Abstract: The present invention provides the following compounds, or pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing said compounds useful as a Notch pathway signaling inhibitor for the treatment of named cancers, sensorineural hearing loss caused by auditory hair cell loss, and inducing auditory hair cell generation.
Type:
Grant
Filed:
July 1, 2016
Date of Patent:
October 22, 2019
Assignees:
Eli Lilly and Company, Audion Therapeutics
Inventors:
Julia Marie Clay, Albert Edge, Philip Arthur Hipskind, John C. Gill, Bharvin Kumar Patel, Helmuth Hendrikus Gerardus Van Es, Aaron D. Wrobleski, Gaiying Zhao