Patents Assigned to Astur Pharma, S.A.
  • Optically active carbonates as precursors of (+)-zopiclone
    Patent number: 6969767
    Abstract: In the present invention new compounds of formula II, in enantiomerically enriched forms, are described for the first time, where R1 is chloroalkyl. The present invention also includes several new enzymatic processes for the resolution of the enantiomers of the aforementioned carbonates of formula II from the corresponding racemic mixture. The transformation of these carbonates into zopiclone enantiomerically enriched, constitutes an additional aspect of the invention.
    Type: Grant
    Filed: April 2, 2003
    Date of Patent: November 29, 2005
    Assignees: Universidad de Oviedo, Astur Pharma, S.A.
    Inventors: Miguel Bayod Jasanada, Victor M. Sanchez Pedregal, Vicente Gotor Santamaria, M. Rosario Brieva Collado, Laura Fernandez Solares, Monica Diaz Sierra, Jose Manuel Guisan Seijas, Jose Miguel Palomo Carmona, Roberto Fernandez-Lafuente
  • Gene cluster for thienamycin biosynthesis, genetic manipulation and utility
    Publication number: 20040038250
    Abstract: Isolation, cloning and sequencing of the cluster of genes involved in the biosynthesis of the carbapenem thienamycin by streptomyces cattleya, and the use of those genes to increase thienamycin production, and/or related antibiotics, in the producing strains, and obtaining new derivatives by means of genetic manipulation which implies gene expression, mutagenesis by gene replacement and combinatorial biosynthesis.
    Type: Application
    Filed: February 26, 2003
    Publication date: February 26, 2004
    Applicants: ASTUR-PHARMA, S.A., UNIVERSIDAD DE OVIEDO
    Inventors: Luz Elena Nunez, Gloria Blanco, Alfredo Brana, Carmen Mendez, Jose Antonio Salas
  • Azithromycin preparation in its noncryst alline and crystalline dihydrate forms
    Patent number: 6451990
    Abstract: The present invention describes new procedures for the preparation of the macrolide azithromycin in its non-crystalline and crystalline dihydrate forms, which are characterized and clearly differentiated by means of the following methods and techniques: 1. IR Spectroscopy. 2. Differential Scan Calorimetry (DSC). 3. X-Ray Diffraction. 4. Hygroscopicity. 5.
    Type: Grant
    Filed: November 22, 2000
    Date of Patent: September 17, 2002
    Assignee: Astur-Pharma, S.A.
    Inventors: Miguel Santos Bayod Jasanada, Isidro Llorente Garcia, Felix Fernandex Mari