Abstract: Dental implant component (1; 1′) for a dental prosthesis or a core part of a dental prosthesis to be fabricated on comprising a base section (3; 3′) having a proximal end (2; 2′) for engagement with a support end of a support component and a distal end (7; 7′); and an elongate post section (5; 5′) which projects distally from the distal end of the base section and has a transverse dimension which is substantially less than the transverse dimension of the base section. In a first aspect of the invention the dental implant component is made at least in part from a material which is adapted to burn-out during lost-wax casting whereby a dental prosthesis or core part of a dental prosthesis fabricated on the dental implant component by lost wax casting includes at most only a part of the dental implant component. In a second aspect of the invention the elongate post section is positioned offset on the distal end of the base section.

Abstract: A counting device, comprising: an input 105, 107 for receiving an input signal having at least three distinct input states; memory means 810 for storing a count; and means 620 responsive to a predetermined sequence of input states of said input signal to vary said count, wherein said predetermined sequence includes the at least three input states.

Abstract: A method of treating a patient having a toothless site (10) in a jaw comprising the steps of providing a fixture (1) for anchorage in the bone (5) of the jaw at the toothless site having a coronal end (9); anchoring the fixture in the bone such that the coronal end is submerged beneath the coronal margin (8) of the gingival layer (7) at the toothless site; providing an abutment (31a; 31b; 31c) which is securable in an operational position to the fixture through an opening (12) provided through the gingival layer to the fixture, the abutment having a transgingival structure (37) which comprises an apical section (41) which tapers outwardly from an apical end of the transgingival structure which in the operational position of the abutment is co-planar with the coronal end of the fixture to a position at which the transgingival structure has a maximum transverse dimension and a coronal section (43) contiguous with the apical section which tapers inwardly from the maximum transverse dimension to a coronal end of

Abstract: An actuator for an inhaler for administering medicament by inhalation, comprising: a main body (1) defining a chamber (4) for receiving a canister (3) containing medicament, and including an outlet (11) through which medicament is in use delivered, the canister (3) being in use acted upon by the user in the delivery of medicament; a cover member (2) rotatable in relation to the main body (1) between a first, closed position in which the outlet (11) is covered and a second, open position in which the outlet (11) is exposed, the cover member (2) including a grip portion (33) which in use is acted upon by the user in the delivery of medicament and includes a surface (33a) having a component facing in the sense of rotation of the cover member (2) from the open to the closed position; characterized in that the main body (1) includes a projecting member (16) which includes a surface (16a) having a component facing in the sense of rotation of the cover member (2) from the closed to the open position behind which the

Abstract: The present invention provides optionally substituted and/or annulated compounds of formula (I) wherein X, Y, Z and A is each independently carbon or nitrogen, and at least two of X, Y, Z and A are carbon; and pharmaceutically acceptable salts thereof with the proviso that: 3-(1H-Indol-3-yl)-1H-quinoxalin-2-one, 3-(2-Methyl-1H-indol-3-yl)-1H-quinoxalin-2-one, and 3-(1,2-Diphenyl-1H-indol-3-yl)-1H-quinoxalin-2-one are excluded from compounds of formula (I). The invention includes the use of compounds of formula (I) in medical therapy, particularly in the therapy of conditions requiring inhibition of protein kinase C.

Abstract: The invention provides a pharmaceutical composition for rectal or vaginal administration which comprises at least two parts wherein the composition comprises (i) two or more physiologically acceptable substances each in separate parts of the composition which are such that on admixture they react to produce a physiologically acceptable gas; (ii) in at least one part of the composition a polymer stabiliser which is adapted to facilitate the formation of a water-soluble collapsible foam structure; and (iii) in at least one part of the composition a pharmaceutically active substance; an its use in the treatment or prophylaxis of disorders of the intestines, rectum or vagina.

Abstract: A set of dental implant components for use in fabricating a dental prosthesis (25) comprising a support component (19) for inclusion in a model of a jaw having a support end (17) and a socket (21); a sleeve cylinder (15) on which the dental prosthesis or a core part of the dental prosthesis is to be fabricated, the sleeve cylinder having a distal end adapted to engage with the support end of the support component, a proximal end and a channel extending from a distal opening in the distal end to a proximal opening in the proximal end; and an access passage-forming post (1) having a distal section (9) which presents a distal end (11) of the post and a proximal section (7) which presents a proximal end (3) of the post, the post being adapted to be disposed in an operational position when the distal end of the sleeve cylinder engages with the support end of the support component in which the distal section (9) of the post is releasably secured in the socket in the support component through the proximal opening of

Abstract: Use of cartilage oligomeric matrix protein (COMP) or fragments or analoges thereof for the manufacture of a pharmaceutical composition for prevention or treatment of arthritic conditions is described, wherein the pharmaceutical composition is administrated in an amount effective to prevent or treat the arthritic condition.

Abstract: Novel homodimers that include cysteine-containing peptides having 4-15 amino acid residues can be administered to modulate the immune response in an animal.

Abstract: Peptides being absorbable by the epithelial cell lining in a mammal resulting in a modulated immune response and thereby a therapeutic effect against disease, formulations containing such peptides and uses thereof.

Abstract: There is provided EtO2C—CH2—(R)Cgl—Aze—Pab—OH, or a pharmaceutically-acceptable salt thereof, in a form which is substantially crystalline. It has been found that crystalline forms of EtO2C—CH2—(R)Cgl—Aze—Pab—OH have a high chemical and solid state stability when compared to amorphous forms of the compound.

Abstract: There is provided compounds of formula I, wherein R1, R2, R3, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

Abstract: The invention is directed to a reamer for shaping a bone socket such as an acetabular cavity. The reamer comprises a cutting head for removing material from the socket during rotation of the cutting head. The cutting head comprises a number of relatively long main cutting edges, each of which extends in a direction from a base to a top of the reamer, and a number, higher than the number of main cutting edges, of relatively short peripheral cutting edges, which are located at the base and distributed at angulary spaced intervals about a rotational axis. The invention also provides a method for implanting a prosthesis component into a bone socket. During shaping of the bone socket, a top portion of the reamer is completely received in the bone socket to such an extent, that a cylindrical entrance portion is formed in the socket. The invention also provides a kit including a reamer and a prosthesis.

Abstract: A process for producing a pharmaceutical powder for inhalation comprising crystalline particles of an inhalation compound, comprising dissolving an inhalation compound in a solvent; and introducing the solution containing the inhalation compound in droplet form or as a jet stream into an anti-solvent which is miscible with the solvent and which is under agitation.

Abstract: There are provided novel compounds of formula (I) including their 3,4-dihydropyrimidine tautomer form, wherein R1, R2, R3, R4, R5, X and n are as defined in the specification, and optical isomers and racemates thereof and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are antagonists of N-type neuronal calcium channels useful in the treatment of cerebrovascular ischaemia and pain.

Abstract: The present invention relates to a method for cleaning a container (30) and conduits (32, 33, 36) associated with said container by adding a cleaning solvent to the container and circulating said solvent through said conduits back to said container. In accordance with the invention the cleaning solvent additionally is forced intermittently through a filter unit (1) containing an absorbent material, preferably active carbon (3), and then is allowed to flow through said conduits to said container, said container and conduits thus intermittently being flushed with clean solvent. The container may be a reaction vessel for chemical processes.

Abstract: A dry powder composition comprising formoterol and a carrier substance, both of which are in finely divided form, wherein the formulation has a poured bulk density of from 0.28 to 0.38 g/ml is useful in the treatment of respiratory disorders.

Abstract: A process for the manufacture of the racemic compound of the formula (I), its R-enantiomer (formula R-(I)) and its S-enantiomer (formula S-(I)), and pharmaceutically acceptable salts and/or solvates thereof, as well as new intermediates obtained and used in the process.