Patents Assigned to aTyr Pharma, Inc.
  • COMPOSITIONS AND METHODS COMPRISING GLYCYL-TRNA SYNTHETASES HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES
    Publication number: 20140363415
    Abstract: Isolated glycyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
    Type: Application
    Filed: April 25, 2014
    Publication date: December 11, 2014
    Applicant: aTyr Pharma, Inc.
    Inventors: Leslie Ann Greene, Ryan Andrew Adams, Fei Hong, Ji Zhao, Eva Rebecka Stephanie Armour, Kristi Helen Piehl
  • Histidyl-tRNA synthetases for treating autoimmune and inflammatory diseases
    Patent number: 8835387
    Abstract: The present invention relates generally to compositions and methods comprising histidyl-tRNA synthetase polypeptides or other specific blocking agents for the treatment autoimmune diseases and other inflammatory diseases, including those related to Jo-1 antibodies.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: September 16, 2014
    Assignees: aTyr Pharma, Inc., Pangu Biopharma Limited
    Inventors: Kyle P. Chiang, Elisabeth Gardiner, Ching-Fun Lau, Wing-Sze Lo, Jeffrey Greve, Melissa Ashlock, John D. Mendlein
  • PEGYLATED TYROSYL-TRNA SYNTHETASE POLYPEPTIDES
    Publication number: 20140255378
    Abstract: The present invention provides PEGylated tyrosyl-tRNA synthetase (YRS) polypeptides, compositions comprising the same, and methods of using such polypeptides and compositions for treating or diagnosing a variety of conditions. The PEGylated YRS polypeptides of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic properties compared to non-PEGylated YRS polypeptides.
    Type: Application
    Filed: August 8, 2012
    Publication date: September 11, 2014
    Applicant: aTyr Pharma, Inc
    Inventors: Jeffrey D. Watkins, Ying Ji Buechler, Chi-Fang Wu, Minh-Ha Do, Alain P. Vasserot, John D. Mendlein
  • THROMBOPOIETIC ACTIVITY OF TYROSYL-TRNA SYNTHETASE POLYPEPTIDES
    Publication number: 20140255375
    Abstract: Thrombopoietic compositions are provided comprising tyrosyl tRNA synthetase polypeptides, including truncations and/or variants thereof. Also provided are methods of using such compositions in the treatment of conditions that benefit from increased thrombopoiesis, such as thrombocytopenia.
    Type: Application
    Filed: February 13, 2014
    Publication date: September 11, 2014
    Applicant: aTyr Pharma, Inc.
    Inventors: Rajesh Belani, Jeffry Dean Watkins, Wei Zhang, Alain Phillippe Vasserot
  • Antibodies that bind tyrosyl-tRNA synthetases
    Patent number: 8828395
    Abstract: Hematopoietic-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof, as well as compositions comprising related agents such as antibodies and other binding agents. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of hematopoiesis.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: September 9, 2014
    Assignee: aTyr Pharma, Inc.
    Inventors: Jeffry Dean Watkins, Alain P. Vasserot, Rajesh Belani, Leslie Ann Greene, Ryan Andrew Adams
  • Compositions and methods comprising histidyl-TRNA synthetase splice variants having non-canonical biological activities
    Patent number: 8753638
    Abstract: Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: June 17, 2014
    Assignee: aTyr Pharma, Inc.
    Inventors: Jie Zhou, Ching-Fun Lau, Zhiwen Xu, Wing-Sze Lo, Kristi Helen Piehl, Leslie Ann Greene
  • Compositions and methods comprising glycyl-tRNA synthetases having non-canonical biological activities
    Patent number: 8747840
    Abstract: Isolated glycyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
    Type: Grant
    Filed: January 29, 2013
    Date of Patent: June 10, 2014
    Assignee: aTyr Pharma, Inc.
    Inventors: Leslie Ann Greene, Ryan Andrew Adams, Fei Hong, Ji Zhao, Eva Rebecka Stephanie Armour, Kristi Helen Piehl
  • STRUCTURES OF HUMAN HISTIDYL-TRNA SYNTHETASE AND METHODS OF USE
    Publication number: 20140066321
    Abstract: Provided are histidyl-tRNA synthetase variant polypeptides, X-ray crystallographic and NMR spectroscopy structures of HRS polypeptides, and related compositions and methods for therapy and drug discovery.
    Type: Application
    Filed: July 23, 2013
    Publication date: March 6, 2014
    Applicants: aTyr Pharma, Inc.
    Inventors: Zhiwen Xu, Zhiyi Wei, Xiang-Lei Yang, Mingjie Zhang, Paul Schimmel
  • HISTIDYL-TRNA SYNTHETASES FOR TREATING AUTOIMMUNE AND INFLAMMATORY DISEASES
    Publication number: 20130344096
    Abstract: The present invention relates generally to compositions and methods comprising histidyl-tRNA synthetase polypeptides or other specific blocking agents for the treatment autoimmune diseases and other inflammatory diseases, including those related to Jo-1 antibodies.
    Type: Application
    Filed: February 15, 2013
    Publication date: December 26, 2013
    Applicants: PANGU BIOPHARMA LIMITED, ATYR PHARMA, INC.
    Inventors: Kyle P. Chiang, Elisabeth Gardiner, Ching-Fun Lau, Wing-Sze Lo, Jeffrey Greve, Melissa Ashlock, John D. Mendlein
  • INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF SERYL-TRNA SYNTHETASES
    Publication number: 20130315887
    Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
    Type: Application
    Filed: May 2, 2011
    Publication date: November 28, 2013
    Applicants: PANGU BIOPHARMA LIMITED, ATYR PHARMA, INC.
    Inventors: Leslie Ann Greene, Kyle P. Chiang, Fei Hong, Alain Philippe Vasserot, Jeffry D. Watkins, Cheryl L. Quinn, Wing-Sze Lo, John D. Mendlein
  • INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF ALANYL-TRNA SYNTHETASES
    Publication number: 20130287755
    Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
    Type: Application
    Filed: April 28, 2011
    Publication date: October 31, 2013
    Applicants: PANGU BIOPHARMA LIMITED, ATYR PHARMA, INC.
    Inventors: Leslie Ann Greene, Kyle P. Chiang, Fei Hong, Alain Philippe Vasserot, Wing-Sze Lo, Jeffry Dean Watkins, Cheryl L. Quinn, John D. Mendlein
  • COMPOSITIONS AND METHODS COMPRISING HISTIDYL-TRNA SYNTHETASE SPLICE VARIANTS HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES
    Publication number: 20130243766
    Abstract: Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
    Type: Application
    Filed: February 13, 2013
    Publication date: September 19, 2013
    Applicants: ATYR PHARMA, INC.
    Inventors: Jie Zhou, Ching-Fun Lau, Zhiwen Xu, Wing-Sze Lo, Kristi Helen Piehl, Leslie Ann Greene
  • INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF LYSYL-TRNA SYNTHETASES
    Publication number: 20130243745
    Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
    Type: Application
    Filed: June 1, 2011
    Publication date: September 19, 2013
    Applicants: ATYR PHARMA, INC.
    Inventors: Leslie Ann Greene, Kyle P. Chiang, Fei Hong, Alain Philippe Vasserot, Wing-Sze Lo, Jeffry Dean Watkins, Cheryl L. Quinn, John D. Mendlein
  • INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF METHIONYL-TRNA SYNTHETASES
    Publication number: 20130236440
    Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
    Type: Application
    Filed: May 3, 2011
    Publication date: September 12, 2013
    Applicants: PANGU BIOPHARMA LIMITED, ATYR PHARMA, INC.
    Inventors: Leslie Ann Greene, Kyle P. Chiang, Fei Hong, Alain Philippe Vasserot, Jeffry D. Watkins, Cheryl L. Quinn, Wing-Sze Lo, John D. Mendlein
  • COMPOSITIONS AND METHODS COMPRISING GLYCYL-tRNA SYNTHETASES HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES
    Publication number: 20130236455
    Abstract: Isolated glycyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
    Type: Application
    Filed: January 29, 2013
    Publication date: September 12, 2013
    Applicant: ATYR PHARMA, INC.
    Inventors: Leslie Ann Greene, Ryan Andrew Adams, Fei Hong, Ji Zhao, Eva Rebecka Stephanie Armour, Kristi Helen Piehl
  • INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF TYROSYL-tRNA SYNTHETASES
    Publication number: 20130230508
    Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
    Type: Application
    Filed: August 25, 2011
    Publication date: September 5, 2013
    Applicants: PANGU BIOPHARMA LIMITED, ATYR PHARMA, INC.
    Inventors: Leslie Ann Greene, Kyle P. Chiang, Fei Hong, Alain Philippe Vasserot, Wing-Sze Lo, Jeffry D. Watkins, Cheryl L. Quinn, John D. Mendlein
  • INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF GLUTAMINYL-TRNA SYNTHETASES
    Publication number: 20130230505
    Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
    Type: Application
    Filed: May 26, 2011
    Publication date: September 5, 2013
    Applicants: Pangu BioPharma Limited, aTyr Pharma Inc.
    Inventors: Leslie Ann Greene, Kyle P. Chiang, Fei Hong, Alain Philippe Vasserot, Wing-Sze Lo, Jeffry Dean Watkins, Cheryl L. Quinn, John D. Mendlein
  • INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF P38 MULTI-TRNA SYNTHETASE COMPLEX
    Publication number: 20130230507
    Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
    Type: Application
    Filed: May 4, 2011
    Publication date: September 5, 2013
    Applicant: ATYR PHARMA, INC.
    Inventors: Leslie Ann Greene, Kyle P. Chiang, Alain Philippe Vasserot, Jeffry Dean Watkins, Cheryl L. Quinn, John D. Mendlein
  • INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF GLUTAMYL-PROLYL-TRNA SYNTHETASES
    Publication number: 20130224173
    Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
    Type: Application
    Filed: May 4, 2011
    Publication date: August 29, 2013
    Applicants: PANGU BIOPHARMA LIMITED, aTyr Pharma, Inc.
    Inventors: Leslie Ann Greene, Kyle P. Chiang, Fei Hong, Alain Philippe Vasserot, Jeffry D. Watkins, Cheryl L. Quinn, Wing-Sze Lo, John D. Mendlein
  • INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF GLYCYL-TRNA SYNTHETASES
    Publication number: 20130224174
    Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
    Type: Application
    Filed: July 12, 2011
    Publication date: August 29, 2013
    Applicants: PANGU BIOPHARMA LIMITED, ATYR PHARMA, INC.
    Inventors: Leslie Ann Greene, Kyle P. Chiang, Fei Hong, Alain Philippe Vasserot, Wing-Sze Lo, Jeffry Dean Watkins, Cheryl L. Quinn, John D. Mendlein