Abstract: Engineered bacteriophage and methods of forming the bacteriophage are described. Multivalent bacteriophage are described that can include multiple different exogenous polypeptides at a surface of the capsid head. Vaccines and methods of forming and using vaccines are described. A vaccine can include an engineered bacteriophage that exhibits an immunogenic exogenous polypeptide at a surface of the bacteriophage. Multivalent bacteriophage and immunogenic bacteriophage are free of nucleic acids encoding the exogenous polypeptide(s).
Type:
Grant
Filed:
March 18, 2021
Date of Patent:
November 28, 2023
Assignee:
Athanor Biosciences, Inc.
Inventors:
Hossein A Ghanbari, Michael S. Lebowitz