Abstract: A system which can analyze compounds with high efficiency, such as in a high throughput drug screening system. The high throughput drug screening system which can test the action of a drug candidate upon a group of cells in a monolayer. A microspace corresponding to a microscopic field area, for example on the order of 100-200 microns in diameter, is isolated from the other cells on the monolayer by creating a seal between a drug delivery perfusion unit and the cells to create the microspace for analysis. A drug candidate is then provided into the isolated microspace. The interaction between the drug candidate and the cells in the isolated microspace can then be evaluated. With the high throughput drug screening system the vast majority of cells on a monolayer can be used for drug testing. The high throughput drug system also makes it more readily available to use primary cells in addition to immortal cells as the cell layer.

Abstract: A system which can analyze compounds with high efficiency, such as in a high throughput drug screening system. The high throughput drug screening system which can test the action of a drug candidate upon a group of cells in a monolayer. A microspace corresponding to a microscopic field area, for example on the order of 100-200 microns in diameter, is isolated from the other cells on the monolayer by creating a seal between a drug delivery perfusion unit and the cells to create the microspace for analysis. A drug candidate is then provided into the isolated microspace. The interaction between the drug candidate and the cells in the isolated microspace can then be evaluated. With the high throughput drug screening system the vast majority of cells on a monolayer can be used for drug testing. The high throughput drug system also makes it more readily available to use primary cells in addition to immortal cells as the cell layer.

Abstract: A novel attachment for a microscope to be coupled to an optical coupling tube of a microscope. The attachment for a microscope includes a light source generating a quasi-collimated light output. Elements are provided for reflecting the light output from the light source towards a specimen in the microscope. Further, elements are provided for propagating a reflection of the light output from the light source from the specimen to a viewing point. The elements for achieving the reflecting and the elements for achieving the propagating may each include a spinning Nipkow disk and a dichroic mirror. The quasi-collimated light output from the light source directly impinges on the Nipkow disk, i.e., without being focused on the Nipkow disk and without passing through a lens. A right angle mirror can also be positioned as one of the elements for achieving the reflecting and the propagating.