Abstract: This invention relates to methods and compositions for treating diseases of intraocular pressure. More particularly, this invention discloses a range of compounds, devices and methods for detecting and/or affecting intraocular pressure, treating glaucoma diseases, and increasing ocular outflows. Compositions of this disclosure can be used for reducing ocular extracellular complexes.
Type:
Application
Filed:
September 23, 2022
Publication date:
June 8, 2023
Applicant:
AUFBAU MEDICAL INNOVATIONS LIMITED
Inventors:
John T. G. PENA, James Murray MITCHELL, Melissa A. MORGAN, Harmon Lawrence REMMEL
Abstract: Devices, methods and systems are provided for isolating extracellular matrix bodies. More particularly, this invention discloses devices, methods and systems for isolating extracellular matrix bodies from a biological sample for use in diagnosis and prognosis of a subject. A device may have restriction channels for isolating extracellular matrix bodies and uniform flow channels for precise pressure measurements.
Type:
Application
Filed:
September 23, 2022
Publication date:
March 23, 2023
Applicant:
AUFBAU MEDICAL INNOVATIONS LIMITED
Inventors:
John T. G. PENA, James Murray MITCHELL, Luca D'AGOSTINO, Sangeetha Tandalam PALANIVELU, Kunihiro URYU, Harmon Lawrence REMMEL
Abstract: This invention relates to methods and compositions for detecting, identifying and treating glaucoma diseases. In addition, this invention discloses compositions and methods for affecting intraocular pressure and increasing ocular outflows in glaucoma. Compositions are provided for treating a glaucoma disease, reducing intraocular pressure, and/or reducing ocular extracellular vesicle complexes in a subject.
Type:
Application
Filed:
March 16, 2022
Publication date:
July 7, 2022
Applicants:
CORNELL UNIVERSITY, AUFBAU MEDICAL INNOVATIONS LIMITED
Inventors:
John T. G. PENA, James Murray MITCHELL, Harmon Lawrence REMMEL