Patents Assigned to Astra AB
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Patent number: 6861443Abstract: The present invention relates to pharmaceutical compositions comprising a positive modulator of a nicotinic receptor agonist, said positive modulator having the capability to increase the efficacy of the said nicotinic receptor agonist.Type: GrantFiled: March 20, 2001Date of Patent: March 1, 2005Assignee: Astra ABInventors: David Gurley, Thomas Lanthorn
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Publication number: 20040139967Abstract: An actuator for an inhaler for delivering medicament by inhalation, comprising: a main body (2) comprising a tubular member (8) for receiving a canister (7) containing medicament and having a valve stem (11) extending therefrom; and an outlet assembly (4), as a part formed separately of the main body (2), comprising a mouthpiece for guiding medicament to the mouth of a user and a nozzle block (20) for receiving the valve stem (11) of the canister (7) and delivering medicament from the canister (7) into the mouthpiece; wherein at least a part of at least one of the main body (2) and the outlet assembly (4) is configured so as to deform or break on separating the outlet assembly (4) from the main body (2) so as to prevent re-use of the actuator; characterized in that the main body (2) and the outlet assembly (4) are composed of materials having different constitution.Type: ApplicationFiled: November 3, 2003Publication date: July 22, 2004Applicant: Astra ABInventors: Darren Hodson, Jorgen Rasmussen
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Publication number: 20020156101Abstract: The present invention is directed to the intramuscular use of ropivacaine for the manufacture of a medicament for use in the treatment of muskuloskeletal pain, in particular myofascial pain and tendinitis.Type: ApplicationFiled: April 24, 2002Publication date: October 24, 2002Applicant: Astra ABInventors: Goran Isacsson, Dag Selander
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Patent number: 6395291Abstract: The present invention is directed to the intramuscular use of ropivacaine for the manufacture of a medicament for use in the treatment of muskuloskeletal pain, in particular myofascial pain and tendinitis.Type: GrantFiled: March 2, 1999Date of Patent: May 28, 2002Assignee: Astra ABInventors: Göran Isacsson, Dag Selander
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Publication number: 20020042396Abstract: There is provided amino acid derivatives of formula I, 1Type: ApplicationFiled: November 29, 2001Publication date: April 11, 2002Applicant: Astra ABInventors: David Gustafsson, Jan-Erik Nystrom
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Publication number: 20020026938Abstract: An actuator for an inhaler for delivering medicament by inhalation, comprising: a main body (2) comprising a tubular member (8) for receiving a canister (7) containing medicament and having a valve stem (11) extending therefrom; and an outlet assembly (4), as a part formed separately of the main body (2), comprising a mouthpiece for guiding medicament to the mouth of a user and a nozzle block (20) for receiving the valve stem (11) of the canister (7) and delivering medicament from the canister (7) into the mouthpiece; wherein at least a part of at least one of the main body (2) and the outlet assembly (4) is configured so as to deform or break on separating the outlet assembly (4) from the main body (2) so as to prevent re-use of the actuator; characterized in that the main body (2) and the outlet assembly (4) are composed of materials having different constitution.Type: ApplicationFiled: November 13, 2001Publication date: March 7, 2002Applicant: Astra AB.Inventors: Darren Hodson, Jorgen Rasmussen
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Patent number: 6313263Abstract: The present invention provides purified polypeptides which comprise at least a portion of a &dgr; T cell receptor polypeptide, a &ggr; T cell receptor polypeptide, a &ggr;, &dgr; T cell receptor complex or a &ggr;, &ggr; T cell receptor complex. Substances capable of forming complexes with these polypeptides are also provided. Additionally, methods for detecting T cells which have within them or on their surfaces a polypeptide of the present invention are provided. Moreover, methods for diagnosing immune system abnormalities are provided which comprise measuring in a sample from a subject the number of T cells which have within them or on their surfaces a polypeptide of the present invention.Type: GrantFiled: February 10, 1997Date of Patent: November 6, 2001Assignees: Astra AB, President and Fellows of Harvard College, Dana-Farber Cancer InstituteInventors: Michael B. Brenner, Jack L. Strominger, Johnathan Seidman, Stephen H. Ip, Michael S. Krangel
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Patent number: 6277870Abstract: The present invention relates to pharmaceutical compositions comprising a positive modulator of a nicotinic receptor agonist, said positive modulator having the capability to increase the efficacy of the said nicotinic receptor agonist.Type: GrantFiled: May 4, 1998Date of Patent: August 21, 2001Assignee: Astra ABInventors: David Gurley, Thomas Lanthorn
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Patent number: 6235792Abstract: The present invention relates to a novel monophosphate salt of isopropyl-methyl-[2-(3-n-propoxyphenoxy)ethyl]amine. Moreover, the present invention also relates to a process for the preparation of the monophosphate salt of isopropyl-methyl-[2-(3-n-propoxyphenoxy)ethyl]amine as well as a pharmaceutical formulation containing it and its use in medicine.Type: GrantFiled: March 8, 1999Date of Patent: May 22, 2001Assignee: Astra ABInventors: Karol Horvath, Ulf Larsson, Rune Sandberg
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Patent number: 6171799Abstract: The present invention relates to monoclonal antibodies which recognize defined regions of the T-cell receptor (TCR). In a specific embodiment, the invention provides monoclonal antibodies which are reactive with a constant region of the alpha chain of the TCR. In particular embodiments, the invention relates to two monoclonal antibodies, termed &agr;F1 and &agr;F2, which react with two different epitopes on the framework region of the &agr; monomer of the TCR molecule. In another specific embodiment, the invention is directed to monoclonal antibodies reactive with a variable region of the beta chain of the TCR. In particular, the invention provides two monoclonal antibodies, termed W112 and 2D1, which react with &bgr; chain variable regions V&bgr;5.3 and V&bgr;8.1, respectively. In another specific embodiment, the invention is directed to monoclonal antibodies reactive with a variable region of the delta chain of the TCR. In particular, the invention provides monoclonal antibody &dgr;TCS1, isotype IgG2a.Type: GrantFiled: May 25, 1995Date of Patent: January 9, 2001Assignee: Astra ABInventors: Robert V. Skibbens, Larry D. Henry, Charles W. Rittershaus, Wei-Tao Tian, Stephen H. Ip, Patrick C. Kung, Mary Ellen Snider, Jone-Long Ko, Nancy L. Wood
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Patent number: 6150335Abstract: Use of a compound of the formula I ##STR1## for the manufacture of a medicament for the treatment of pain. The compounds are .delta. opioid agonists and thus useful in the treatment of pain without the requirement of co-application of a .mu. opioid agonist.Type: GrantFiled: April 1, 1998Date of Patent: November 21, 2000Assignee: Astra ABInventor: Peter Schiller
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Patent number: 6136817Abstract: New morphinane derivatives of the formula ##STR1## their pharmaceutically acceptable salts, a process for their preparation and their use in the manufacture of pharmaceutical preparations.Type: GrantFiled: August 22, 1995Date of Patent: October 24, 2000Assignee: Astra ABInventor: Helmut Schmidhammer
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Patent number: 6136591Abstract: Process for obtaining an enantiomerically enriched N-acylazetidine-2-carboxylic acid, wherein a racemic N-acylazetidine-2-carboxylic acid ester is contacted with an enzyme that displays enantiospecificity to form enantiomerically enriched N-acylazetidine-2-carboxylic acid.Type: GrantFiled: December 15, 1998Date of Patent: October 24, 2000Assignee: Astra ABInventors: Stephen John C. Taylor, Julian Simon Parratt
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Patent number: 6054594Abstract: Process for obtaining an enantiomerically enriched N-acylazetine-2-carboxylic acid by selectine crystallization of a diastereoisomeric salt formed by relcting an enantiomer of the N-acylazetidine-2-carboxylic acid and an enantiomer of 1-phenylethylamine.Type: GrantFiled: December 16, 1998Date of Patent: April 25, 2000Assignee: Astra ABInventors: Gerard Andrew Potter, Michael C. J. Harris
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Patent number: 6048526Abstract: The present invention relates to monoclonal antibodies which recognize defined regions of the T-cell receptor (TCR). In a specific embodiment, the invention provides monoclonal antibodies which are reactive with a constant region of the alpha chain of the TCR. In particular embodiments, the invention relates to two monoclonal antibodies, termed .alpha.F1 and .alpha.F2, which react with two different epitopes on the framework region of the .alpha. monomer of the TCR molecule. In another specific embodiment, the invention is directed to monoclonal antibodies reactive with a variable region of the beta chain of the TCR. In particular, the invention provides two monoclonal antibodies, termed W112 and 2D1, which react with .beta. chain variable regions V.beta.5.3 and V.beta.8.1, respectively. In another specific embodiment, the invention is directed to monoclonal antibodies reactive with a variable region of the delta chain of the TCR. In particular, the invention provides monoclonal antibody .delta.Type: GrantFiled: June 25, 1993Date of Patent: April 11, 2000Assignee: Astra ABInventors: Robert V. Skibbens, Larry D. Henry, Charles W. Rittershaus, Wei-Tao Tian, Stephen H. Ip, Patrick C. Kung, Mary Ellen Snider, Jone-Long Ko, Nancy L. Wood
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Patent number: 6040314Abstract: There are provided novel compounds of formula I ##STR1## wherein D represents alkyl C1 to 6;T represents a C.sub.3-5 saturated or unsaturated alkylene chain substituted by --(CH.sub.2).sub.m -- NXY; --O--(CH.sub.2).sub.z --NH-- substituted by --(CH.sub.2).sub.m --NXY; or --U--(CH.sub.2).sub.a --N(X)--(CH.sub.2).sub.b --; and a, b, m, X and Y are as defined in the specification together with processes for their preparation, compositions containing them and their use in therapy. Compounds of formula I are expected to be useful inter alia in the treatment of neurodegenerative disorders.Type: GrantFiled: May 7, 1998Date of Patent: March 21, 2000Assignee: Astra ABInventor: James MacDonald
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Patent number: 6034097Abstract: The present invention is directed to compounds that act as analgesics and that have the structure of formula (I): ##STR1## wherein; Z is ##STR2## wherein, n is 1 or 2, and R.sub.0 is C.sub.6-12 aryl or C.sub.7-8 aralkyl; orR.sub.1 is selected from the group consisting of hydrogen; --NH--C.sub.1-6 alkyl; C.sub.1-6 alkyl; C.sub.6-12 aryl; C.sub.7-18 aralkyl; arginyl; and R.sub.30 NHC(.dbd.NH)--, wherein R.sub.30 is hydrogen, C.sub.6-12 aryl, C.sub.7-18 aralkyl, or C.sub.1-6 alkyl;R.sub.2 is hydrogen; C.sub.1-6 alkyl; or OH;R.sub.3 is C.sub.6-12 aryl; C.sub.7-18 aralkyl; --CH.sub.2 --C.sub.6 H.sub.2 R.sub.8 R.sub.9 ;or --CH.sub.2 --OHC.sub.6 HR.sub.8 R.sub.9, wherein each of R.sub.8 and R.sub.9 is independently, or hydrogen;R.sub.4 C.sub.6-12 aryl; C.sub.7-18 aralkyl; C.sub.1-12 alkyl; or a substituted or unsubstituted cyclohexyl;R.sub.5 is C.sub.1-6 alkyl; hydrogen; OH; halogen; SH; NO.sub.2 ; NH.sub.2 ; --NH--C.sub.1-6 alkyl; NH.sub.2 C (.dbd.NH--; NH.sub.2 C (.dbd.NH)--NH--; COOR.sub.31, wherein, R.sub.Type: GrantFiled: October 6, 1997Date of Patent: March 7, 2000Assignee: Astra ABInventors: John DiMaio, Wuyi Wang
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Patent number: 6031007Abstract: The invention is directed to a novel pharmaceutical composition comprising one or more local anaesthetics in oil form, one or more surfactants, water and optionally a taste masking agent. The novel composition is advantageously used as a local anaesthetic for pain relief within the oral cavity.Type: GrantFiled: August 6, 1997Date of Patent: February 29, 2000Assignee: Astra ABInventors: Arne Brodin, Raymond Fynes, Lars Heijl, Adela Nyqvist-Mayer, Marie Scherlund
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Patent number: 6009868Abstract: The present invention relates to a spray mouthpiece arranged on the outer free end of a spray tube. The mouthpiece is adapted by means of intersecting flow passages to atomize liquid which is fed to the spray tube under pressure. The arrangement according to the invention comprises an elongated sleeve which is adapted to be carefully placed on the free end of the spray tube. The sleeve is designed with an end face on which is a centrally located mouthpiece opening. In the sleeve is a cylindrical body connecting to the end face. The body has grooves with which the sleeve forms at least two ducts communicating with the tube. From the tube end, the ducts run approximately axially up to the end face. By means of the intersecting flow passages formed on the end face of the body, the ducts are connected to a chamber that connects to the mouthpiece opening.Type: GrantFiled: October 2, 1996Date of Patent: January 4, 2000Assignee: Astra ABInventor: Billy Nilson
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Patent number: 5998429Abstract: A compound of formula ##STR1## wherein: A is ##STR2## X is O or S; Y is O or S; G and D are independently nitrogen or carbon with the proviso that no more than one of G, D, or E is nitrogen; E is N or C-R.sub.4 ; R.sub.1 is hydrogen or methyl; R.sub.2 is hydrogen or fluoro;R.sub.3 is hydrogen, halogen, C.sub.1 to C.sub.3 alkyl, --OR.sub.5, --CN, --CONH.sub.2, --CO.sub.2 R.sub.5, --NR.sub.5 R.sub.6 or phenyl optionally substituted with one to three of the following substituents: halogen, C.sub.1 to C.sub.3 alkyl, --NO.sub.2, --CN, or --OCH.sub.3 ; R.sub.4 is hydrogen, halogen, C.sub.1 to C.sub.3 alkyl, --OR.sub.5, --CN, --CONH.sub.2, --CO.sub.2 R.sub.5, --NR.sub.5 R.sub.6 or phenyl optionally substituted with one to three of the following substituents: halogen, C.sub.1 to C.sub.3 alkyl, --NO.sub.2, --CN, or --OCH.sub.3 ;or R.sub.2 and R.sub.3 or R.sub.4 may together represent a fused phenyl ring optionally substituted with one or two of the following substituents: halogen, C.sub.1 to C.sub.3 alkyl, --NO.sub.Type: GrantFiled: June 13, 1997Date of Patent: December 7, 1999Assignee: Astra ABInventors: John Macor, Edwin Wu