Abstract: Compound of formula (I) wherein A is selected from pyridin-2-yl or thiazol-2-yl and R1, R2 and R3 are as described in the specification and their use in the treatment or prevention of a disease or medical conditions mediated through glucokinase.
Abstract: The present invention provides compounds of formula (I) wherein e, R1, R2, R3, R4, R5, R4, R5, R6, R7, R7a, R7b, A, D, m and n are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
Type:
Grant
Filed:
August 3, 2006
Date of Patent:
May 4, 2010
Assignee:
AstraZeneca AB
Inventors:
Roger Bonnert, Alice Flaherty, Garry Pairaudeau, Michael Stocks
Abstract: The invention provides compounds of formula (I): wherein: X is CH2, O, S(O)2 or NR10; Y is a bond, CH2, NR35, CH2NH, CH2NHC(O), CH(OH), CH(NHCOR33), CH(NHSO2R34), CH2O or CH2S; Z is C(O), or when Y is a bond Z can also be S(O)2; R1 is optionally substituted aryl, optionally substituted heterocyclyl or C4-6 cycloalkyl fused to a benzene ring; and R2, R3, R4, R5, R6, R7 and R8, R9, R10, R32, R33, R34 and R35 are as defined herein; are modulators of chemokine (especially CCR3) activity (for use in, for example, treating asthma). The invention also provides a process for making 4-(3,4-dichlorophenoxy)piperidine, which is useful as an intermediate for making certain compounds of the invention.
Type:
Grant
Filed:
February 17, 2003
Date of Patent:
May 4, 2010
Assignee:
AstraZeneca AB
Inventors:
Lilian Alcaraz, Mark Furber, Mark Purdie, Brian Springthorpe
Abstract: The present invention provides a compound of formula (I) wherein W, R1, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
Type:
Application
Filed:
June 18, 2009
Publication date:
April 29, 2010
Applicant:
ASTRAZENECA AB
Inventors:
Roger Victor Bonnert, Stephen Connolly, Anthony Ronald Cook, Richard Evans, Piotr Raubo
Abstract: The present invention relates to new compounds of formula (I), or salts, solvates or solvated salts thereof, process for their preparation and to new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in the treatment of 5-HT6 mediated disorders such as Alzheimer's disease, cognitive disorders, cognitive impairment associated with schizophrenia, obesity and Parkinson's disease.
Type:
Application
Filed:
July 3, 2006
Publication date:
April 29, 2010
Applicant:
AstraZeneca AB
Inventors:
Gunnar Nordvall, Carl Petersson, Fernando Sehgelmeble
Abstract: Chemical processes and intermediates useful in the manufacture of the quinazoline derivative 4-(3?-chloro-4?-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline, in particular processes for the manufacture of 7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one of Formula II and 4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile of Formula III and their use in the manufacture of the quinazoline derivative.
Abstract: A novel adenine compound represented by the formula (1): [wherein R1 is substituted or unsubstituted alkyl, etc., X is oxygen, etc., A1 is 4- to 8-membered substituted or unsubstituted saturated nitrogen-containing heterocycle containing 1 to 2 hetero atom(s) selected from 1 to 2 nitrogen(s), 0 to 1 oxygen and 0 to 1 sulfur, etc., A2 is substituted or unsubstituted 6- to 10-membered aryl, etc., L1 and L2 are independently a straight chain or branched chain alkylene, etc.], or a pharmaceutically acceptable salt thereof, which is useful as a medicament.
Abstract: Compounds of formula (I) (wherein variable groups are as defined within) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as cholesterol absorption inhibitors for the treatment of hyperlipidaemia are described. Processes for their manufacture and pharmaceutical compositions containing them are also described.
Abstract: The present invention relates to isoquinolinone derivatives of formula (I): wherein are as herein defined; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
Type:
Application
Filed:
October 1, 2009
Publication date:
April 22, 2010
Applicant:
AstraZeneca AB
Inventors:
Stephen John BROUGH, Timothy Jon Luker, Bryan Glyn Roberts, Stephen Anthony St-Gallay
Abstract: The present invention relates to novel 2-heteroaryl substituted indole derivatives, precursors thereof, and therapeutic uses of such compounds, having the structural formula (Ia) below: and to their pharmaceutically acceptable salt, compositions and methods of use. Furthermore, the invention relates to novel 2-heteroaryl substituted indole derivatives that are suitable for imaging amyloid deposits in living patients, their compositions, methods of use and processes to make such compounds. More specifically, the present invention relates to a method of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease as well as measuring clinical efficacy of Alzheimer?s disease therapeutic agents.
Type:
Application
Filed:
March 5, 2008
Publication date:
April 22, 2010
Applicant:
ASTRAZENECA AB
Inventors:
Erwan Arzel, Britt-Marie Swahn, David Wensbo
Abstract: Binding members, especially antibody molecules that bind the IL-6:IL-6Ra complex formed by IL-6 and IL-6Ra, and do not bind either IL-6 or IL-6Ra alone. The binding members may have greater specificity for inhibiting pathological effects of IL-6 rather than beneficial effects of IL-6, as compared with binding members that bind IL-6 or IL-6Ra outside the IL-6:IL-6Ra complex.
Type:
Application
Filed:
November 28, 2007
Publication date:
April 22, 2010
Applicants:
AstraZeneca AB, MedImmune Limited
Inventors:
Keith Cyril Bowers, Steven Godfrey Lane, Philip Mallinder, Isabelle Veronique Yolande Ossona De Mendez
Abstract: An oral pharmaceutical formulation comprising iota-carrageenan, one or more neutral gelling polymers and a basic pharmaceutically active ingredient; which formulation inhibits the release of the basic pharmaceutically active ingredient from the formulation at acidic pH; a process for the manufacture of said formulation; and the use of said formulation in medicine.
Type:
Grant
Filed:
June 19, 2002
Date of Patent:
April 20, 2010
Assignee:
AstraZeneca AB
Inventors:
Cynthia Gaik-Lim Khoo, Helena Gustafsson
Abstract: A process for making a compound of formula (I), said process comprising a) reacting a compound of formula (II) with: i) a compound of formula (III) by nucleophilic aromatic substitution of X2 and ii) a compound of formula (IV) for example by nucleophilic aromatic substitution b) where necessary, converting X1 to a carboxylic acid; and c) coupling of the carboxylic acid group to an appropriate heterocyclic amine; wherein all variables are as defined in the description.
Type:
Grant
Filed:
October 11, 2005
Date of Patent:
April 20, 2010
Assignee:
AstraZeneca AB
Inventors:
Philip Cornwall, David Simon Ennis, Melvyn Edward Giles, Jacob Robert James Perkins, Shelly Louise Jenkin, Jeremy Stephen Parker, Bharti Patel
Abstract: The invention provides compounds of formula (I): wherein R1, R2, A, A1 and B are as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy. The compounds are useful as MMP inhibitors.
Type:
Grant
Filed:
December 14, 2005
Date of Patent:
April 20, 2010
Assignee:
AstraZeneca AB
Inventors:
Balint Gabos, Michael Lundkvist, Magnus Munck Af Rosenschold, Igor Shamovsky, Pavol Zlatoidsky
Abstract: The present invention provides compounds of formula (I) wherein Ra, Rb, R1, R2, R3, R4, R5, R6 and R29 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
Type:
Grant
Filed:
December 19, 2007
Date of Patent:
April 20, 2010
Assignee:
AstraZeneca AB
Inventors:
Stephen Connolly, Alexander Humphries, Premji Meghani
Abstract: This invention relates to use of polymorphisms in human OATP-C in statin therapy because they are associated with an effect on statin pharmacokinetics (PK) in humans, especially rosuvastatin pharmacokinetics. The invention also relates to the use of OATP-C polymorphisms in predicting the efficacy and safety of statins, whose uptake in to the liver is mediated by OATP-C, especially rosuvastatin.
Abstract: A novel adenine compound represented by the formula (1): wherein A represents an (un)substituted aromatic carbocycle or (un)substituted aromatic heterocycle; L1 and L2 each independently represents straighted or branched alkylene, etc.; R1 represents halogen, (un)substituted alkyl, (un)substituted alkenyl, (un)substituted alkynyl, (un)substituted cycloalkyl, (un)substituted aryl, or (un)substituted heteroaryl; R2 and R3 each independently represents hydrogen, or (un)substituted alkyl, (un)substituted alkenyl, (un)substituted alkynyl, (un)substituted cycloalkyl, (un)substituted saturated heterocycle, (un)substituted aryl, or (un)substituted heteroaryl, or R2 combines together with L2 or R3 to form (un)substituted 4- to 8-membered nitrogen-containing saturated heterocycle; X is oxygen, sulfur, SO, SO2, NR7, NR7CO wherein R7 is hydrogen or alkyl, or a single bond; provided that X is a single bond when R1 is halogen, or a pharmaceutically acceptable salt thereof.
Abstract: The invention provides [2-(4-chloro-benzyloxy)-ethyl]-[2-((R)-cyclohexyl-hydroxy-phenyl-methyl)-oxazol-5-yl-methyl]-dimethyl-ammonium napadisylate, pharmaceutical compositions containing it, and its use in therapy.
Type:
Application
Filed:
February 6, 2008
Publication date:
April 15, 2010
Applicants:
ARGENTA DISCOVERY LTD., ASTRAZENECA AB
Inventors:
Barbara Giuseppina Avitabile, David O'Sullivan, James Richard Bull