Abstract: The present invention concerns novel polypeptides having opioid receptor activity, the genetic material permitting their expression, recombinant cells expressing these polypeptides, and their use.
Abstract: The present invention concerns novel polypeptides having opioid receptor activity, the genetic material permitting their expression, recombinant cells expressing these polypeptides, and their use.
Abstract: The present invention concerns novel polypeptides having opioid receptor activity, the genetic material permitting their expression, recombinant cells expressing these polypeptides, and their use.
Abstract: Compounds of general formula (I)
are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.
Type:
Grant
Filed:
March 5, 1998
Date of Patent:
February 13, 2001
Assignee:
Astra Pharma Inc.
Inventors:
Daniel Delorme, Edward Roberts, Zhongyong Wei
Abstract: Compounds of general formula (I) ##STR1## wherein m is 0 or 1, and n is 1 or 2; are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.
Abstract: Compounds of the formula (I) ##STR1## as well as their pharmaceutically acceptable salts, and pharmaceutical compositions comprising the novel compounds. The novel compounds of the formula (I) are useful in the management of pain.
Type:
Grant
Filed:
April 24, 1997
Date of Patent:
October 10, 2000
Assignee:
Astra Pharma Inc.
Inventors:
Edward Roberts, Niklas Plobeck, Claes Wahlestedt
Abstract: A re-usable nozzle for dispensing a flowable product from a resilient container has a removable one-way valve which facilitates cleaning and sterilisation of the nozzle. When the nozzle is used for dispensing a flowable pharmaceutical, the nozzle controls the amount of suck back of pharmaceutical into the nozzle on completion of dispensing. With a stand off of the valve float from the valve seat during dispensing of about one eighth of an inch (1) the suck back is sufficient to draw any drop of contaminated pharmaceutical at the tip of nozzle on completion of dispensing into the nozzle so as to reduce the risk of contamination of the environment and (2) the suck back is sufficiently small to minimize the risk of damage to any tissue with which the nozzle is intimately associated. Furthermore, with the distance from the valve seat to the nozzle tip being at least about three times the stand off, no contaminated pharmaceutical may enter the container so that the container may be re-used.
Type:
Grant
Filed:
August 31, 1993
Date of Patent:
December 12, 1995
Assignee:
Astra Pharma, Inc.
Inventors:
Anthony F. Ritsky, John E. Cameron, Tjalke K. Schuurmans, Russell L. M. Soobrian, Henryk Klakurka, Robert K. Watson, Christopher G. Szumilas