Patents Assigned to Atlantic Pharmaceuticals (Holdings) Limited
  • Therapeutic antisense oligonucleotide compositions for the treatment of inflammatory bowel disease
    Patent number: 9050354
    Abstract: Disclosed herein is a method for the sustained amelioration and/or treatment of ulcerative colitis comprising rectal administration of a compound comprising an antisense oligonucleotide having the sequence 5?-GCCCAAGCTGGCATCCGTCA-3?, ISIS 2302. The method results in a decrease in the indications of ulcerative colitis for an extended period (greater than 90 days) after the conclusion of the administration of the composition. The composition is well tolerated and systemic exposure is minimal.
    Type: Grant
    Filed: August 7, 2012
    Date of Patent: June 9, 2015
    Assignee: Atlantic Pharmaceuticals (Holdings) Limited
    Inventor: Mark K. Wedel