Abstract: A mixing applicator for mixing a fluid substance with a solid substance to obtain a resulting substance having a desired consistency, comprises: two valves slidably displaceable within a hollow elongated barrel and sequentially arranged along a longitudinal axis, the valves having a third cross-sectional shape being complementary to a first cross sectional shape, thereby providing fluid-tight engagement within the first cross-sectional shape, the third cross-sectional shape being mismatched with a second cross-sectional shape to form a mismatch zone along a length of a chamber, the mismatch zone allowing fluid flow around the valves, thereby to allow the two valves to effect mixing of the fluid substance with the solid substance and subsequently to remove excess fluid to obtain the resulting substance having the desired consistency.

Abstract: Bone graft compositions for repairing bone defects, which are characterized by a chemical composition of cementitious, non-cementitious, highly-resorbable and poorly-resorbable particulate substances, and further characterized by a specific particle size distribution that includes two or more different ranges of particle size, are disclosed. Further disclosed are articles of manufacturing and unit dosage forms containing the bone graft compositions, methods of repairing bone defects utilizing the bone graft compositions, and processes of preparing the same. Also provided are applicators for applying flowable mixtures formed by mixing a dry composition and a liquid carrier, which are particularly useful for preparing and applying bone graft compositions, as well as methods of using same.