin gene; and (b) sequences corresponding to a selected portion of the human genomic region comprised between the ?-globin gene and the ??-cluster, for use as an inducer of erythroid differentiation.
Type:
Grant
Filed:
March 13, 2001
Date of Patent:
August 28, 2007
Assignees:
Universita' Degli Studi Di Ferrara, Associazione Veneta Per La Lotta Alla Talassemia, Associazione Per La Lotta Alla Talassemia Di Ferrara, Chiesi Farmaceutici S.p.A.
Inventors:
Nicoletta Bianchi, Giordana Feriotto, Roberto Gambari, Carlo Mischiati