Patents Assigned to ASTEX TECHNOLOGY LTD.
  • Crystal structure of cytochrome P450
    Publication number: 20050032119
    Abstract: The invention provides the crystal structure of the cytochrome P450 3A4 protein molecule. The structure is set out in Tables 1-4. The structure may be used in to model the interaction of compounds such as pharmaceuticals with this protein, and to determine the structure of related cytochrome P450 molecules.
    Type: Application
    Filed: April 28, 2004
    Publication date: February 10, 2005
    Applicant: ASTEX TECHNOLOGY LTD.
    Inventors: Ian Tickle, Clemens Vonrhein, Dijana Vinkovic, Stewart Kirton, Pamela Williams, Harren Jhoti
  • Crystal structure of cytochrome P450
    Publication number: 20040243319
    Abstract: The invention provides the crystal structure of the cytochrome P450 3A4 protein molecule. The structure is set out in Table 5. The structure may be used in to model the interaction of compounds such as pharmaceuticals with this protein, and to determine the structure of related cytochrome P450 molecules.
    Type: Application
    Filed: October 23, 2003
    Publication date: December 2, 2004
    Applicant: ASTEX TECHNOLOGY LTD.
    Inventors: Ian J. Tickle, Clemens Vonrhein, Pamela A. Williams, Stewart B. Kirton, Harren Jhoti
  • Crystals of cytochrome P450 2C9, structures thereof and their use
    Publication number: 20040053383
    Abstract: The present invention provides cytochrome 2C9 proteins which have been modified to introduce a proline residue at positions 220 or 222 of the wild type sequence which can be crystallised to provide high resolution structures. The structures may be used for homology modelling of other cytochrome P450 structures such as 2C8, 2C18 and 2C19, and for analysis of the interaction of ligands with P450.
    Type: Application
    Filed: April 30, 2003
    Publication date: March 18, 2004
    Applicant: ASTEX TECHNOLOGY LTD.
    Inventors: Pamela Ann Williams, Jose Marie Cosme, Dijana Matak-Vinkovic, Mark Gareth Williams, Harren Jhoti