Abstract: Described is an aqueous liquid oral gliptin composition comprising a gliptin or a pharmaceutically acceptable salt or ester thereof, and an artificial non-sugar alcohol sweetening agent, the solution having a sugar alcohol content of less than 25 w/v %. The composition has an improved taste and stability as compared to known compositions. Also described is a method comprising the steps of heating 80-95 v/v % of the water to 40-65° C., admixing the antioxidant, and, if present, the chelating agent and buffering agent, optionally, cooling down to 25-35° C.
Type:
Grant
Filed:
October 23, 2020
Date of Patent:
April 2, 2024
Assignee:
AUTHENDA PHARMACEUTICALS AG
Inventors:
Ioannis Psarrakis, Konstantinos Lioumis