Patents Assigned to Attenuon, LLC
  • Thiotungstate analogues and uses thereof
    Patent number: 7851505
    Abstract: The current invention provides novel thiotungstate derivatives, methods of making novel thiotungstate derivatives, pharmaceutical compositions of novel thiotungstate derivatives, methods of using novel thiotungstate derivatives to treat diseases associated with aberrant vascularization, copper metabolism disorders and obesity and methods of using pharmaceutical compositions of thiotungstate derivatives to treat diseases associated with aberrant vascularization, copper metabolism disorders, neurodegenerative disorders, obesity or NF-?B dysregulation.
    Type: Grant
    Filed: May 27, 2004
    Date of Patent: December 14, 2010
    Assignee: Attenuon, LLC
    Inventors: Robert J. Ternansky, Patricia L. Gladstone, Amy L. Allan, Melissa L. P. Price, Andrew Mazar
  • Peptides which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, compositions and uses thereof
    Patent number: 7517855
    Abstract: The present invention relates generally to peptides, which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, methods of making peptides, which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, pharmaceutical compositions of these peptides and methods of using these peptides and pharmaceutical compositions of these peptides to treat diseases associated with aberrant vascularization.
    Type: Grant
    Filed: November 25, 2003
    Date of Patent: April 14, 2009
    Assignee: Attenuon, LLC
    Inventors: Robert J. Ternansky, Stephanie A. Hopkins, Won Hyung Yoon, Amy L. Allan, Patricia L. Gladstone, Sean M. O'Hare, Fernando Donate, Andrew Mazar, Graham Parry, Marian Plunkett
  • Thiomolybdate analogues and uses thereof
    Patent number: 7189865
    Abstract: The current invention provides novel thiomolybdate derivatives, methods of making novel thiomolybdate derivatives, pharmaceutical compositions of novel thiomolybdate derivatives, methods of using novel thiomolybdate derivatives to treat diseases associated with aberrant vascularization, copper metabolism disorders, neurodegenerative disorders, obesity or NF-?B dysregulation and methods of using pharmaceutical compositions of thiomolybdate derivatives to treat diseases associated with aberrant vascularization, copper metabolism disorders, neurodegenerative disorders, obesity or NF-?B dysregulation.
    Type: Grant
    Filed: May 28, 2003
    Date of Patent: March 13, 2007
    Assignees: Attenuon, LLC, Regents of the University of Michigan
    Inventors: Robert J. Ternansky, Andrew Mazar, Patricia L. Gladstone, Dimitri Coucouvanis, Amy L. Allan, Sean M. O'Hare, Melissa L. P. Price, Steven Robert Pirie-Shepherd, Fernando Donate
  • Human kininogen D3 domain polypeptide as an anti-angiogenic and anti-tumor agent
    Patent number: 7119069
    Abstract: Human kininogen domain 3 (HK-D3) polypeptides and biologically active variants and derivatives of HK-D3 are anti-angiogenic. These molecules are used to inhibit angiogenesis or treat a disease or condition in which angiogenesis is pathogenic. Because of their anti-angiogenic potential, these molecules compounds are useful in the treatment of cancer by inhibiting or reversing the growth of primary or metastatic tumors.
    Type: Grant
    Filed: March 24, 2006
    Date of Patent: October 10, 2006
    Assignee: Attenuon, LLC
    Inventors: Fernando Doñate, Andrew P. Mazar
  • Human kininogen D3 domain polypeptide as an anti-angiogenic and anti-tumor agent
    Patent number: 7098187
    Abstract: Human kininogen domain 3 (HK-D3) polypeptides and biologically active variants and derivatives of HK-D3 are anti-angiogenic. These molecules are used to inhibit angiogenesis or treat a disease or condition in which angiogenesis is pathogenic. Because of their anti-angiogenic potential, these molecules are useful in the treatment of cancer by inhibiting or reversing the growth of primary or metastatic tumors.
    Type: Grant
    Filed: September 15, 2003
    Date of Patent: August 29, 2006
    Assignee: Attenuon, LLC
    Inventors: Fernando Doñate, Andrew P. Mazar