Abstract: A replaceable injection liner for a gas chromatograph is disclosed having a laterally extending external flange at its input end against which an injection septum is placed. A closure cap is positioned over and around the external flange and the injection septum to seal the septum against the flange, the septum closing and sealing the input end of the injection liner. The liner has a seal positioned beyond the flange to seal the interior surface of the injector and isolate it from the atmosphere and the injector's internal pressure.