Abstract: The invention relates to methods of differentiation, isolation, propagation, and storage of small colony variants (SCVs) of E. coli, preferably E. coli 83972 or E. coli HU2117, or modified or variant forms thereof, and methods for using the prepared SCV bacteria to establish probiotic biofilms in treated subjects and/or on treated medical devices.
Type:
Grant
Filed:
March 27, 2015
Date of Patent:
April 28, 2020
Assignee:
Atterx Biotherapeutics, Inc.
Inventors:
Steven R. Watt, Caleb W. Dorsey, Joshua A. Smith
Abstract: The present invention relates to the field of bacteriology. In particular, the invention relates to methods and compositions for treatment and prevention of infection in wounds, and methods for producing and storing bacterial donor organisms for conjugation-based antibacterial agents. The present invention relates to the field of bacteriology and pharmacology. In particular, the invention relates to novel compositions (e.g., antimicrobial agents) and methods of using the same for treating tissue (e.g., lesions of the skin and other soft tissues) comprising the killing or altering (e.g., inhibiting) growth and virulence of populations of microorganisms.
Type:
Grant
Filed:
December 23, 2015
Date of Patent:
February 25, 2020
Assignee:
Atterx Biotherapeutics, Inc.
Inventors:
Caleb William Dorsey, Joshua Aaron Smith, Steven Robert Watt