Abstract: The present invention provides a method for combining a fluid delivery system with an analysis system for performing immunological, chemical, or biological assays. The method provides a miniature plastic fluidic cartridge containing a reaction chamber with a plurality of immobilized species, a capillary channel, and a pump structure along with an external linear actuator corresponding to the pump structure to provide force for the fluid delivery. The plastic fluidic cartridge can be configured in a variety of ways to affect the performance and complexity of the assay performed.
Type:
Grant
Filed:
May 14, 2003
Date of Patent:
July 10, 2007
Assignee:
AST Management Inc.
Inventors:
James Russell Webster, Ping Chang, Shaw-Tzuv Wang, Chi-Chen Chen, Rong-I Hong
Abstract: A process of forming a nitrocellulose film on a carrier includes the steps of (i) atomizing a nitrocellulose solution to form a plurality of fine nitrocellulose particles and (ii) evenly spraying the nitrocellulose particles on the carrier to form the nitrocellulose film. The film has a predetermined thickness. The nitrocellulose solution is atomized by an ultrasonic spraying nozzle to control a size of each of the nitrocellulose particles to be sprayed on the carrier. The nebulizer can be air-assisted by inert air to control characteristics of the nitrocellulose spray pattern.
Type:
Grant
Filed:
October 20, 2004
Date of Patent:
June 26, 2007
Assignee:
AST Management, Inc.
Inventors:
Chi-Chen Chen, James Russell Webster, Rong-I Hong, Yuan-Ru Tsai, Chi-Che Chen, Ko-Yuan Tseng, Ping Chang
Abstract: A capillary electrophoresis device as well as a process for fabrication of the device is disclosed. The capillary electrophoresis device comprises a device body structure having a plurality of reservoirs arrayed thereon for loading a sample, and a plurality of rows of grooves transversely defined to be connected with the reservoirs for receiving at least a capillary electrophoresis chip. The capillary electrophoresis chip comprises a straight main separation channel, an injection channel, and a plurality of sample transport channels defined thereon in liquid communication with the reservoirs. After an electrode means is applied, the sample can be transported into the separation channel for detection and analysis.
Type:
Grant
Filed:
August 4, 2004
Date of Patent:
May 1, 2007
Assignee:
AST Management Inc.
Inventors:
James Russell Webster, Yuan-Fong Kuo, Shao-Tsu Wang, Chun-Hsien Lee
Abstract: An apparatus providing a fluidic cartridge including a first and second substrate and an intermediate interlayer is disclosed. The intermediate interlayer is sealedly interfaced between the first and second substrates to form therein a plurality of channels of capillary dimensions. The apparatus further includes an open reservoir, a pump chamber and a reaction chamber. The open reservoir and reaction chamber are each connected to the pump chamber through the channels. The open reservoir and reaction chamber are in fluid communication with each other via the channels. The apparatus further provides a fluid flow controlling structure, formed in the fluidic cartridge, which restricts a flow of a fluid through the reaction chamber to one direction. The apparatus further provides a linear actuator for providing a pumping action in the pump chamber to pump the fluid to recirculate from the reaction chamber to the open reservior via the channels and pump chamber.
Type:
Grant
Filed:
March 11, 2005
Date of Patent:
March 6, 2007
Assignee:
AST Management Inc.
Inventors:
James Russell Webster, Yuan-Fong Kuo, Shaw-Tsu Wang, Lung-Wen Tai