Abstract: Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR1, N or N-oxide; X is CR2, N or N-oxide; Y is CR3, N or N-oxide; Z is CR4, N or N-oxide; and at least one of W, X, Y, and Z is N or N-oxide; and R9 and R10 are as defined. Also described are methods of using such compounds in the treatment of various conditions, such as cancer.

Abstract: A magnetic flux coupler comprising a magnetically permeable core having a first axis, two coils magnetically associated with the core, each coil defining a pole area located on a first side of the core and the pole areas being separated along the first axis, the coils each having a central region located between the pole areas, an end region opposite to the central region, and a side region between the central region and the end region, wherein an auxiliary pole area is provided beyond the end region of each coil which absorbs leakage flux which would otherwise emanate from the each coil in use in the vicinity of the end region.

Abstract: A tinnitus masking system for use by a person having tinnitus. The system comprises a sound delivery system having left and right ear-level audio delivery devices and is configured to deliver a masking sound to the person via the audio delivery devices such that the masking sound appears to originate from a virtual sound source location that substantially corresponds to the spatial location in 3D auditory space of the source of the tinnitus as perceived by the person. The masking sound being represented by left and right audio signals that are converted to audible sound by the respective audio delivery devices.

Abstract: The invention provides an electric circuit device including a conductive element configured to provide an electrical input to an electrical component, the resistivity of the conductive element being variable based at least on the extent of deformation thereof, and a deformable body coupled directly or indirectly to, or integral with, the conductive element such that deformation of the body causes the conductive element to deform, thereby varying the resistance thereof and altering the input to the electrical component. Said devices may be used singularly or in combination as logic elements within electrical circuits, providing drive and/or control functionality. Particular embodiments provide improved electrostatic generators.

Abstract: A system for quantifying fluorescence elicited on a substance or sample. The system has an excitation light source configured to direct light to an waveguide network. The network has a probe tip adapted to transmit excitation light to the sample and receive fluorescence light elicited from the sample. A detector is configured to receive fluorescence light from the waveguide network and output a signal corresponding to the fluorescence light power, and a control system including a memory component configured to store signal to noise ratio threshold values.

Abstract: A connector is provided for connecting between a first and second structural members. The connector includes a load applying member which bears in use in a first direction against a crushable portion of the first structural member. A retainer retains the load applying member at an initial distance from the second structural member. A non-return mechanism can act in successive cycles of forced movement of the first structural member. When the first structural member is forcibly moved in a direction opposite the first direction the load applying member progressively crushes the crushable portion of the first structural member. When the first structural member is then moved in the first direction the retained location of the load applying member is moved in the first direction relative to the second structural member.

Abstract: An inductive power transfer (IPT) pick-up circuit has a full-wave rectifier (D1-D4) coupled to a resonant circuit (L1 C1) and adapted to rectify an AC current received from the resonant circuit. A pair of inductors (L2 L3) are provided, being arranged to couple the rectifier to an output (VLoad) of the pick-up circuit and alternately store and release energy to the output.

Abstract: The present application relates to the detection of moving vehicles and other objects, in particular though not exclusively for the application of switching stationary charging pads for moving electric vehicle charging. There is provided an electric vehicle detecting apparatus for switching a charging pad for charging a vehicle transmitting a locating signal, the apparatus comprising two sensors separated in the direction of travel of the vehicle, and a detector arranged to detect the vehicle by comparing the locating signals received by each of the two sensors.

Abstract: An inductive power transfer system (IPT) pick-up comprises: a pick-up coil capable of generating a voltage by magnetic induction from a primary conductive pathway, and a tuning capacitor associated with the pick-up coil to provide a first pick-up resonant circuit; a first output associated with a first control means to substantially control the voltage or current provided by the first output; a further resonant circuit connected in series or parallel with the first pick-up resonant circuit; and a second output associated with a second control means to control the voltage or current provided by the second output and a method of providing an additional independently controllable output from an IPT pick-up having a resonant pick-up circuit is also disclosed.

Abstract: The invention relates to a method of making a flame retardant material, and/or to a flame retardant material, and/or a polymer composite including the flame retardant material, and/or a method of making the polymer composite. More particularly, the invention relates to treatment of a keratinous fibre with a reactive amine and an inorganic acid to make a flame retardant material which is can be used in a polymer composite.

Abstract: Magnetic coupling structures for wireless power transfer include overlapping coils which are configured to provide improved flux patterns. Control methods are used to determine the variation in coupling factor relative to alignment between the primary magnetic coupling structures and energise one or more coils of the primary magnetic coupling structure dependent on the relative alignment of the coupling structures to maximise coupling.

Abstract: The invention generally relates to compositions and methods for treating, detecting and assisting in the diagnosis of Streptococcus pyogenes infection, of rheumatic fever or of poststreptococcal glomerulonephritis (PSGN), and compositions and methods for assessing the propensity for developing rheumatic fever or PSGN in subjects in need thereof. Recombinant polypeptides, including recombinant Streptococcus pyogenes SpnA polypeptides, and compositions comprising such polypeptides, for use in such methods are also provided.

Abstract: A magnetic flux pad for receiving or generating magnetic flux. The pad includes two pole areas (11, 12) associated with a magnetically permeable core 14. Coils 17 define the pole areas. The pad allows useable flux to be generated at a significant height above a surface of the pad.

Abstract: An inductive power transfer apparatus may be used for producing or receiving a magnetic field for inductive power transfer. The apparatus has a central coil and two end coils, one of the end coils being provided at each end of the central coil. Some turns of each of the end coils are on one side of the central coil and the remaining turns are on the other side. The end coils act to weaken or cancel flux on one side of the central coil and guide magnetic flux through the central coil to provide an arch shaped flux pattern beyond the apparatus on the other side of the central coil.

Abstract: Several embodiments include a method of computing void fraction in a two-phase mixture in a pipe. A driver and a transmitter antenna can transmit a radio frequency (RF) signal through the pipe. The pipe can convey the two-phase mixture extracted from a geothermal well. The RF signal can pass through the two-phase mixture. A receiver antenna in the pipe can receive the RF signal. A receiver circuit can measure signal strength attenuations of the RF signal at the receiver antenna over a time window. A computation engine can compute an average of the signal strength attenuations over the time window. The computation engine or another computing device can then compute, in real-time, a change in a void fraction of the two-phase mixture based on the average of the signal strength attenuations.

Abstract: An inductive power transfer pickup circuit has a pickup coil (L2) and tuning capacitor (C2) connected in series to provide a series resonant circuit. A bi-directional switch (S1) is used to vary the phase angle between the open circuit pickup coil voltage (VOC) and the pickup coil inductor current (iL) to provide a controlled AC supply to an output of the pickup.

Abstract: A method of determining physiological information for an internal body surface using an open catheter comprising multiple sensors. Sensor potentials are obtained and used to determine catheter potentials within the catheter, and the physiological information for the internal body surface is determined using at least some of the catheter potentials.

Abstract: A multiphase IPT primary track conductor arrangement comprising a first phase conductor and a second phase conductor, the conductors being arranged substantially in a plane and so as to overlap each other and being arranged such that there is substantially balanced mutual coupling between the phase conductors.

Abstract: Embodiments of the invention relate to a method of extracting eye velocity information from a video footage having a plurality of frames, comprising detecting at least part of an eye in at least two frames of the video footage, applying an optical flow algorithm to the at least two frames of the video footage to extract pixel velocity information, and determining a statistical measure from the pixel velocity information within the detected at least part of the eye. Other embodiments of the invention relate to a method of extracting head image trajectory information from a video footage having a plurality of frames, comprising detecting at least part of a facial region of the head image in at least two frames of the video footage, determining a measure of the movement of the at least part of a facial region between the at least two frames, and determining a transformation map from the measure of the movement.

Abstract: An Inductive Power Transfer (IPT) pick-up apparatus includes a magnetically permeable core, a first coil, being wound about the core so as to be inductive coupled therewith such that a current induced in the first coil is most sensitive to a first directional component of magnetic flux and a second coil, being wound about the core so as to be inductively coupled therewith such that a current induced in the second coil is most sensitive to a second directional component of magnetic flux. The first directional component is substantially orthogonal to the second directional component.