Abstract: The disclosure provides for improved pharmaceutical compositions containing deferasirox (DFX) and methods of manufacturing the same. In particular, the compositions are prepared using thermokinetic compounding and provide improved properties as well as more efficient methods of manufacture.
Type:
Application
Filed:
November 24, 2023
Publication date:
March 21, 2024
Applicant:
AustinPx, LLC
Inventors:
Dave A. MILLER, Justin M. KEEN, Sandra U. KUCERA
Abstract: The disclosure provides for improved pharmaceutical compositions containing deferasirox (DFX) and methods of manufacturing the same. In particular, the compositions are prepared using thermokinetic compounding and provide improved properties as well as more efficient methods of manufacture.
Type:
Grant
Filed:
February 6, 2019
Date of Patent:
January 23, 2024
Assignee:
AustinPx, LLC
Inventors:
Dave A. Miller, Justin M. Keen, Sandra U. Kucera
Abstract: Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.
Type:
Application
Filed:
July 25, 2022
Publication date:
June 8, 2023
Applicants:
BOARD OF REGENTS, THE UNIVERISTY OF TEXAS SYSTEM, AustinPx, LLC
Inventors:
Chris BROUGH, James W. MCGINITY, Dave A. MILLER, James C. DINUNZIO, Robert O. WILLIAMS, III