Patents Assigned to AstraZeneca
  • Compounds for the treatment of dementia related diseases
    Patent number: 7205314
    Abstract: The present invention relates to new compounds of formula (I) wherein Y, P, R1, R2, R3, n, m are defined as in claim 1, a process for their preparation and new intermediates used therein, pharmaceutical composition containing said therapeutically active compounds and to the use of said active compounds in therapy, especially in the prevention and/or treatment of dementia related disease, Alzheimer's Disease and conditions associated with glycogen synthase kinase-3
    Type: Grant
    Filed: December 18, 2002
    Date of Patent: April 17, 2007
    Assignee: AstraZeneca AB
    Inventors: Stefan Berg, Ratan Bhat, James Empfield, Sven Hellberg, Michael Klimas, James Woods
  • 4[piperidin-4-yliden-(3-carbamoylpheny)methyl]benzamide derivatives and their use for the treatment of pain spinal injuries or gastrointestinal disorders
    Patent number: 7205317
    Abstract: Compounds of general formula (I) wherein R1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl and triazolyl; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1–C6 alkyl, NO2, CF3, C1–C6 alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on thephenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, inparticular in the management of pain.
    Type: Grant
    Filed: October 2, 2002
    Date of Patent: April 17, 2007
    Assignee: AstraZeneca AB
    Inventors: William Brown, Christopher Walpole, Zhongyong Wei
  • Method for applying a polymer coating to the internal surface of a container
    Patent number: 7205026
    Abstract: Provided is a method for the application of a polymer coating to an internal surface of a container, which method comprises: (a) heating the inside surface of the container to be coated; (b) spraying an aqueous suspension of a fluorine-containing polymer onto the surface to form a coating on the surface; and (c) sintering the coating; wherein the container comprises a base and one or more side walls defining a container opening and is suitable for storing a medicament, and wherein the spraying step is conducted with a first spraying means configured to produce an axial spray pattern that is substantially conical about an axis perpendicular to the container base.
    Type: Grant
    Filed: January 8, 2001
    Date of Patent: April 17, 2007
    Assignee: AstraZeneca AB
    Inventors: Joseph H Groeger, Jeffrey D Nicoll, Joyce M. Wegrzyn
  • Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
    Publication number: 20070082899
    Abstract: Compounds of Formulae (IA), (IB) or pharmaceutically acceptable salts thereof; wherein Het, X1, R1, R2, R3, R3a and R4 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
    Type: Application
    Filed: September 24, 2004
    Publication date: April 12, 2007
    Applicant: AstraZeneca AB
    Inventors: Daniel Page, Ziping Liu, Maxime Tremblay, Christopher Walpole, Hua Yang
  • Pharmaceutical composition comprising a p2x7 receptor antagonist and a nonsteroidal anti-inflammatory drug
    Publication number: 20070082930
    Abstract: The invention provides a pharmaceutical composition, pharmaceutical product or kit comprising a first active ingredient which is a P2X7 receptor antagonist, and a second active ingredient which is a nonsteroidal anti-inflammatory drug, for use in the treatment of inflammatory disorders.
    Type: Application
    Filed: September 15, 2004
    Publication date: April 12, 2007
    Applicant: ASTRAZENECA AB
    Inventors: Nigel Boughton-Smith, Simon Cruwys
  • Modified release pharmaceutical formulation
    Patent number: 7202236
    Abstract: A modified release pharmaceutical composition comprising, as active ingredient, a compound of formula (I), wherein R1 represents C?1-2#191 alkyl substituted by one or more fluoro substituents; R2 represents hydrogen, hydroxy, methoxy or ethoxy; and n represents 0, 1 or 2; or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable diluent or carrier, provided that the formulation may only contain iota-carrageenan and a neutral gelling polymer when the compound of formula (I) is in the form of a salt; such formulations being of use for the treatment of a cardiovascular disorder
    Type: Grant
    Filed: May 27, 2003
    Date of Patent: April 10, 2007
    Assignee: AstraZeneca AB
    Inventors: Anders Magnusson, Mikael Thune
  • Chemical compounds
    Patent number: 7199143
    Abstract: Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein —N-HET is, for example, (Ic) or (If) wherein R1 is, for example, halogen or a (1–4C)alkyl group which is substituted by one substituent selected from, for example, hydroxy, (1–4C)alkoxy, amino, cyano or azido; Q is selected from, for example, Q1 wherein R2 and R3 are independently hydrogen or fluoro; T is selected from a range of groups, for example, wherein m is 0, 1 or 2; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described.
    Type: Grant
    Filed: February 25, 2003
    Date of Patent: April 3, 2007
    Assignee: AstraZeneca AB
    Inventors: Michael Barry Gravestock, Neil James Hales, Folkert Reck, Fei Zhou, Paul Robert Fleming, Daniel Robert Carcanague
  • Vinyl phenyl derivatives as GLK activators
    Patent number: 7199140
    Abstract: The invention relates to novel compounds of Formula (I) or a salt, solvate or prodrug thereof, wherein A, R1, R2, R3, n and m are described in the specification, useful in the treatment of a disease or condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to methods for preparing compounds of Formula (I) and their use as medicaments in the treatment of diseases mediated by glucokinase.
    Type: Grant
    Filed: June 24, 2002
    Date of Patent: April 3, 2007
    Assignee: AstraZeneca AB
    Inventors: Barry Raymond Hayter, Gordon Stuart Currie, Rodney Brian Hargreaves, Peter William Rodney Caulkett, Roger James
  • Benzimidazole derivatives compositions containing them, preparation thereof and uses thereof
    Publication number: 20070072853
    Abstract: Compounds of Formula (I) or pharmaceutically acceptable salts thereof; wherein R1, R2, R3, R4, n and Ar are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
    Type: Application
    Filed: September 24, 2004
    Publication date: March 29, 2007
    Applicant: ASTRAZENECA AB
    Inventors: Ziping Liu, Claire Milburn, Daniel Page, Maxime Tremblay, Christopher Walpole, Hua Yang
  • Spirofuropyridine aryl derivatives
    Publication number: 20070072887
    Abstract: Compounds of formula I: wherein Ar is a moiety of formula II or III: and pharmaceutically-acceptable salts thereof, wherein A, B, and R1 are as defined in the specification, enantiomers, in vivo-hydrolysable precursors, pharmaceutical compositions and formulations containing them, methods of using them to treat diseases and conditions either alone or in combination with other therapeutically-active compounds or substances, processes and intermediates used to prepare them and uses of them for diagnostic and analytic purposes.
    Type: Application
    Filed: October 21, 2004
    Publication date: March 29, 2007
    Applicant: ASTRAZENECA AB
    Inventor: Eifion Phillips
  • Substituted amines of spirofuropyridines useful in therapy
    Patent number: 7196096
    Abstract: Methods for the treatment of psychotic or intellectual impairment disorders with compounds of formula I, wherein A, R and R1 are as defined in the specification.
    Type: Grant
    Filed: July 14, 2005
    Date of Patent: March 27, 2007
    Assignee: AstraZeneca AB
    Inventors: James T Loch, III, George B Mullen, Eifion D Phillips
  • Novel imidazopyridine compound ii with therapeutic effect
    Publication number: 20070066642
    Abstract: The present invention relates to imidazo pyridine derivatives of the Formula I which inhibit exogenously or endogenously stimulated gastric acid secretion and thus can be used in the prevention and treatment of gastric acid related diseases or gastrointestinal inflammatory diseases.
    Type: Application
    Filed: June 23, 2004
    Publication date: March 22, 2007
    Applicant: ASTRAZENECA AB
    Inventor: Peter Nordberg
  • Benzothiazepine derivatives
    Patent number: 7192945
    Abstract: The present invention relates to compounds of the formula (I): (wherein variable groups are as defined within) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia.
    Type: Grant
    Filed: December 17, 2001
    Date of Patent: March 20, 2007
    Assignee: AstraZeneca AB
    Inventors: Ingemar Starke, Mikael Dahlstrom, David Blomberg
  • Peptides derivatives comprising thiazepine group for the treatment of hyperlipidemic conditions
    Patent number: 7192947
    Abstract: The present invention relates to compounds of formula (I): (wherein variable groups are as defined within) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia.
    Type: Grant
    Filed: June 10, 2003
    Date of Patent: March 20, 2007
    Assignee: AstraZeneca AB
    Inventors: Ingemar Starke, Mikael Ulf Johan Dahlstrom, Suzanne Alenfalk, Tore Skjaret, Malin Lemurell
  • Piperidine derivatives and their use as modulators of chemokine receptor activity (especially CCR5)
    Patent number: 7192973
    Abstract: Compounds of formula (I): wherein L is CH or N; M is CH or N; provided that L and M are not both CH; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal)
    Type: Grant
    Filed: November 12, 2002
    Date of Patent: March 20, 2007
    Assignee: AstraZeneca AB
    Inventor: Howard Tucker
  • Hydroxymethyl substituted dihydroisoxazole derivatives useful as antibiotic agents
    Patent number: 7192974
    Abstract: Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, (I) R1a is NH(C?W)R5 or (a); W is O or S; R2 and R3 are for example H or F; R1 is for example hydrogen, or halogen; R5 is selected from hydrogen, (2–6C)alkyl (optionally substituted); R6 and R7 are independently selected from hydrogen, and (1–4C)alkyl (optionally substituted); wherein R4 is either a hydroxymethyl substituent on C-4? of the isoxazoline ring; or R4 is a hydroxymethyl substituent on C-5? of the isoxazoline ring and the stereochemistry at C-5? of the isoxazoline ring and at C-5 of the oxazolidinone ring is selected, such that the compound of formula (I) is a single diastereomer; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described
    Type: Grant
    Filed: February 24, 2004
    Date of Patent: March 20, 2007
    Assignee: AstraZeneca AB
    Inventors: Michael Barry Gravestock, Daniel Robert Carcanague, Neil James Hales
  • Benzothiazepine derivatives
    Patent number: 7192946
    Abstract: The present invention relates to compounds of formula (I), wherein variable groups are as defined within; pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia.
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: March 20, 2007
    Assignee: AstraZeneca AB
    Inventors: Ingemar Starke, Mikael Ulf Johan Dahlstrom, David Blomberg, Suzanne Alenfalk, Peter Nordberg, Andreas Christer Wallberg, Stig Jonas Bostrom
  • Fluorescence assays for nucleic acid polymerase activity
    Publication number: 20070059701
    Abstract: The present invention provides methods of detecting nucleic acid polymerase activity and methods of detecting compounds that modulate nucleic acid polymerase activity.
    Type: Application
    Filed: June 24, 2004
    Publication date: March 15, 2007
    Applicant: ASTRAZENECA AB
    Inventor: Adam Shapiro
  • Benzimidazole derivatives, compositions containing them, preparation therof and uses thereof
    Publication number: 20070060583
    Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, R4 and Z are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
    Type: Application
    Filed: June 9, 2004
    Publication date: March 15, 2007
    Applicant: AstraZeneca AB
    Inventors: Ziping Liu, Daniel Page, Christopher Walpole, Hua Yang
  • N-type calcium channel antagonists for the treatment of pain
    Patent number: 7189714
    Abstract: Compounds useful for the treatment of pain in accord with the following structural diagram, wherein R1, R2 and R3 are any of a number of groups as defined in the specification and pharmaceutical compositions and methods of treatment utilising such compounds.
    Type: Grant
    Filed: October 31, 2001
    Date of Patent: March 13, 2007
    Assignee: Astrazeneca AB
    Inventors: Marc Chapdelaine, Lucius Kemp, John McCauley