Patents Assigned to Auburn University
  • Patent number: 11371021
    Abstract: The present invention relates to the production of cell cultures and tissues from undifferentiated pluripotent stem cells using three-dimensional biomimetic materials. The resultant cell cultures or tissues can be used in any of a number of protocols including testing chemicals, compounds, and drugs. Further, the methods and compositions of the present invention further provide viable cell sources and novel cell delivery platforms that allow for replacement of diseased tissue and engraftment of new cardiomyocytes from a readily available in vitro source. The present invention includes novel methods required for the successful production of cell cultures and tissues, systems and components used for the same, and methods of using the resultant cell and tissue compositions.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: June 28, 2022
    Assignee: Auburn University
    Inventors: Elizabeth A. Lipke, Petra Kerscher, Alexander J. Hodge
  • Patent number: 11358094
    Abstract: An air conditioning device includes a body comprising an inlet plenum portion to receive input air including vapor molecules, a spray chamber portion to receive the input air, the received input air being rigorously mixed within the spray chamber, a sprayer portion to charge a liquid droplet and to release the charged liquid droplet into the rigorously mixed air to cause the charged liquid droplet to attract a vapor molecule, such that the vapor molecule attaches to the charged liquid droplet and separates from the input air, a separation chamber portion to cause the liquid droplet with the attached vapor molecule to separate from the rigorously mixed air and to condense and collect as liquid within an outlet plenum, and an air outlet portion to direct output air from the air conditioning device, a first humidity of the output air being less than a second humidity of the input air.
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: June 14, 2022
    Assignee: AUBURN UNIVERSITY
    Inventor: Lorenzo Cremaschi
  • Patent number: 11339360
    Abstract: Culture systems and methods of using same. The systems include a housing defining an inner space. The inner space includes a headspace and at least a portion of a reservoir. A surface for immobilizing cells is moveable between the headspace and the reservoir. The systems can be used for coculturing methanotrophs and phototrophs for processing biogas and wastewater, particularly from anaerobic digesters.
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: May 24, 2022
    Assignee: Auburn University
    Inventors: Qinghua He, Jin Wang, Matthew V. Hilliard
  • Publication number: 20220095628
    Abstract: Disclosed are compositions and methods that include or utilize plant growth promoting rhizobacteria (PGPR) for improving growth and health in plants and animals. The compositions and methods include or utilize a plant growth promoting rhizobacteria (PGPR) that expresses a protein associated with pectin metabolism, and a saccharide comprising pectin or a pectin-related saccharide.
    Type: Application
    Filed: December 16, 2021
    Publication date: March 31, 2022
    Applicant: Auburn University
    Inventors: Mark R. Liles, Joseph Kloepper
  • Patent number: 11283103
    Abstract: A system and method for rapid lithium ion battery charging are provided. The method for rapid charging a lithium ion battery may include generating a reduced order electrochemical model (ROM) of the lithium ion battery in which a state-of-charge (SOC) model, a side reaction model and a degradation model are embedded. The method may further include calculating an SOC, a side reaction rate, and a lithium plating rate from the ROM. The method may further include generating a charging protocol based on the SOC and a required SOC, and applying the charging protocol to the lithium ion battery.
    Type: Grant
    Filed: October 23, 2019
    Date of Patent: March 22, 2022
    Assignees: HYUNDAI MOTOR COMPANY, KIA MOTORS CORPORATION, AUBURN UNIVERSITY
    Inventors: Sungmin Hong, Minseok Song, Song-Yul Choe
  • Patent number: 11206163
    Abstract: The present disclosure includes a time-to-digital converter (TDC) based RF-to-digital (RDC) data converter for time domain signal processing polar receivers. Polar data conversion achieves better SNR tolerance owing to its phase convergence near the origin in a polar coordinate. The proposed RDC consists of a TDC for phase detection and an analog-to-digital converter (ADC) for amplitude conversion. Unlike the conversional data converter, the proposed ADC's sampling position is guided by the detected phase result from the TDC's output. This TDC assisted data-converter architecture reduces the number of bits required for the ADC. In addition, oversampling is no longer needed. With precisely controlled tunable delay cells and gain compensator, this hybrid data convertor is capable to directly convert Quadrature Amplitude Modulation (QAM) waveforms and Amplitude Phase Shift Keying (APSK) waveforms directly from the RF signal without down-conversion.
    Type: Grant
    Filed: March 18, 2021
    Date of Patent: December 21, 2021
    Assignee: Auburn University
    Inventors: Fa Dai, Hechen Wang
  • Patent number: 11166920
    Abstract: The devices, methods, and compositions disclosed herein accomplish robust cell encapsulation in polymer microparticles using a vertically oriented microfluidic device. A hydrophilic polymer precursor solution is flowed into a first inlet channel, which extends inward from an upper surface of the device housing. A hydrophobic fluid is flowed into a second inlet channel, which extends inward from a lower surface of the device housing. The two inlet channels meet at a junction, and an outlet channel extends away from the two inlet channels. When the two inwardly flowing streams meet at the junction, the polymer precursor solution disperses into the hydrophobic fluid. The dispersed precursor droplets are photopolymerized into microparticles as they travel through the outlet channel. The resulting microparticles are highly uniform, and are larger than conventionally formed microparticles. Cells of varying types can be encapsulated with high viability and spatial uniformity.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: November 9, 2021
    Assignee: Auburn University
    Inventors: Elizabeth A. Lipke, Wen Jun Seeto, Yuan Tian
  • Patent number: 11160867
    Abstract: The present disclosure provides veterinary formulations comprising a therapeutically effective amount of an antiprotozoal compound and a polymer. The disclosure also provides methods of treating trichomoniasis in a bovine and methods of treating a Tritrichomonas foetus infection in a bovine utilizing the veterinary formulations.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: November 2, 2021
    Assignee: AUBURN UNIVERSITY
    Inventor: Sue H. Duran
  • Patent number: 11149028
    Abstract: The invention provides methods for treating cancers, such as melanoma and/or metastatic melanoma, using compounds that interact with and/or inhibit cellular proteins lamin A/C, ATP-dependent RNA helicase DDX1 (DDX1), heterogeneous nuclear ribonuclear protein H1/H2 (hnRNP H2), and/or heterogeneous nuclear ribonuclear protein A2/B1 (hnRNP A2/B1). The invention additionally provides a method for identifying compounds active against melanoma cells.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: October 19, 2021
    Assignees: Nova Southeastern University, Auburn University, Florida Atantic University Board Of Trustees, Torrey Pines Institute for Molecular Studies
    Inventors: Dmitriy Minond, Gregg B. Fields, Marcello Giulianotti
  • Publication number: 20210318379
    Abstract: The methods and systems are directed to automated computer analysis and machine learning. Specifically, the systems and methods for using machine learning to generate fault prediction models and applying the fault prediction models to logical circuits to optimize test point insertion determinations and optimize fault detection in the logical circuit. Disclosed are methods and systems that that generates training data from training circuits (and optionally generate training circuits), trains a learning segment (which may include an artificial neural network (ANN)) using the training data. The learning segment (once trained) generates fault prediction models to predict the quality of a TP inserted on a given circuit location and optimize TPI for a given circuit. The methods and systems described provide computational (CPU/processing) time advantages and precision over conventional methods.
    Type: Application
    Filed: April 9, 2021
    Publication date: October 14, 2021
    Applicant: Auburn University
    Inventors: Spencer Millican, Yang Sun, Soham Roy, Vishwani D. Agrawal
  • Patent number: 11140883
    Abstract: Disclosed are fish with impaired reproductive capacity and methods and compositions for producing the same. The reproductively impaired fish may include catfish, such as Ictalurus punctatus. The disclosed methods may be generally useful for mitigating environmental impact of escaped genetically engineered fish.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: October 12, 2021
    Assignee: AUBURN UNIVERSITY
    Inventors: Rex A. Dunham, Zhenkui Qin, Guyu Qin
  • Patent number: 11142751
    Abstract: A system for modifying the genome of Clostridium strains is provided based on a modified endogenous CRISPR array. The application also describes Clostridium strains modified for enhanced butanol production wherein the modified strains are produced using the novel CRISPR-Cas system.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: October 12, 2021
    Assignee: AUBURN UNIVERSITY
    Inventors: Yi Wang, Jie Zhang
  • Patent number: 11140870
    Abstract: Vapor wake detection is a highly advantageous method and system for detecting explosives and other illicit substances. With vapor wake detection, a canine and a handler are used; however, unlike other detection schemes, the canine leads the handler. After the handler positions the canine in a desired location, the canine detects scents in the air that come to the canine. When the canine detects a trained scent, the canine leads the handler to or follows behind the carrier of the item with the scent. Once the carrier is identified by the handler, the proper personnel are contacted. To implement vapor wake detection effectively, specific rigorous training is utilized.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: October 12, 2021
    Assignee: Auburn University
    Inventors: John C. Pearce, L. Paul Waggoner, Jeanne S. Brock, Timothy Baird, David A. Baffa, Daniel McAfee, Robert E. Leonard
  • Patent number: 11135288
    Abstract: Disclosed are compositions, kits, and methods for enhancing growth in an animal in need thereof. The methods typically comprise administering orally to the animal a composition comprising biodegradable particles, the biodegradable particles comprising a polymer or a co-polymer comprising polymerized lactic acid and having an effective average diameter of 0.5-5 ?m. In the methods, the animal is administered a dose of the biodegradable particles that is effective for improving feed conversion rate in the animal in comparison to an animal that is not administered the composition.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: October 5, 2021
    Assignee: Auburn University
    Inventors: Bernhard Kaltenboeck, Ram B. Gupta, Erfan U. Chowdhury, Courtney A. Ober
  • Publication number: 20210251188
    Abstract: Provided herein are methods of making a training aid for detecting a biohazard, and related devices and methods of using the device, including a canine training aid. The devices are made by positioning a polymer layer in proximity and physically separated from a biological material, so that volatile organic compounds contact and bind or infuse the polymer layer. The device is made render-safe by inactivating the infused polymer layer, such as by heating to a temperature sufficient to inactivate biological agents on or in the analyte-infused polymer layer. The device can be stored in a substantially air-tight configuration for subsequent use in training, such as canine and/or or artificial detectors.
    Type: Application
    Filed: October 27, 2020
    Publication date: August 19, 2021
    Applicants: The United States of America as Represented by The Federal Bureau of Investigation, Department of Ju, Auburn University
    Inventors: Kathleen GILES, Thomas Craig ANGLE, Lowell Paul WAGGONER, Thomas PASSLER, Terrence FISCHER
  • Publication number: 20210250213
    Abstract: The present disclosure includes a time-to-digital converter (TDC) based RF-to-digital (RDC) data converter for time domain signal processing polar receivers. Polar data conversion achieves better SNR tolerance owing to its phase convergence near the origin in a polar coordinate. The proposed RDC consists of a TDC for phase detection and an analog-to-digital converter (ADC) for amplitude conversion. Unlike the conversional data converter, the proposed ADC's sampling position is guided by the detected phase result from the TDC's output. This TDC assisted data-converter architecture reduces the number of bits required for the ADC. In addition, oversampling is no longer needed. With precisely controlled tunable delay cells and gain compensator, this hybrid data convertor is capable to directly convert Quadrature Amplitude Modulation (QAM) waveforms and Amplitude Phase Shift Keying (APSK) waveforms directly from the RF signal without down-conversion.
    Type: Application
    Filed: March 18, 2021
    Publication date: August 12, 2021
    Applicant: Auburn University
    Inventors: Fa Dai, Hechen Wang
  • Patent number: 11069815
    Abstract: A thin-film transistor comprises an annealed layer comprising crystalline zinc oxide. A passivation layer is adjacent to the thin-film transistor. The passivation layer has a thickness and material composition such that when a dose of radiation from a radiation source irradiates the thin-film transistor, a portion of the dose that includes an approximate maximum concentration of the dose is located within the annealed layer. The annealed layer has a thickness and threshold displacement energies after it has been annealed such that: a) a difference between a transfer characteristic value of the thin-film transistor before and after the dose is less than a first threshold; and b) a difference between a transistor output characteristic value of the thin-film before and after the dose is less than a second threshold. The thresholds are based on a desired performance of the thin-film transistor.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: July 20, 2021
    Assignee: Auburn University
    Inventors: Minseo Park, Michael C. Hamilton, Shiqiang Wang, Kosala Yapa Bandara
  • Patent number: 11045553
    Abstract: The present disclosure provides method of making a nanoparticle complex wherein the nanoparticle complex comprises a ligand and a metal cation. The disclosure also provides nanoparticle complexes, methods of treating a disease in a patient utilizing the nanoparticle complexes, methods of identifying a disease in a patient utilizing the nanoparticle complexes, and kits involving the nanoparticle complexes.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: June 29, 2021
    Assignee: AUBURN UNIVERSITY
    Inventors: Feng Li, Wu Chen, Pengyu Chen
  • Patent number: 11013426
    Abstract: Many factors contribute to dogs' superior olfactory capabilities as compared to humans. Studies explored this aspect at the cellular and behavior levels; however, the cognitive-level neural substrates linking them have never been explored. Since sedated dogs cannot sniff, the present application illustrates the cognitive-level linking neural substrate using fMRI of conscious dogs. The head motion of the canine is accounted for by behavioral training and optical motion tracking. The olfactory bulb is commonly activated in both awake and anesthetized dogs, while parietal and frontal structures are activated only in the former and subcortical structures only in the latter. Comparison of low and high odor intensity shows differences in both the strength and spatial extent of activation in higher cognitive structures. Unlike humans, neural structures even at the top of the cognitive hierarchy are modulated by odor concentration in dogs.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: May 25, 2021
    Assignee: Auburn University
    Inventors: Gopikrishna Deshpande, Paul Waggoner, Vitaly Vodyanoy, Hao Jia, Oleg Pustovyy, Thomas Denney, Ed Morrison, Ronald Beyers
  • Publication number: 20210140893
    Abstract: A device for detecting volatile compounds. The device includes a substrate and a matrix disposed on the substrate. The matrix includes a carboxyl-rich binder, a clay, and a pH-sensitive indicator dye admixed with the binder and the clay. The pH-sensitive indicator dye is dimensioned and configured to change color in response to contact with a pre-determined concentration of a volatile compound.
    Type: Application
    Filed: November 11, 2020
    Publication date: May 13, 2021
    Applicants: Auburn University, US Department of Agriculture, Agricultural Research Service
    Inventors: Burak Aksoy, Zhihua Jiang, Mediha Aksoy, Benjamin Beck, Navid E. Alamdari