Abstract: Some aspects of this disclosure provide methods of producing decellularized and recellularized cardiac tissues engineering methods of treating heart disease, including heart aneurysm and myocardial infarction. Cardiac tissue engineering of compositing and constructing of a recellularized coronary-based right heart flap or cardiac flap scaffold with its cellular components are also disclosed.
Type:
Application
Filed:
July 12, 2022
Publication date:
June 8, 2023
Applicant:
AtRoo, Inc.
Inventors:
Aram AKBARZADEH, David Elmaleh, Abdol-mohammad Kajbafzadeh
Abstract: The subject matter described herein is directed to methods of producing decellularized and recellularized human prostate tissues and methods of treating disorders of a prostate, including BPH and prostate cancer, are disclosed. Prostate tissue engineering and the composition and construction of a prostate extracellular matrix (ECM) or a prostate tissue scaffold and interactions with its cellular components are also disclosed.
Abstract: A computer-controlled system designed for multi organ decellularization uses continuous organ perfusion for fast, efficient and reproducible organ scaffold preparation under sterile conditions, allowing organ storage for ready organ regeneration. A single organ version is designed to be used for a single organ recellularization using cell, stem cell and autologous cell of organ receiver solutions for minimal or no immunogenic response, mimicking endogenous organ preparation for patients needing transplantation.