Abstract: The invention relates to hydrosoluble hydroxybisphosphonic derivatives of doxorubicin of formula (I) and the pharmaceutically acceptable salts thereof. The invention also relates to the use of said compounds as a drug, especially in the treatment of a bone tumour. The invention further relates to the pharmaceutical compositions comprising such compounds, the methods for the synthesis thereof and synthesis intermediates.
Type:
Grant
Filed:
November 20, 2015
Date of Patent:
March 26, 2019
Assignee:
Atlanthera
Inventors:
Maxim Egorov, Jean-Yves Goujon, Ronan Le Bot, Emmanuelle David
Abstract: The invention relates to hydrosoluble hydroxybisphosphonic derivatives of doxorubicin of formula (I) and the pharmaceutically acceptable salts thereof. The invention also relates to the use of said compounds as a drug, especially in the treatment of a bone tumour. The invention further relates to the pharmaceutical compositions comprising such compounds, the methods for the synthesis thereof and synthesis intermediates.
Type:
Application
Filed:
November 20, 2015
Publication date:
November 9, 2017
Applicant:
Atlanthera
Inventors:
Maxim Egorov, Jean-Yves Goujon, Ronan Le Bot, Emmanuelle David
Abstract: The present invention relates to a bifunctional hydroxy-bisphosphonic acid derivative of formula (I) below: or a pharmaceutically-acceptable salt thereof, a method for producing the same, pharmaceutical compositions containing the same, and the use thereof as a medicament, as well as a compound of formula (II) below: or a pharmaceutically-acceptable salt thereof, and the use thereof for producing a vectorized molecule of therapeutic or diagnostic purpose.
Type:
Grant
Filed:
March 28, 2012
Date of Patent:
November 3, 2015
Assignee:
ATLANTHERA
Inventors:
Maxim Egorov, Jean-Yves Goujon, Ronan Le Bot
Abstract: The present invention relates to a bifunctional hydroxy-bisphosphonic acid derivative of formula (I) below: or a pharmaceutically-acceptable salt thereof, a method for producing the same, pharmaceutical compositions containing the same, and the use thereof as a medicament, as well as a compound of formula (II) below: or a pharmaceutically-acceptable salt thereof, and the use thereof for producing a vectorized molecule of therapeutic or diagnostic purpose.
Type:
Application
Filed:
March 28, 2012
Publication date:
March 27, 2014
Applicant:
ATLANTHERA
Inventors:
Maxim Egorov, Jean-Yves Goujon, Ronan Le Bot