Abstract: The present invention provides for methods of preparing purified immune globulins, immune globulin compositions, and methods of treating allergies and conditions by administering immune globulin compositions. For example, the present invention provides for purified IgG4 that is essentially free of other IgG subtypes that can be used to treat allergies and other conditions.

Abstract: A method of manufacturing hymenoptera-immune globulin is disclosed. In a presently preferred embodiment, the method involves the steps of concentrating a raw immune globulin solution; freezing the concentrated immune globulin solution; thawing the frozen concentrated immune globulin solution; adding sufficient mono or disaccharide to the thawed concentrated immune globulin solution to yield a solution of about 0.25 to about 0.35 osmolar; filtering the thawed concentrated immune globulin solution; and lyophilizing the concentrated immune globulin solution.