Abstract: The invention relates to a method of performing in situ hybridization such as fluorescence in situ hybridization (FISH) using liposomal spherical nucleic acids (L-SNAs) nanoparticles labeled with dye molecules. The nanoparticles contain one or more nucleic acids that recognize a target of interest in a sample.
Type:
Application
Filed:
February 21, 2017
Publication date:
August 24, 2017
Applicant:
AuraSense, LLC
Inventors:
David A. Giljohann, Richard Kang, Pinal Patel
Abstract: Aspects of the invention relate to novel methods and compositions for assessing the level of cellular uptake of a nanoparticle construct, assessing the level of target binding of a nanoparticle construct and assessing the levels of RNAs and proteins in a given cell.