Abstract: Methods and compositions are provided for treatment of disorders associated with aberrant adrenal cortex cell behavior, including (but not limited to) treatment of adrenocortical carcinoma (ACC), Cushing's syndrome and/or pituitary ACTH excess (Cushing's Disease). Such methods involve administration of an effective amount N-(2,6-bis(1-methylethyl)phenyl)-N?-((1-(4-(dimethylamino)phenyl)cyclopentyl)-methyl)urea hydrochloride to the patient.
Type:
Grant
Filed:
March 13, 2013
Date of Patent:
August 18, 2015
Assignees:
Atterocor, Inc., The Regents of the University of Michigan
Inventors:
Gary Hammer, Tom Kerppola, Raili Kerppola